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  3. Rexnol Syrup 100 ml

Rexnol Syrup 100 ml, Pack of 1 LIQUID
Not for online sale
Written By Urvashi Bharti , MBBS
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
Know More
COD available

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Whats That

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Composition :

CHLORPHENIRAMINE-4MG + CODEINE-10MG

Manufacturer/Marketer :

Knoll Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Rexnol Syrup

Rexnol Syrup belongs to a class of medication called ‘cough and cold preparations’ primarily used to treat dry cough associated with a common cold or upper respiratory allergies. Coughing (dry or productive) is the body’s way of clearing irritants (like allergens, mucus, or smoke) from airways and preventing infection. There are two types of coughs: Dry cough and chesty cough. A dry cough is tickly and doesn't produce any vicious or thick mucus, while a chesty cough (wet cough) means mucous or sputum is produced to help clear your airways. 

Rexnol Syrup is a combination of two drugs: Chlorpheniramine (antihistamine) and Codeine (cough suppressant). Chlorpheniramine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. Codeine belongs to the class of cough suppressants that blocks the μ-opioid receptor in the brain that produces cough, thereby decreasing the urge to cough.

Take Rexnol Syrup as prescribed by your doctor. Take Rexnol Syrup for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain side effects, including drowsiness, dry mouth, vomiting, blurred vision, constipation, dizziness, or tiredness. Most of these side effects of Rexnol Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Please tell your doctor if you are allergic to Rexnol Syrup or any other medicines. Drink plenty of fluids while taking Rexnol Syrup to loosen mucus and protect yourself from being dehydrated or overheated during exercise. In hot weather, as Rexnol Syrup contains chlorpheniramine, it decreases sweating and increases heatstroke risk. Do not take Rexnol Syrup if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. Rexnol Syrup is not recommended for children below 18 years of age. Do not take Rexnol Syrup if you have taken an MAO inhibitor (anti-depressant medication like Isocarboxazid, Phenelzine, Selegiline, and Tranylcypromine) in the last 14 days, as it may cause life-threatening drug interaction. Rexnol Syrup is a habit-forming drug, and hence there is a risk of dependence on Rexnol Syrup . So, before stopping Rexnol Syrup , contact a doctor as it may cause withdrawal symptoms like anxiety, increased heart rate, tremors, or general unwell feelings.

Uses of Rexnol Syrup

Dry Cough

Directions for Use

It is available in syrup and tablet forms.Tablet: Your doctor will recommend how often you take this medicine based on your medical condition. Do not crush, chew, or break the tablet.Syrup: Shake the bottle well before use. Check the label for directions and take this medicine on an empty stomach or as prescribed by your doctor with the help of a measuring cup provided with the pack.Do not use this medicine unless prescribed by your doctor. Always take it as your doctor told you. Your doctor will advise you on how often to take this medicine on the basis of your medical condition.

Medicinal Benefits

Rexnol Syrup is a combination of two drugs: Chlorpheniramine and Codeine. Chlorpheniramine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps to provide relief from allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness. Codeine belongs to the class of narcotic cough suppressants that block the μ-opioid receptor in the brain that produces cough, thereby decreasing the urge to cough. Rexnol Syrup is used to treat cough associated with a common cold or upper respiratory allergies.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Please tell your doctor if you are allergic to Rexnol Syrup or any other medicines. Do not take Rexnol Syrup for a prolonged time; $ name contains codeine that may lead to mental or physical dependence on Rexnol Syrup . Do not take Rexnol Syrup if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. Rexnol Syrup is not recommended for children below 18 years of age. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, as a dangerous drug interaction could occur. Rexnol Syrup should be taken with extreme caution in patients who have a history of alcoholism or drug abuse. Drink plenty of fluids while taking Rexnol Syrup to loosen mucus and protect yourself from being dehydrated or overheated during exercise. In hot weather, as Rexnol Syrup contains chlorpheniramine, it decreases sweating and increases heatstroke risk. If you have high blood pressure, fits, glaucoma, hyperthyroidism (overactive thyroid), chronic bronchitis, asthma, cough with mucus, cough caused by smoking, chronic bronchitis or emphysema (a lung condition causing shortness of breath), chronic obstructive pulmonary disease (COPD), blockage in stomach or intestines, kidney, liver, heart or urinary problems, inform your doctor before taking Rexnol Syrup .

Drug-Drug Interactions

verifiedApollotooltip
ChlorpheniraminePotassium citrate
Critical
ChlorpheniraminePotassium chloride
Critical

Drug-Drug Interactions

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ChlorpheniraminePotassium citrate
Critical
How does the drug interact with Rexnol Syrup 100 ml:
Taking Rexnol Syrup 100 ml and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Rexnol Syrup 100 ml with Potassium citrate is not recommended as it can lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience any symptoms such as severe stomach pain, bloating, lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ChlorpheniraminePotassium chloride
Critical
How does the drug interact with Rexnol Syrup 100 ml:
Taking Rexnol Syrup 100 ml and Potassium chloride (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Rexnol Syrup 100 ml with Potassium chloride it not recommended as it can lead to an interaction, it can be taken if your doctor has prescribed it. However, if you experience any symptoms such as severe stomach pain, bloating, lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor. Do not discontinue any medications without a doctor's advice.
ChlorpheniramineKetamine
Severe
How does the drug interact with Rexnol Syrup 100 ml:
Co-administration of Rexnol Syrup 100 ml with Ketamine can increase the risk of side effects.

How to manage the interaction:
Taking Rexnol Syrup 100 ml and Ketamine together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, drowsiness, confusion, difficulty concentrating, and breathing difficulty. Avoid activities requiring mental focus such as driving, operating dangerous machinery. Do not discontinue any medications without a doctor's advice.
ChlorpheniramineTopiramate
Severe
How does the drug interact with Rexnol Syrup 100 ml:
Taking Rexnol Syrup 100 ml with Topiramate can increase the risk of side effects including high body temperatures and decreased sweating, sun stroke.

How to manage the interaction:
Although taking Rexnol Syrup 100 ml and Topiramate together can result in an interaction, it can be taken if your doctor has advised it. During warm weather and when exercising, you should drink lots of fluids. If your sweating is less than usual or you have a fever, if you feel lightheaded or dizzy, consult a doctor. Avoid activities requiring mental attention such as driving or operating dangerous machinery. Do not discontinue any medications without a doctor's advice.
ChlorpheniramineMexiletine
Severe
How does the drug interact with Rexnol Syrup 100 ml:
Co-administration of Rexnol Syrup 100 ml with mexiletine may cause the side effects of mexiletine.

How to manage the interaction:
Although taking Rexnol Syrup 100 ml and mexiletine together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
ChlorpheniramineIsocarboxazid
Severe
How does the drug interact with Rexnol Syrup 100 ml:
Co-administration of Rexnol Syrup 100 ml with Isocarboxazid can increase the risk of side effects.

How to manage the interaction:
Taking Rexnol Syrup 100 ml with Isocarboxazid can result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of these symptoms - dizziness, drowsiness, confusion, disorientation, memory problems, blurred vision, dry mouth, constipation, heat intolerance, flushing, decreased sweating, difficulty urinating, rapid heartbeat, - make sure to consult the doctor right away. Do not stop using any medications without talking to a doctor.
ChlorpheniramineEluxadoline
Severe
How does the drug interact with Rexnol Syrup 100 ml:
Taking Rexnol Syrup 100 ml with Eluxadoline can increase the levels of both the medications, which may the risk of constipation and other stomach related problems.

How to manage the interaction:
There may be a possibility of interaction between Rexnol Syrup 100 ml and Eluxadoline, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ChlorpheniramineEthanol
Severe
How does the drug interact with Rexnol Syrup 100 ml:
Taking Rexnol Syrup 100 ml and Ethanol together may increases the risk of side effects.

How to manage the interaction:
Although taking Rexnol Syrup 100 ml and Ethanol together can result in an interaction, it can be taken if your doctor has advised it. Avoid physical activities such as driving or operating machinery. Do not discontinue any medications without a doctor's advice.
ChlorpheniramineIdelalisib
Severe
How does the drug interact with Rexnol Syrup 100 ml:
Taking Rexnol Syrup 100 ml with Idelalisib together can increase the levels of Rexnol Syrup 100 ml which may lead to side effects.

How to manage the interaction:
Although taking Rexnol Syrup 100 ml and Idelalisib together can cause an interaction, it can be taken if your doctor has suggested it. Do not discontinue any medications without consulting the doctor.
ChlorpheniramineSodium oxybate
Severe
How does the drug interact with Rexnol Syrup 100 ml:
Taking Rexnol Syrup 100 ml with Sodium oxybate can enhance the risk of side effects.

How to manage the interaction:
Co-administration of Rexnol Syrup 100 ml with Sodium oxybate can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience- drowsiness, dizziness, lightheadedness, confusion, breathing difficulty, and impairment in thinking, judgment, and motor coordination, consult the doctor. You should take care when getting up from a sitting or lying posture, and avoid operating machinery, driving, or participating in any potentially dangerous activity requiring mental attention and motor coordination for at least six hours after taking sodium oxybate.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid dairy products such as milk, as it may increase mucus production. Also, avoid processed or refined foods to have relief from cough. Instead, replace baked foods, fried foods, white bread, white pasta, French fries, sugary desserts, and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid dry throat while you cough and loosen mucus.
  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content such as pears, watermelon, peaches and pineapples.

Habit Forming

Yes

Therapeutic Class

COUGH AND COLD PREPARATIONS

Rexnol Syrup Substitute

Substitutes safety advice

Product Substitutes

Author Details

Doctor image

Written By

Urvashi Bharti

MBBS

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:33 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Rexnol Syrup is a combination of two drugs, namely; Chlorpheniramine and Codeine, which relieves dry cough. Chlorpheniramine Maleate is an antihistaminic that blocks the action of a chemical messenger (histamine), which may trigger a cough due to allergy. Codeine is a cough suppressant. It suppresses cough by reducing the activity of the cough centre in the brain.

Do not take Rexnol Syrup with 'alprazolam' as co-administration of these two medicines may increase adverse effects such as sedation, respiratory depression, coma, and death. However, please consult a doctor before taking Rexnol Syrup with other medicines.

Rexnol Syrup is excreted in breast milk and may cause drowsiness, breathing problems, or death in a nursing baby. Therefore, if breastfeeding, please inform your doctor before taking Rexnol Syrup . Your doctor will weigh the benefits and potential risks before prescribing them.

Rexnol Syrup is not recommended for children below 18 years of age as a misuse of Rexnol Syrup in children may lead to serious adverse effects. Codeine in Rexnol Syrup may cause life-threatening respiratory depression and death in children who recently had surgery to remove the tonsils or adenoids.

Rexnol Syrup may be used to provide relief from allergic symptoms such as sneezing, runny nose, throat irritation or watery eyes. Rexnol Syrup contains Chlorpheniramine, an anti-allergic drug that works by blocking the action of histamine, a substance responsible for causing allergic reactions.

Rexnol Syrup is unsafe to use in pregnancy. Rexnol Syrup contains codeine, If you use Rexnol Syrup while pregnant, your baby could become dependent on codeine. This can cause life-threatening withdrawal symptoms in the baby after it is born.

Yes, codeine in Rexnol Syrup may cause mental or physical dependence if used for prolonged periods. Therefore, take Rexnol Syrup only in dose and duration as advised by your doctor.

Drug-Drug Interactions Checker List

  • DIPHENHYDRAMINE
  • CETIRIZINE
  • BROMPHENIRAMINE
  • FEXOFENADINE
  • DEXTROMETHORPHAN
  • DULOXETINE
  • SERTRALINE
  • PAROXETINE
  • TRAZODONE
  • HYDROCODONE
  • BUPROPION
  • MORPHINE
  • OXYCODONE
  • ALPRAZOLAM
  • FLUVOXAMINE
  • DIAZEPAM
  • LORAZEPAM
  • NITRAZEPAM
  • PHENYTOIN
  • CLONAZEPAM
  • CARBAMAZEPINE

Special Advise

  • Do not take Rexnol Syrup for a prolonged time as it may lead to mental or physical dependence on Rexnol Syrup .
  • To avoid getting addicted to this drug, take it only in prescribed quantities and as directed by your doctor. Do not self-medicate.
  • Rexnol Syrup causes drowsiness. Avoid doing activities that require your complete focus and attention, like driving when on this drug.
  • An abrupt stoppage of Rexnol Syrup can lead to significant withdrawal symptoms. Always discuss with your doctor about decreasing the dosage before completely stopping its usage.
  • Avoid consuming alcohol while on this medication, as it can lead to dangerous side effects.
  • Rexnol Syrup is unsafe for usage if you're pregnant or plan to get pregnant and breastfeed. Discuss with your doctor in such situations about changing/replacing the medicine with safer alternatives.

Disease/Condition Glossary

Cough: Coughing is the body’s way of clearing irritants (like allergens, mucus, or smoke) from airways and preventing infection. Coughs may be dry or productive. A productive cough (wet cough) brings sputum (phlegm, mucus, and other matter) from the lungs. Cough is commonly caused as a response to allergy or viral infection but coughing up mucus is possibly an indication of infection in the respiratory tract. If you are coughing thick, solid white mucus, it indicates you may have a bacterial infection in the airways. If the mucus is clear or light-coloured, it indicates you may have allergies or minor infections in the respiratory tract, and yellow or green mucus indicates a respiratory infection.

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