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  3. Puril 300mg Tablet 10's

Puril 300mg Tablet 10's, Pack of 10 TABLETS
Written By ,
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

ALLOPURINOL-100MCG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Puril 300mg Tablet

Puril 300mg Tablet belongs to a class of medication called 'enzyme inhibitor', primarily used to decrease blood uric acid levels in the body. It is used to treat Gout (increased uric acid leading to inflammation), kidney stones, bladder stones. Gout is a type of inflammatory reaction (allergic reaction) to uric acid crystals that form and accumulate inside joints, especially  big toe, due to high uric acid levels in the blood resulting in immense pain in joints. 

Puril 300mg Tablet contains allopurinol, which works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body. 

Take Puril 300mg Tablet as prescribed by your doctor. You are advised to take Puril 300mg Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. The most common side effects of Puril 300mg Tablet are upset stomach, diarrhoea, skin rash, drowsiness. Most of these side effects of Puril 300mg Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. 

Do not take Puril 300mg Tablet if you are allergic to any of its ingredients. Puril 300mg Tablet contains monohydrated lactose, if you are intolerant to some sugars, call your doctor before taking this drug. If you are pregnant or planning to get pregnant, are breast-feeding ask your doctor for advice before taking this medicine. Drink at least 2-3 litres of water so that you stay hydrated. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately.

Uses of Puril 300mg Tablet

Gout (increased uric acid in joints), Kidney stones, Bladder stones

Directions for Use

Take Puril 300mg Tablet with or without food as directed by your physician. Swallow it as a whole with a glass of water. Do not crush, chew, or break it.

Medicinal Benefits

Puril 300mg Tablet contains an 'enzyme inhibitor', medication, primarily used to decrease blood uric acid levels in the body. In addition to this, it is sometimes also used to treat pain caused by pancreas disease, seizures, and improve survival after bypass surgery. It also prevents the rejection of a kidney transplant. Puril 300mg Tablet contains allopurinol, an enzyme inhibitor primarily used to decrease blood uric acid levels in the body. It works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body.

Storage

Store in a cool and dry place away from sunlight
Side effects of Puril 300mg Tablet
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Limit processed foods and eat more vegetables and fruits.
  • Exercise at least 30 minutes every day.
  • Maintain a healthy weight.
  • Quit smoking as it can worsen kidney damage.
  • Control your blood pressure and blood glucose.
  • Limit salt intake and alcohol consumption.
  • Take cold water baths avoiding soap.
  • Avoid scratching and scrubbing to prevent infections while itching.
  • Use nets to prevent insects and mosquitoes.
  • Stop using lotions and creams that cause irritation.
  • Avoid alcohol and caffeine intake.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Drug Warnings

Do not take Puril 300mg Tablet if you are allergic to any of its ingredients. Puril 300mg Tablet  contains monohydrated lactose; if your doctor mentioned that you are intolerant to some sugars, call your doctor before taking this drug. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine, you have heart problems or high blood pressure and you take diuretics and/or a medicine called ACE-inhibitors, you have thyroid problems. In rare cases, Puril 300mg Tablet can cause bone marrow depression, especially in patients who are already taking that can cause bone marrow depression. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately. Puril 300mg Tablet can cause drowsiness so do not operate machinery or car as it can impair judgment.

Drug-Drug Interactions

verifiedApollotooltip
AllopurinolDidanosine
Critical
AllopurinolCaptopril
Severe

Drug-Drug Interactions

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AllopurinolDidanosine
Critical
How does the drug interact with Puril 300mg Tablet:
When Didanosine is taken with Puril 300mg Tablet, can increase the blood levels of didanosine.

How to manage the interaction:
Taking Puril 300mg Tablet with Didanosine lead to an interaction, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
AllopurinolCaptopril
Severe
How does the drug interact with Puril 300mg Tablet:
Co-administration of Puril 300mg Tablet with Captopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 300mg Tablet and Captopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolMoexipril
Severe
How does the drug interact with Puril 300mg Tablet:
Co-administration of Puril 300mg Tablet with Moexipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 300mg Tablet and Moexipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.
AllopurinolRamipril
Severe
How does the drug interact with Puril 300mg Tablet:
Co-administration of Puril 300mg Tablet with Ramipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 300mg Tablet and Ramipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolDeferiprone
Severe
How does the drug interact with Puril 300mg Tablet:
Co-administration of Puril 300mg Tablet with Deferiprone may increase the risk of dangerous blood clots.

How to manage the interaction:
If you are supposed to take Puril 300mg Tablet and Deferiprone together, your doctor may advise you to take blood thinner or monitor you more frequently to safely use both medications. However, if you experience shortness of breath, chest pain, coughing up blood, difficulty breathing, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, contact your doctor immediately as these may be signs and symptoms of blood clots. Do not discontinue any medications without consulting a doctor.
AllopurinolEnalapril
Severe
How does the drug interact with Puril 300mg Tablet:
Coadministration of Puril 300mg Tablet with Enalapril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 300mg Tablet and Enalapril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not stop using any medications without consulting your doctor.
AllopurinolMercaptopurine
Severe
How does the drug interact with Puril 300mg Tablet:
Co-administration of Puril 300mg Tablet with Mercaptopurine together may increase the effects of mercaptopurine.

How to manage the interaction:
If you take Puril 300mg Tablet and Mercaptopurine together, a doctor may adjust the dose or recommend special tests to use both medications safely. However, contact a doctor immediately if you develop any symptoms such as chills, fever, sore throat, mouth sores, body pains, weakness, muscle pain, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhea. Do not discontinue any medications without a doctor's advice.
AllopurinolPerindopril
Severe
How does the drug interact with Puril 300mg Tablet:
Co-administration of Puril 300mg Tablet with Perindopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 300mg Tablet and Perindopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms, contact your doctor immediately . Do not discontinue any medications without consulting a doctor.
AllopurinolEntecavir
Severe
How does the drug interact with Puril 300mg Tablet:
Coadministration of Puril 300mg Tablet with Entecavir may increase the blood levels of one or both medicines and increase side effects.

How to manage the interaction:
If you are supposed to take Puril 300mg Tablet and Entecavir together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience increased side effects, contact your doctor.
AllopurinolQuinapril
Severe
How does the drug interact with Puril 300mg Tablet:
Co-administration of Puril 300mg Tablet with Quinapril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Puril 300mg Tablet and Quinapril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Purines are found in certain foods such as alcohol, fish, meat, bacon. People with gout should restrict or avoid them greatly.
  • Losing weight helps lower the levels of uric acid.
  • It is also beneficial to drink plenty of fluids. However, the restricted use of alcohol and tobacco is recommended, raising the levels of uric acid.
  • Maintain a diet that is rich in fruits, vegetables, whole grains, and low-fat dairy products.

Habit Forming

No

Therapeutic Class

GOUT THERAPY

Drug-Diseases Interactions

verifiedApollotooltip
ALLOPURINOL-100MCGAbnormality of white blood cells, not elsewhere classified
Moderate
ALLOPURINOL-100MCGVolume depletion
Moderate

Drug-Diseases Interactions

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ALLOPURINOL-100MCGAbnormality of white blood cells, not elsewhere classified
Moderate
How does the disease interact with Puril 300mg Tablet:
Puril 300mg Tablet should be administered cautiously to patients with or predisposed to bone marrow suppression.

How to manage the interaction:
Puril 300mg Tablet should be used with caution in patients with or who are at risk of developing bone marrow suppression.
ALLOPURINOL-100MCGVolume depletion
Moderate
How does the disease interact with Puril 300mg Tablet:
Puril 300mg Tablet should be used with caution in patients with dehydration.

How to manage the interaction:
Puril 300mg Tablet should be used with caution in patients with dehydration. Adequate hydration is necessary during treatment with Puril 300mg Tablet.
ALLOPURINOL-100MCGAlcoholic liver disease
Moderate
How does the disease interact with Puril 300mg Tablet:
Puril 300mg Tablet should be administered cautiously in patients with liver disease.

How to manage the interaction:
Puril 300mg Tablet should be used with caution in patients with liver disease. Regular monitoring of liver function tests is recommended in these patients during the early stages of therapy.
ALLOPURINOL-100MCGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Puril 300mg Tablet:
Puril 300mg Tablet should be used with caution in patients with renal dysfunction.

How to manage the interaction:
Puril 300mg Tablet should be used with caution in kidney failure patients. Kidney function should be monitored during the initial stages of therapy, and the dosage reduced or the drug withdrawn if necessary.

FAQs

Puril 300mg Tablet contains allopurinol, an enzyme inhibitor that works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for uric acid formation. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body. 

If you are taking Puril 300mg Tablet and it makes you vomit, then your contraceptive pill would not be effective, and it could lead to unwanted pregnancy. If you are of childbearing age, inform your doctor before starting Puril 300mg Tablet and use another form of contraceptive like condoms.

Initially, when you start Puril 300mg Tablet , it can increase the number of gout attacks. Please do not stop taking Puril 300mg Tablet on having an acute attack (sudden attack) of gout as it can make the attack even worse. Co-administration with an anti-inflammatory agent (colchicine) is recommended and slowly increasing the dose of Puril 300mg Tablet .

Generally, when Puril 300mg Tablet is given to elderly patients (above 65 years), the dose is lowered depending upon the patient's condition. Also, if mention all underlining disease you suffer from which could affect Puril 300mg Tablet , the dose will be adjusted accordingly by your doctor

Yes, Puril 300mg Tablet can cause drowsiness in some people. It can even make you feel dizzy or have a problem with coordination. It is advisable to avoid driving or operate machinery to avoid any unpleasant side effects.

No, Puril 300mg Tablet is not an anti-inflammatory medicine. It works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body. 

It may take several weeks to lower the uric acid levels, before you start feeling better or notice any significant reduction in attacks of gout.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • CAPTOPRIL
  • AMPICILLIN
  • AMOXICILLIN
  • DICOUMAROL
  • PHENPROCOUMON
  • WARFARIN
  • CHLORPROPAMIDE
  • TOLBUTAMIDE
  • PHENYTOIN
  • CARBAMAZEPINE
  • AZATHIOPRINE
  • MERCAPTOPURINE
  • CYCLOPHOSPHAMIDE
  • CYCLOSPORINE
  • THEOPHYLLINE

Special Advise

  • Drink at least 8 glasses of water or other fluids each day while taking Puril 300mg Tablet unless directed to do otherwise by your doctor. If you are a kidney patient consult a doctor before any fluid intake. 
  • If you are intolerant to sugars, please mention your doctor before starting Puril 300mg Tablet .
  • The doctor will monitor your kidney function constantly before and during you take Puril 300mg Tablet .
  • A liver function test should be done regularly to monitor liver enzymes as Puril 300mg Tablet can cause liver enzyme fluctuations.

Disease/Condition Glossary

Gout: It is a type of inflammatory (allergic reaction) to uric acid crystals that form and accumulate inside feet, knuckles, and surrounding bone joints due to high uric acid levels in the blood, resulting in immense pain in joints. The pain may be severe, but the condition improves with medication. To avoid bone and cartilage damage and weakening of the kidneys, repeated gout attacks can require long-term medication. In areas such as the wrists, elbows, feet, or earlobes, chronic gout sufferers can feel small hard lumps forming over time in the soft flesh. These deposits are concentrations of uric acid crystals, called tophi, and over time can cause pain and stiffness. 

Kidney stones: It is a problem in which hard deposits occur in the kidney leading to stones. A kidney stone comprises mainly four types of calcium oxalate, uric acid, struvite and cystine. It is due to the increased level of uric acid in the body. As a result, uric acid crystals start depositing in the kidney, known as renal calculi/nephrolithiasis/urolithiasis.

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