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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sureshvarma D , MPharma
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Composition :

TOLVAPTAN-15MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

About Resodim 15 Tablet

Resodim 15 Tablet belongs to a group of medicines called vasopressin V2 receptor antagonist used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Additionally, Resodim 15 Tablet is also used to treat autosomal dominant polycystic kidney disease (ADPKD).
 
Resodim 15 Tablet contains ‘tolvaptan’ that works by blocking the effect of vasopressin, resulting in decreased water reabsorption, a net increase in free water excretion (aquaresis) and an increase in serum sodium concentrations. This decrease in free water is not associated with an increased excretion of sodium or potassium ions, the increase in serum sodium concentration is solely a result of  increased urine production
 
You are advised to take Resodim 15 Tablet for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Do not take Resodim 15 Tablet if you are pregnant as it may cause foetal harm. Consult your doctor before taking Resodim 15 Tablet if you are breastfeeding. Resodim 15 Tablet is not recommended for children below 18 years as the efficacy and safety have not been established. Resodim 15 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side-effects.

Uses of Resodim 15 Tablet

Hyponatremia (low sodium levels) and autosomal dominant polycystic kidney disease (ADPKD).

Directions for Use

Swallow Resodim 15 Tablet as a whole with a glass of water, do not crush, break or chew it.

Key Benefits

Resodim 15 Tablet belongs to a group of medicines called vasopressin V2 receptor antagonist. Resodim 15 Tablet is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Besides this, Resodim 15 Tablet is also used to treat autosomal dominant polycystic kidney disease (ADPKD). Resodim 15 Tablet works by blocking the effect of vasopressin, a hormone which is involved in the formation of cysts in ADPKD patients. By blocking the effect of vasopressin, Resodim 15 Tablet slows down the development of cysts in kidneys and reduces the symptoms of the disease. Resodim 15 Tablet antagonises the effect of vasopressin, this results in an increase in free water clearance and decreases urine osmolality due to increased urinary excretion, thereby increases serum sodium concentrations.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Resodim 15 Tablet if you are allergic to any of its contents, if you have raised liver enzymes in the blood, very low blood volume, if there is no urine production, if you cannot tell that you are thirsty. Inform your doctor if you have liver disease, difficulty in urination, diabetes, high levels of uric acid, advanced kidney disease or if you have to restrict fluid intake due to certain medical conditions. Do not take Resodim 15 Tablet if you are pregnant as it may cause foetal harm. Consult your doctor before taking Resodim 15 Tablet if you are breastfeeding. Resodim 15 Tablet is not recommended for children below 18 years as efficacy and safety have not been established. Resodim 15 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. 

Diet & Lifestyle Advise

  • Eat a diet rich in whole grains, vegetables, and fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Manage stress with meditation, yoga, and massage.
  • Drink plenty of fluids.
  • Rehydration beverages that contain electrolytes are also helpful.

Side Effects of Resodim 15 Tablet

  • Dizziness
  • Headache
  • Dry mouth
  • Fatigue
  • Weakness
  • Diarrhoea
  • Thirst
  • Increased urge to urinate

Habit Forming

No

Therapeutic Class

[CARDIOVASCULAR AGENTS]

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Author Details

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FAQs

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • TELITHROMYCIN
  • SULPHAMETHOXAZOLE+TRIMETHOPRIM
  • KETOCONAZOLE
  • ITRACONAZOLE
  • RITONAVIR
  • INDINAVIR
  • SAQUINAVIR
  • NELFINAVIR
  • NEFAZODONE
  • SPIRONOLACTONE
  • VALSARTAN
  • SACUBITRIL
  • HEPARIN

Special Advise

  • Regular monitoring of liver functioning and electrolyte levels while taking Resodim 15 Tablet is advised.
  • Treatment with Resodim 15 Tablet should be started and re-started in a hospital or in the presence of a healthcare professional to monitor the sodium levels in your blood closely.

Disease/Condition Glossary

Hyponatremia: Sodium is an important electrolyte that helps in maintaining water balance in and around the cells. It helps in proper nerve, muscle functioning and maintains stable blood pressure levels. Low levels of sodium in the blood are referred to as hyponatremia. Normal levels of sodium are 135-145 milliequivalance per litre. Hyponatremia occurs when the level is below 135mEq/L. Symptoms include weakness, tiredness, nausea, vomiting, headache, irritability, confusion and muscle spasms.

Autosomal Dominant Polycystic Kidney Disease (ADPKD): It is an inherited disorder in which cysts are developed in the kidney. These cysts are non-cancerous sacs that contain a water-like fluid which puts pressure on the surrounding tissues, leading to reduced kidney function. Symptoms include high blood pressure, swollen abdomen, and back or side pain.

Have a query?

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Alcohol

Safe if prescribed

Avoid consuming alcohol while taking Resodim 15 Tablet as it may cause increased dizziness.

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Pregnancy

Consult your doctor

Resodim 15 Tablet belongs to pregnancy category C. Resodim 15 Tablet is not recommended for use in pregnant women as it may cause foetal harm. Women of childbearing age must use effective contraception while taking Resodim 15 Tablet.

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Breast Feeding

Consult your doctor

Resodim 15 Tablet is not recommended for use in breastfeeding women. Consult your doctor if you are breastfeeding; your doctor will decide whether Resodim 15 Tablet can be taken by breastfeeding mothers or not.

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Driving

Safe if prescribed

Resodim 15 Tablet may cause dizziness, weakness and tiredness. Do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Dose adjustment may be needed. Resodim 15 Tablet should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Consult your doctor

Resodim 15 Tablet should be used with caution in patients with kidney impairment/kidney disease. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Safe if prescribed

Resodim 15 Tablet is not recommended for children below 18 years as efficacy and safety have not been established.

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