Relitrexed-500 Injection 1's

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹8795.5

(Inclusive of all Taxes)

₹1319.3 Cashback (15%)

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Whats That

About Relitrexed-500 Injection

Relitrexed-500 Injection belongs to the group of medicines called folate analogue metabolic inhibitors used alone or in combination with other anti-cancer medicines to treat non-small cell lung cancer and malignant pleural mesothelioma (cancer affecting the lining of the lung).

Relitrexed-500 Injection contains Pemetrexed, which works by blocking the action of substances that may help the cancer cells multiply.

In some cases, Relitrexed-500 Injection may cause side effects such as diarrhoea, tiredness, nausea, vomiting, and loss of appetite. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Relitrexed-500 Injection if you are pregnant or breastfeeding. Relitrexed-500 Injection is not recommended for children below 18 years. Women and men should use effective contraception during treatment with Relitrexed-500 Injection and for 6 and 3 months afterwards. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Relitrexed-500 Injection

Non-small cell lung cancer, malignant pleural mesothelioma.

Directions for Use

Relitrexed-500 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Relitrexed-500 Injection contains Pemetrexed, which belongs to the group of medicines called anti-folate anti-neoplastic agents indicated in the treatment of malignant pleural mesothelioma and non-small cell lung cancer in initial treatment in combination with cisplatin, as maintenance treatment of patients whose disease has not progressed after four cycles of platinum-based first-line chemotherapy and after prior chemotherapy as a single agent. Relitrexed-500 Injection treats cancer by blocking the action of substances that may help the cancer cells multiply.

Storage

Keep Relitrexed-500 Injection out of reach and sight of children.

Side effects of Relitrexed-500 Injection

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Increased Risk Of Infection Due To Low Neutrophil Count

Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
Avoid contact with people who are sick.
Wash your hands regularly with soap and water.
Avoid unpasteurized dairy products.

Low White Blood Cell Count

Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
Get sufficient sleep and manage stress which helps in improving white blood cell count.
Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

Anemia

Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
Consume vitamin C-rich foods as they aid iron absorption.
Limit tea, cocoa, and coffee as these can slow iron absorption.
Exercise regularly; however, do not overdo it.

Sore Throat

Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
Gargle with warm salt water.
Suck on lozenges to increase the production of saliva and soothe your throat.
Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.

Drug Warnings

Do not use Relitrexed-500 Injection if you are allergic to any of its components, pregnant or breastfeeding, or if you have taken or plan to receive yellow fever vaccination. Inform the doctor if you have/had heart disease, kidney problems, have had or are going to have radiation therapy, or have accumulation of fluid around the lungs. Seek immediate medical attention if you experience symptoms of fever or infection; pain, sores, redness or swelling in the mouth; chest pain or a fast heartbeat; allergic reaction (skin rash, burning/prickling sensation, or fever); Stevens-Johnson Syndrome or toxic epidermal necrolysis (severe rash, itching, or blistering); low haemoglobin levels (tiredness, feeling faint, paleness, or becoming easily breathless); low platelet count (bleeding from gums/nose/mouth, bleeding that does not stop, unexpected bruising, reddish or pinkish urine); or blood clot in the blood vessels of the lungs (sudden breathlessness, cough with bloody sputum or intense chest pain).

Drug-Drug Interactions

PemetrexedThalidomide

Severe

PemetrexedTofacitinib

Severe

Drug-Drug Interactions

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PemetrexedThalidomide

Severe

How does the drug interact with Relitrexed-500 Injection:
Taking thalidomide together with Relitrexed-500 Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Relitrexed-500 Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

PemetrexedTofacitinib

Severe

How does the drug interact with Relitrexed-500 Injection:
Taking Tofacitinib with Relitrexed-500 Injection may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Relitrexed-500 Injection and Tofacitinib, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.

PemetrexedMeloxicam

Severe

How does the drug interact with Relitrexed-500 Injection:
Co-administration of Meloxicam and Relitrexed-500 Injection together may increase the levels of Relitrexed-500 Injection in the blood.

How to manage the interaction:
Co-administration of Meloxicam with Relitrexed-500 Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice symptoms like fever, chills, flu-like symptoms, mouth sores, severe diarrhea, or any injuries, call a doctor right away. Do not discontinue any medications without consulting a doctor.

PemetrexedCladribine

Severe

How does the drug interact with Relitrexed-500 Injection:
Taking Cladribine with Relitrexed-500 Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladribine and Relitrexed-500 Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

PemetrexedClozapine

Severe

How does the drug interact with Relitrexed-500 Injection:
Combining Relitrexed-500 Injection with Clozapine can increase the risk of infection.

How to manage the interaction:
Co-administration of Relitrexed-500 Injection with Clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

PemetrexedEtanercept

Severe

How does the drug interact with Relitrexed-500 Injection:
When Etanercept is used with Relitrexed-500 Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Relitrexed-500 Injection and Etanercept together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

PemetrexedInfliximab

Severe

How does the drug interact with Relitrexed-500 Injection:
When Relitrexed-500 Injection is taken with Infliximab, it can enhance the metabolism of Relitrexed-500 Injection. This can reduce the treatment outcome and can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Relitrexed-500 Injection with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

PemetrexedBaricitinib

Severe

How does the drug interact with Relitrexed-500 Injection:
Coadministration of Relitrexed-500 Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Relitrexed-500 Injection and Baricitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Eat a healthy diet and exercise regularly to maintain proper weight.
Avoid smoking and alcohol consumption.
Include vegetables and fruits in your diet.
Avoid fast food, fried, processed food, refined carbs, and added sugar.
Get optimal sleep; rest well.
Drink enough water and eat fibre-rich foods, vegetables and fruits.

Side Effects of Relitrexed-500 Injection

Nausea
Vomiting
Loss of appetite
Tiredness
Pain, redness, swelling or sores in the mouth
Infection
Sore throat
Low white blood cells, haemoglobin levels
Skin rash
Flaking skin

Habit Forming

No

Therapeutic Class

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Relitrexed-500 Injection work?

Relitrexed-500 Injection works by blocking the action of substances that may help the cancer cells multiply.

Does Relitrexed-500 Injection affect fertility?

Relitrexed-500 Injection may affect your ability to have children. Seek advice from the doctor about sperm storage before initiation of therapy. Use effective contraception and avoid fathering a child during treatment and for up to 3 months afterwards.

Does Relitrexed-500 Injection cause bone marrow suppression?

Relitrexed-500 Injection may suppress bone marrow suppression, resulting in cytopenia (low white blood cells, red blood cells, or platelets) and increased risk of infection. The doctor may adjust the dose based on the blood cell count and non-hematologic toxicity.

Why are supplements prescribed while on treatment with Relitrexed-500 Injection?

To lower the chances of side effects during anticancer treatment, your doctor may prescribe supplements like folic acid and vitamin B12 prior to and during treatment with Relitrexed-500 Injection.

Drug-Drug Interactions Checker List

IBUPROFEN

Special Advise

The doctor may advise blood tests to evaluate your liver/kidney function and blood cell count.
Women must use effective contraception during treatment and for six months after receiving the last dose.
Men are advised to use effective contraception during treatment and for three months after the end of the treatment.
You are recommended to take the supplements as advised by the doctor.

Disease/Condition Glossary

Non-small cell lung cancer: It is a disease in which cancer cells form in the tissues of the lungs. The major risk factor for non-small cell lung cancer is smoking. Symptoms include a cough that does not go away and shortness of breath.

Malignant pleural mesothelioma: It is a type of cancer that develops in the mesothelium (a lining that covers the outer surface of organs), predominantly caused by exposure to asbestos. Symptoms of mesothelioma in the lining of the lungs include chest pain, shortness of breath, extreme tiredness, persistent cough, loss of appetite, unexplained weight loss, fever and sweating, particularly at night.