S-PPI-L Capsule 15's belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD). Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus); this causes acidity, pain and heartburn. Symptoms include heartburn, sour or bitter taste in the mouth and difficulty swallowing.

S-PPI-L Capsule 15's contains Esomeprazole and Levosulpiride. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, S-PPI-L Capsule 15's helps in preventing acid reflux, thereby providing relief from acidity and heartburn.

You are advised to take S-PPI-L Capsule 15's for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as headache, abdominal pain, constipation, diarrhoea, flatulence, nausea and vomiting. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Inform your doctor before taking S-PPI-L Capsule 15's if you have a history of gastrointestinal bleeding or intestinal obstruction. On long-term treatment, S-PPI-L Capsule 15's may increase the risk of bone fractures. Consult your doctor if you are pregnant or breastfeeding. S-PPI-L Capsule 15's may cause drowsiness and dizziness, so drive only if you are alert. S-PPI-L Capsule 15's should not be given to children as safety has not been established. Avoid consuming alcohol along with S-PPI-L Capsule 15's as it could lead to increased drowsiness and can elevate the production of stomach acid.

S-PPI-L Capsule 15's belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD). S-PPI-L Capsule 15's is a combination of two drugs, namely: Esomeprazole (proton pump inhibitor) and Levosulpiride (prokinetic agent). Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, S-PPI-L Capsule 15's helps in preventing acid reflux, thereby providing relief from acidity and heartburn.

• Headache
• Abdominal pain
• Flushing
• Dry mouth
• Constipation
• Diarrhoea
• Flatulence
• Nausea
• Vomiting

Do not take S-PPI-L Capsule 15's if you are allergic to any of its contents, if you are taking nelfinavir (anti-HIV), if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment. Inform your doctor before taking S-PPI-L Capsule 15's if you have severe liver or kidney problems; if you are due to have Chromogranin A test; if you experience unexplained weight loss, stomach pain, indigestion, vomit food or blood, or if you pass black stools. On long-term treatment, S-PPI-L Capsule 15's may increase the risk of bone fractures. Do not take S-PPI-L Capsule 15's if you are pregnant or breastfeeding. S-PPI-L Capsule 15's may cause dizziness and drowsiness, so drive only if you are alert. S-PPI-L Capsule 15's should not be given to children as safety has not been established. Avoid consuming alcohol along with S-PPI-L Capsule 15's as it could lead to increased drowsiness and can elevate the production of stomach acid. 

Drug-Drug Interactions: S-PPI-L Capsule 15's may interact with painkillers (aspirin, naproxen), anti-HIV (atazanavir), blood thinner (clopidogrel, warfarin, cilostazol), anti-fungal (ketoconazole, itraconazole, voriconazole), anti-cancer (erlotinib, methotrexate), anti-depressant (citalopram, imipramine, clomipramine, duloxetine), anti-anxiety (diazepam), anti-convulsant (phenytoin), gastroprokinetic agent (cisapride), a drug used to treat heart problems (digoxin), immunosuppressant (tacrolimus), anti-tuberculosis (rifampicin).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interaction: Inform your doctor if you have epilepsy, mania, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, or hypomagnesemia (low levels of magnesium).

• ASPIRIN
• NAPROXEN
• ATAZANAVIR
• CLOPIDOGREL
• WARFARIN
• CILOSTAZOL
• KETOCONAZOLE
• ITRACONAZOLE
• VORICONAZOLE
• ERLOTINIB
• METHOTREXATE
• CITALOPRAM
• IMIPRAMINE
• CLOMIPRAMINE
• DULOXETINE
• DIAZEPAM
• PHENYTOIN
• CISAPRIDE
• DIGOXIN
• TACROLIMUS
• RIFAMPICIN

• Eat smaller meals more often.
• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
• Maintain a healthy weight by regular exercising.
• Avoid lying down after eating as it causes acid reflux.
• Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
• Practise relaxation techniques and avoid stress by doing yoga or meditation.
• Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
• Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

• S-PPI-L Capsule 15's may cause changes in blood tests for checking liver functioning. Inform the person doing the tests that you are taking S-PPI-L Capsule 15's.
• Inform your doctor before taking S-PPI-L Capsule 15's if you are due to have Chromogranin A test.

Gastroesophageal reflux disease (GERD): The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, heartburn and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn and acidity. Symptoms include heartburn, sour or bitter taste in the mouth and difficulty swallowing.