Ryzodeg 100IU/ml Penfill 3 ml belongs to the class of medications called ‘antidiabetics’ primarily used for the treatment of both type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in adults and children. In Diabetes Mellitus Type 1, the body does not produce enough insulin to regulate blood sugar levels. On the other hand, in Diabetes Mellitus type 2, either the body stops producing enough insulin (a hormone that helps lower blood sugar levels), or there is resistance to insulin action. As a result, insulin is produced in large quantities, but it is not capable of operating on the body's organs.

Ryzodeg 100IU/ml Penfill 3 ml is a combination of two drugs, namely, Insulin Aspart and Insulin Degludec. Insulin aspart is a fast-acting or short-acting form of insulin that helps lower blood sugar levels after food intake. Insulin degludec is a long-acting form of insulin which begins working after 60 minutes and is a long-acting insulin preparation (lasts for more than 24 hours). Ryzodeg 100IU/ml Penfill 3 ml stimulates the recovery of sugar in muscle and fat cells and suppresses sugar production in the liver. Together, Ryzodeg 100IU/ml Penfill 3 ml confirm rapid and stable sugar control by helping reuptake of sugar in fat cells and muscle, and suppressing the creation of sugar in the liver.

Take Ryzodeg 100IU/ml Penfill 3 ml as prescribed by your doctor. You are advised to take Ryzodeg 100IU/ml Penfill 3 ml for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience rash, injection site allergic reaction, weight gain, oedema (tissue swelling or fluid overload), lipodystrophy (skin thickening or pits at the injection site), hypoglycemia (low blood glucose level), itching. Most of these side effects of Ryzodeg 100IU/ml Penfill 3 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking Ryzodeg 100IU/ml Penfill 3 ml of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Do not take Ryzodeg 100IU/ml Penfill 3 ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. Along with Ryzodeg 100IU/ml Penfill 3 ml, you should take a healthy diet, do regular exercise, and maintain weight as advised by your doctor. Ryzodeg 100IU/ml Penfill 3 ml is a cold chain medicine, and so it must be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer of the fridge.

Ryzodeg 100IU/ml Penfill 3 ml belongs to the class of medications called ‘antidiabetics’ primarily used for the treatment of both type 1 and type 2 diabetes mellitus. Ryzodeg 100IU/ml Penfill 3 ml is a combination of two drugs, namely, Insulin Aspart and Insulin Degludec. Ryzodeg 100IU/ml Penfill 3 ml contains insulin aspart, which is a fast-acting form of insulin that helps lower blood sugar levels after food intake. Ryzodeg 100IU/ml Penfill 3 ml contains insulin degludec, which is a prolonged action form of insulin. It typically begins working after 60 minutes and is a long-acting insulin preparation (lasts for more than 24 hours). Together, they confirm rapid and stable sugar control by helping reuptake sugar in fat and muscle, and cells and suppressing the creation of sugar in the liver. 

• Rashes
• Injection site allergic reaction
• Weight gain
• Edema (swelling)
• Lipodystrophy (skin thickening or pits at the injection site)
• Hypoglycemia (low blood glucose level)
• Itching

Ryzodeg 100IU/ml Penfill 3 ml is for subcutaneous (under the skin) use only. However, in rare cases, it can be given via infusion intravenously under medical supervision. If you are changing the insulin brand or injecting your insulin by another method, it should be done under strict medical supervision. Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. The first hyperglycemia symptoms (high blood sugar level) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite and acetone odour of the breath. You should closely monitor these symptoms. Symptoms like heart failure, weight gain and oedema (fluid deposition in tissue) should not be overruled. It is advisable not to consume alcohol as it may either increase or decrease your blood glucose level. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. Ryzodeg 100IU/ml Penfill 3 ml may decrease the level of potassium, leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death. Do not take Ryzodeg 100IU/ml Penfill 3 ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs.

Drug-Drug Interaction: Ryzodeg 100IU/ml Penfill 3 ml may have an interaction with pain killers (aspirin), antibiotics (isoniazid, pentamidine, ciprofloxacin), blood sugar enhancing pills (glucagon), male hormone testosterone analogue (danazol), antidiabetics (metformin), lipid-lowering pills (reserpine, niacin), blood pressure-lowering medicines (atenolol, acebutolol, metoprolol), thyroid hormones (levothyroxine), an antidepressant (fluoxetine, lithium), female sex hormones (progestogen, estrogen).

Drug-Food Interaction: Ryzodeg 100IU/ml Penfill 3 ml may interact with an ayurvedic, homeopathy, Unani, herbal supplements, or OTC items. Tell your doctor if you are using these products. Try to avoid alcoholic beverages with Ryzodeg 100IU/ml Penfill 3 ml as it may increase or decrease your blood sugar level.

Drug-Disease Interaction: Ryzodeg 100IU/ml Penfill 3 ml should not be given to patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycemia), and low potassium level (hypokalaemia).

• ASPIRIN
• ISONIAZID
• PENTAMIDINE
• CIPROFLOXACIN
• GLUCAGON
• DANAZOL
• METFORMIN
• RESERPINE
• NIACIN
• ATENOLOL
• ACEBUTOLOL
• METOPROLOL
• LEVOTHYROXINE
• FLUOXETINE
• LITHIUM
• PROGESTERONE
• ESTROGEN

• Exercise may lower your body’s need for insulin during and for some time after the physical activity.
• Exercise may also speed up an insulin dose effect, especially if the exercise involves the injection site area (for example, the leg should not be used for injection just before running). 
• Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise. 
• Avoid eating sugar food and prefer food cooked food low in calories.
• When travelling across more than 2 time zones, you should talk to your doctor about your insulin schedule adjustments.

• Your doctor may tell you to have a regular potassium level as prolonged administration causes a life-threatening hypokalemia condition (low potassium). 
• Store Ryzodeg 100IU/ml Penfill 3 ml between 2-8 degree celsius temperature only. Do not store Ryzodeg 100IU/ml Penfill 3 ml in the freezer. 

Type 1 diabetes mellitus: In type 1 diabetes mellitus, our body does not make insulin (the hormone which helps to decrease sugar levels in the blood) to control blood sugar levels.

Type 2 diabetes mellitus: In type 2 diabetes mellitus, either the body stops producing enough insulin, or there is resistance to the action of insulin. As a result, insulin is produced in sufficient amounts but is unable to act on the tissues of the organs.