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Written By Divya L , PharmaD
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

DESMOPRESSIN-89MCG

Manufacturer/Marketer :

Xenone Healthcare Pvt Ltd

Consume Type :

NASAL

Return Policy :

Not Returnable

Expires on or after :

About Repressin 0.1 mg/ml Intranasal Solution 5 ml

Repressin 0.1 mg/ml Intranasal Solution 5 ml belongs to the class of 'antidiuretics', primarily used as replacement therapy in central cranial diabetes insipidus, a condition in which the body fails to control water balance, resulting in excessive urination. Repressin 0.1 mg/ml Intranasal Solution 5 ml is also used to manage temporary polyuria (extreme urination) or polydipsia (extreme thirst) after head trauma or surgery in the pituitary gland.

Repressin 0.1 mg/ml Intranasal Solution 5 ml contains Desmopressin, a human-made form (synthetic) of Vasopressin. Vasopressin is an antidiuretic (that controls fluid balance) hormone synthesized in the hypothalamus of the pituitary gland. When your body cannot produce enough vasopressin, Repressin 0.1 mg/ml Intranasal Solution 5 ml is given to replace a low level of vasopressin. It mimics the natural hormone vasopressin and works by reabsorbing water from the kidneys, which controls excessive thirst and urination. Thus, it prevents dehydration. 

Repressin 0.1 mg/ml Intranasal Solution 5 ml is for intranasal use only. Your doctor will decide the dosage depending on your medical condition. The common side effects of Repressin 0.1 mg/ml Intranasal Solution 5 ml include conjunctivitis/red eyes, weakness, headache, nasal congestion/stuffy nose, rhinitis/runny nose, nose bleeds, nausea, upset stomach, abdominal pain, and flushing (sense of warmth) of the face. These side effects may not occur in every patient using this medication and gradually resolve over time. If the side effects persist longer or worsen, please seek a doctor's advice.

Before starting Repressin 0.1 mg/ml Intranasal Solution 5 ml, let your doctor know if you have any medical history of severe kidney disease or hyponatremia (low sodium levels in your body), excessive fluid intake, high blood pressure, heart problems/failure, swelling or scarring of the nasal lining, and illnesses that cause fluid/mineral imbalance. While using Repressin 0.1 mg/ml Intranasal Solution 5 ml, avoid drinking large amounts of fluid, including alcohol, since it could lead to the build-up of water in the body. Pregnant and breastfeeding women should consult their doctor before using Repressin 0.1 mg/ml Intranasal Solution 5 ml. 

Uses of Repressin 0.1 mg/ml Intranasal Solution 5 ml

Central cranial diabetes insipidus, polyuria, and polydipsia.

Directions for Use

Intranasal solution/Nasal spray: Read the instruction leaflet (if provided) carefully before using and prime the nozzle, if required. Blow your nose. Tilt your head back and insert the tip of the nozzle into your nostril. Spray into the nostril while breathing in slightly. When pressing down the pump, apply even pressure and press down quickly to produce a consistent spray. Repeat the same process for another nostril if required. Wipe off the tip with a clean tissue and replace the cap.Nasal drops: Read the instruction leaflet (if provided) carefully and use it as suggested by the doctor. Insert the tip of the dropper into the end of the medicine dispensing tube marked with measurements. Squeeze the dropper until the solution has reached the desired measurement. You can also use a syringe to fill the tube. Hold the tip of the tube, gently insert it into one nostril, and put the other end of the tube into your mouth. Hold your breath, tilt back your head, and blow slowly through your mouth into the tube so the solution reaches your nose.

Medicinal Benefits

Repressin 0.1 mg/ml Intranasal Solution 5 ml is a hormone analogue that contains Desmopressin, a synthetic form of Vasopressin (an antidiuretic hormone that controls fluid balance). Repressin 0.1 mg/ml Intranasal Solution 5 ml mimics the natural hormone vasopressin and works by limiting the amount of water eliminated in the urine, thus controlling excessive thirst and urination. Repressin 0.1 mg/ml Intranasal Solution 5 ml is not indicated for the treatment of nephrogenic diabetes insipidus.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Before starting Repressin 0.1 mg/ml Intranasal Solution 5 ml, let your doctor know if you have any history of allergic reactions to antidiuretic hormones, severe kidney disease, hyponatremia (low sodium levels in your body), excessive fluid intake, high blood pressure, heart failure, illnesses that cause fluid/mineral imbalance (cystic fibrosis), and fluid retention. Please consult your doctor before starting Repressin 0.1 mg/ml Intranasal Solution 5 ml if you are pregnant, planning to conceive or are a breastfeeding mother. Alcohol consumption may interfere with the working of Repressin 0.1 mg/ml Intranasal Solution 5 ml; hence it is advised to limit or avoid its intake. Repressin 0.1 mg/ml Intranasal Solution 5 ml should be used in children only when prescribed by the doctor.

Diet & Lifestyle Advise

  • Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains.
  • Reduce the amount of salt and protein in your diet, which will help your kidneys to produce less urine.
  • Avoid drinking coffee, tea, cola, energy drinks, or other caffeine sources before bedtime since it can lead to increased urination. 
  • Avoid activities that cause dehydration, such as excessive physical exercise or spending time in the heat.
  • Optimal water intake is recommended to prevent dehydration due to excessive urination.

Habit Forming

No

Therapeutic Class

HORMONES

Author Details

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FAQs

Repressin 0.1 mg/ml Intranasal Solution 5 ml contains Desmopressin, a human-made form of vasopressin (antidiuretic hormone). When your body cannot produce enough vasopressin, Repressin 0.1 mg/ml Intranasal Solution 5 ml is used to replace it. It helps treat cranial diabetes insipidus, polyuria, and polydipsia.

Do not use Repressin 0.1 mg/ml Intranasal Solution 5 ml if you have polyuria that has not been diagnosed as diabetes insipidus. It is advised to use the Repressin 0.1 mg/ml Intranasal Solution 5 ml only when the doctor has suggested it for you, depending on your medical condition.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule.

Optimal intake of fluids is recommended to prevent dehydration. However, avoid excess intake of water and other liquids like coffee, tea, cola, and energy drinks during the treatment. Excessive fluid intake while using Repressin 0.1 mg/ml Intranasal Solution 5 ml may lead to a build-up of water, which dilutes the salt in the body leading to serious problems.

Drug-Drug Interactions Checker List

  • LOPERAMIDE
  • CHLORPROPAMIDE
  • GLIBENCLAMIDE
  • CLOFIBRATE
  • NAPROXEN
  • IBUPROFEN
  • CARBAMAZEPINE
  • CHLORPROMAZINE
  • FUROSEMIDE
  • LITHIUM
  • FLUOXETINE
  • SERTRALINE

Special Advise

  • Regular monitoring of electrolytes is essential to rule out chances of fluid imbalance.
  • If you are more frequently urinating than usual, it is advised to consult your endocrinologist to check for any hormonal abnormalities.
  • Your doctor may advise kidney functioning tests to monitor for renal impairment.

Disease/Condition Glossary

Diabetes insipidus: It is a condition in which the body fails to control fluid balance, resulting in excessive urination. It is caused due to following: 

A) Central diabetes insipidus: It is caused when the pituitary gland cannot produce enough vasopressin (an antidiuretic hormone that maintains fluid balance). It is characterized by excessive thirst (polydipsia) and excessive urination (polyuria).

B) Nephrogenic diabetes insipidus: Though you make enough vasopressin, your kidneys may not respond to vasopressin that regulates fluid balance.

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