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  3. Rioteph 0.5mg Tablet 10's

Rioteph 0.5mg Tablet 10's, Pack of 10 TabletS
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Sureshvarma D , MPharma
Non returnable*
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Composition :

RIOCIGUAT-0.50MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Rioteph 0.5mg Tablet

Rioteph 0.5mg Tablet belongs to the class of medications called soluble guanylate cyclase stimulators. It is also used to treat adults with Pulmonary Arterial Hypertension (PAH), alone or in combination with other medications. Pulmonary hypertension is a type of high blood pressure that affects the arteries in your lungs and the right side of your heart.

Rioteph 0.5mg Tablet contains ‘Riociguat’. It works by relaxing the blood vessels in the lungs. This leads to the relaxation or widening of those vessels. Relaxing and widening the blood vessels in the lungs decreases the pulmonary blood pressure to the heart and improves its function. This reduces blood pressure in the lungs, which generally results in the ability to be more active.

Rioteph 0.5mg Tablet is taken dose and duration as advised by the doctor. Rioteph 0.5mg Tablet may be prescribed alone or in combination with other blood pressure-lowering medicines depending upon your blood pressure levels. In some cases, Rioteph 0.5mg Tablet can cause side effects like headache, diarrhoea, decreased blood pressure, dizziness, vomiting, nausea, anaemia (low number of red blood cells), gastro-oesophageal reflux disease, and constipation. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Inform your doctor if you have had an allergic reaction to Rioteph 0.5mg Tablet or any ingredients in it. Let your doctor know if you have any liver disease, kidney disease, heart failure, heart valve problem or history of a heart attack. Pregnant or breastfeeding women should also consult their doctor for advice before taking this medicine. You must closely monitor your blood pressure if you have ever had a stroke or heart attack or currently taking other blood pressure-lowering pills. It is advised to continue taking this drug and not stop taking it suddenly without consulting your doctor. Keep your doctor informed about your health condition and all the medicines you take before taking Rioteph 0.5mg Tablet to rule out any side effects.

Uses of Rioteph 0.5mg Tablet

Pulmonary hypertension

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Rioteph 0.5mg Tablet  belongs to the class of medications called soluble guanylate cyclase stimulators. Cyclic guanosine monophosphate (cyclic GMP) is a substance produced in the lungs and other parts of the body by an enzyme called guanylate cyclase in response to nitric oxide. Cyclic GMP causes the blood vessels (arteries) to relax and widen. Riociguat increases guanylate cyclase activity in two ways so that more cyclic GMP is available for the blood vessels inside the lungs. This leads to relaxation or widening of those vessels. Relaxing and widening the blood vessels in the lungs decreases the pulmonary blood pressure to the heart and improves its function. This reduces blood pressure in the lungs, which generally results in the ability to be more active.

Storage

Store in a cool and dry place away from sunlight
Side effects of Rioteph 0.5mg Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug Warnings

Inform your doctor if you have had an allergic reaction to Rioteph 0.5mg Tablet or any ingredients in it. Let your doctor know if you have any liver disease, kidney disease, heart failure, heart valve problem or history of a heart attack. Pregnant or breastfeeding women should also consult their doctor for advice before taking this medicine. You must closely monitor your blood pressure if you have ever had a stroke, or heart attack or currently taking other blood pressure-lowering pills. Keep your doctor informed about your health condition and all the medicines you take before taking Rioteph 0.5mg Tablet to rule out any side effects. Complete the course strictly as suggested by the doctor, even if you feel better, to avoid disease recurrence. Do not drive or operate machinery since Rioteph 0.5mg Tablet may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Avoid consumption of alcohol with Rioteph 0.5mg Tablet as it may increase the risk of low blood pressure. Rioteph 0.5mg Tablet is not recommended in patients younger than 18 years of age.

Drug-Drug Interactions

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RiociguatDipyridamole
Critical
RiociguatSildenafil
Critical

Drug-Drug Interactions

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RiociguatDipyridamole
Critical
How does the drug interact with Rioteph 0.5mg Tablet:
Taking Dipyridamole with Rioteph 0.5mg Tablet may lower blood pressure.

How to manage the interaction:
Taking Dipyridamole with Rioteph 0.5mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion Do not discontinue any medications without consulting a doctor.
RiociguatSildenafil
Critical
How does the drug interact with Rioteph 0.5mg Tablet:
Co-administration of Sildenafil with Rioteph 0.5mg Tablet may lower the blood pressure.

How to manage the interaction:
Taking Rioteph 0.5mg Tablet and Sildenafil together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RiociguatAminophylline
Critical
How does the drug interact with Rioteph 0.5mg Tablet:
Coadministration of Aminophylline with Rioteph 0.5mg Tablet may significantly lower your blood pressure.

How to manage the interaction:
Taking Aminophylline with Rioteph 0.5mg Tablet can cause an interaction, however, it can be taken only if a doctor has advised it. If you experience dizziness, lightheadedness, shortness of breath, fainting, flushing, headache, and nasal congestion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RiociguatAmyl nitrite
Critical
How does the drug interact with Rioteph 0.5mg Tablet:
Using Amyl Nitrite with Rioteph 0.5mg Tablet may cause excessively low blood pressure.

How to manage the interaction:
Taking Amyl nitrite with Rioteph 0.5mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion. Do not discontinue any medications without consulting a doctor.
RiociguatIsosorbide dinitrate
Critical
How does the drug interact with Rioteph 0.5mg Tablet:
Taking Rioteph 0.5mg Tablet with Isosorbide dinitrate may lead to excessively low blood pressure.

How to manage the interaction:
Taking Isosorbide dinitrate with Rioteph 0.5mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
RiociguatTadalafil
Critical
How does the drug interact with Rioteph 0.5mg Tablet:
Taking Tadalafil with Rioteph 0.5mg Tablet may increase the risk or severity of lower the blood pressure.

How to manage the interaction:
Taking Rioteph 0.5mg Tablet with Tadalafil is generally not recommended as it can lead to an interaction, but it can be taken together if prescribed by a doctor. However, if you experience dizziness, headache, and nasal congestion consult a doctor. Do not discontinue any medications without consulting a doctor.
RiociguatAvanafil
Critical
How does the drug interact with Rioteph 0.5mg Tablet:
Taking Avanafil with Rioteph 0.5mg Tablet may significantly lower blood pressure.

How to manage the interaction:
Taking Rioteph 0.5mg Tablet with Avanafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion Do not discontinue any medications without consulting a doctor.
RiociguatTheophylline
Critical
How does the drug interact with Rioteph 0.5mg Tablet:
Co-administration of Theophylline with Rioteph 0.5mg Tablet can increase the risk of low blood pressure.

How to manage the interaction:
Taking Theophylline with Rioteph 0.5mg Tablet is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, flushing (a sudden reddening of the face), headache, and nasal congestion (stuffy nose). Do not discontinue any medications without consulting a doctor.
RiociguatVardenafil
Critical
How does the drug interact with Rioteph 0.5mg Tablet:
Taking Vardenafil with Rioteph 0.5mg Tablet may significantly lower the blood pressure.

How to manage the interaction:
Taking Rioteph 0.5mg Tablet with Vardenafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion. Do not discontinue any medications without consulting a doctor.
RiociguatNitroprusside
Critical
How does the drug interact with Rioteph 0.5mg Tablet:
Coadministration of Nitroprusside with Rioteph 0.5mg Tablet can increase the risk of low blood pressure.

How to manage the interaction:
Taking Nitroprusside with Rioteph 0.5mg Tablet is avoided, but it can be taken when prescribed by your doctor. However, contact your doctor immediately if you experience any side effects such as dizziness, lightheadedness, headache, and nasal congestion. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Reduce sodium intake in your diet to maintain your blood pressure.
  • Eat natural and healthy foods by cutting down on high-sodium processed foods.
  • Lose those extra pounds since being obese can be a risk factor for hypertension.
  • Exercise regularly to maintain good heart health.
  • Avoid smoking and alcohol intake.
  • Chronic stress may also cause high blood pressure. Therefore, avoid stress triggers and make time to relax and do activities you enjoy.
  • Try to include heart-healthy omega-3 fatty acids-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Rioteph 0.5mg Tablet Substitute

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Sureshvarma D

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:40 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Special Advise

  • Keep a check on your daily blood pressure, and if you notice any fluctuations, please consult a doctor.
  • Your doctor may ask you to undergo blood and urine tests if you suffer from vomiting or dehydration.
  • If you have diabetes, using Rioteph 0.5mg Tablet may affect your blood sugar levels. Inform your doctor so that you may adjust your diabetes medication accordingly.
  • Your dietician may prescribe you a suitable exercise program and diet to manage your blood pressure.
  • Your doctor may also suggest liver function tests since the Rioteph 0.5mg Tablet may cause a change in liver enzymes.
  • may adjust your diabetes medication

Disease/Condition Glossary

Pulmonary hypertension is a type of high blood pressure that affects arteries in the lungs and the heart. Pulmonary hypertension affects arteries in the lungs and the right side of the heart.

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