Can I stop taking R-Cinex 600 Tablet on my own?

Do not stop taking R-Cinex 600 Tablet despite symptomatic relief. To treat your condition effectually, continue taking R-Cinex 600 Tablet for as long as it has been prescribed for you.

Can I take antacids with R-Cinex 600 Tablet?

Do not take R-Cinex 600 Tablet along with antacids as it might decrease the effectiveness of R-Cinex 600 Tablet. Maintain a minimum gap of 1hour between both.

Can I take R-Cinex 600 Tablet with other TB medicines?

Consult your doctor before taking R-Cinex 600 Tablet with other medicines. Medicines used to treat TB such as PAS (P-amino salicylic acid) and cycloserine should be taken 8hours apart from R-Cinex 600 Tablet.

What foods should I avoid while taking R-Cinex 600 Tablet?

R-Cinex 600 Tablet contains isoniazid which might interact with foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking R-Cinex 600 Tablet.

Does R-Cinex 600 Tablet affect contraception?

R-Cinex 600 Tablet might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception such as condoms or the coil while taking R-Cinex 600 Tablet. Consult your doctor if you have any concerns regarding this; your doctor may suggest an alternate method of contraception.

Does R-Cinex 600 Tablet cause discolouration of teeth?

R-Cinex 600 Tablet may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time even after you stop taking R-Cinex 600 Tablet. Do not worry as it is a common side-effect of R-Cinex 600 Tablet.

Does R-Cinex 600 Tablet stain contact lens?

Yes, R-Cinex 600 Tablet might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lens while taking R-Cinex 600 Tablet.

Does R-Cinex 600 Tablet affect diagnostic test results?

R-Cinex 600 Tablet may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking R-Cinex 600 Tablet.

Does R-Cinex 600 Tablet cause liver problems?

Yes, R-Cinex 600 Tablet may cause liver problems, especially in people who are 35 and older. Consult your doctor if you notice symptoms such as yellowing of eyes or skin, dark urine, pale stools, weakness, loss of appetite, nausea or vomiting. Your doctor may advise you to get regular liver tests while taking R-Cinex 600 Tablet to check how your liver is functioning.

R-Cinex 600 Tablet 3's

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

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Whats That

About R-Cinex 600 Tablet

R-Cinex 600 Tablet belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as the kidneys, brain, spine, and bone marrow.

R-Cinex 600 Tablet is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, R-Cinex 600 Tablet kills Mycobacterium tuberculosis which causes TB (tuberculosis).

In some cases, you may experience certain common side-effects such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor before taking R-Cinex 600 Tablet if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking R-Cinex 600 Tablet as it passes into breast milk. R-Cinex 600 Tablet may cause dizziness, and vision problems, so drive only if you are alert. Avoid alcohol consumption while taking R-Cinex 600 Tablet as it could lead to increased drowsiness, dizziness and liver damage.

Uses of R-Cinex 600 Tablet

Tuberculosis.

Directions for Use

Take R-Cinex 600 Tablet 30 minutes before food or 2 hours after food. Swallow R-Cinex 600 Tablet as a whole; do not crush or chew it.

Key Benefits

R-Cinex 600 Tablet is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, R-Cinex 600 Tablet kills Mycobacterium tuberculosis which causes TB (tuberculosis).

Storage

Store in a cool and dry place away from sunlight

Side effects of R-Cinex 600 Tablet

Nerve Damage Causing Weakness, Pain And Numbness In Limbs

If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
Use compression socks and make sure to rest for a while to get relief from pain.
Avoid smoking and intake of alcohol or fluids that aggravate the pain.
Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.

Tingling in the feet and hands

Temporary rise in liver enzymes

Reddening Of The Face

Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:

Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Loose/ Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug Warnings

Do not take R-Cinex 600 Tablet if you are allergic to any of its contents; if you have jaundice, or if you are taking HIV medicines (saquinavir or ritonavir). Before starting R-Cinex 600 Tablet, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Consult your doctor before taking R-Cinex 600 Tablet if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking R-Cinex 600 Tablet as it passes into breast milk. R-Cinex 600 Tablet may cause dizziness, and drowsiness, so drive only if you are alert. Avoid alcohol consumption while taking R-Cinex 600 Tablet as it could lead to increased drowsiness, dizziness and liver damage.

Drug-Drug Interactions

IsoniazidRegorafenib

Critical

IsoniazidLomitapide

Critical

Drug-Drug Interactions

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IsoniazidRegorafenib

Critical

How does the drug interact with R-Cinex 600 Tablet:
When R-Cinex 600 Tablet is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with R-Cinex 600 Tablet is not recommended, it taken can be taken if prescribed by the doctor.

IsoniazidLomitapide

Critical

How does the drug interact with R-Cinex 600 Tablet:
When Lomitapide is taken with R-Cinex 600 Tablet, R-Cinex 600 Tablet may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking R-Cinex 600 Tablet with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.

IsoniazidLovastatin

Critical

How does the drug interact with R-Cinex 600 Tablet:
When Lovastatin is taken with R-Cinex 600 Tablet, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking R-Cinex 600 Tablet with Lovastatin is not recommended but can be taken if a doctor has prescribed it.

RifampicinSaquinavir

Critical

How does the drug interact with R-Cinex 600 Tablet:
Taking saquinavir with R-Cinex 600 Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and R-Cinex 600 Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

RifampicinIndinavir

Critical

How does the drug interact with R-Cinex 600 Tablet:
When Indinavir is taken with R-Cinex 600 Tablet, it can reduce the blood levels and effects of Indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and R-Cinex 600 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

RifampicinPirfenidone

Critical

How does the drug interact with R-Cinex 600 Tablet:
Taking pirfenidone with R-Cinex 600 Tablet can reduce the levels and effects of pirfenidone

How to manage the interaction:
Although there is an interaction between pirfenidone and R-Cinex 600 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

RifampicinDarunavir

Critical

How does the drug interact with R-Cinex 600 Tablet:
Taking darunavir with R-Cinex 600 Tablet can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and R-Cinex 600 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

RifampicinVoriconazole

Critical

How does the drug interact with R-Cinex 600 Tablet:
Taking Voriconazole with R-Cinex 600 Tablet can increase blood level of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole with R-Cinex 600 Tablet, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

RifampicinRanolazine

Critical

How does the drug interact with R-Cinex 600 Tablet:
When ranolazine is taken with R-Cinex 600 Tablet, it can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and R-Cinex 600 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

IsoniazidTeriflunomide

Severe

How does the drug interact with R-Cinex 600 Tablet:
Using R-Cinex 600 Tablet with Teriflunomide can increase the risk and severity of the side effects of the liver.

How to manage the interaction:
Taking R-Cinex 600 Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to consult a doctor: Fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, nausea, vomiting, abdominal pain, dark urine, light colored stool, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
Foods rich in vitamin C such as kiwi, broccoli, and bell pepper helps in improving the immune system.
Avoid processed and fried foods.
Warm ginger tea or warm soup can help in providing relief from cough.
Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
Quit smoking and avoid alcohol consumption.

Side Effects of R-Cinex 600 Tablet

Drowsiness
Dizziness
Headache
Weakness
Muscle pain
Heartburn
Diarrhoea
Gas
Numbness

Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:30 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Drug-Drug Interactions Checker List

SAQUINAVIR
RITONAVIR
ACETAMINOPHEN
HYDROCODONE
DULOXETINE
BUPROPION
DILTIAZEM
ETHAMBUTOL
PYRAZINAMIDE
CHOLECALCIFEROL
ERGOCALCIFEROL

Special Advise

R-Cinex 600 Tablet may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking R-Cinex 600 Tablet.
Your doctor may advise you to get regular liver tests while taking R-Cinex 600 Tablet to check how your liver is functioning.

Disease/Condition Glossary

Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.