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Written By Sureshvarma D , MPharma
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ORAL

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Apr-24

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About Sacuval 100 Tablet 10's

Sacuval 100 Tablet 10's belongs to a class of cardiovascular agents that is used in the treatment of heart failure. It helps to reduce the risk of death and hospitalization in adults with chronic heart failure. Also, it can be used in children 1 to less than 18 years old to treat heart failure. Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should.

Sacuval 100 Tablet 10's is a combination of two medicines: Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. Together, Sacuval 100 Tablet 10's helps in the treatment of heart failure.

Take Sacuval 100 Tablet 10's with or without food or as directed by your doctor. Do not crush, chew or break the tablet, swallow it as a whole with a glass of water. You are advised to take Sacuval 100 Tablet 10's for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as cough, dizziness, nausea, diarrhea, weakness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Sacuval 100 Tablet 10's for as long as your doctor has prescribed it. Try not to stop taking it on your own as it may cause a sudden increase the blood pressure, chest pain, or heart attack.  Do not be reluctant to speak with your doctor if you experience any difficulty while taking Sacuval 100 Tablet 10's. Do not take Sacuval 100 Tablet 10's with ACE inhibitors (such as captopril, enalapril) since the risk of side effects may increase. Do not take Sacuval 100 Tablet 10's for at least 36 hours before or after taking an ACE inhibitor drug. Inform your doctor before taking Sacuval 100 Tablet 10's if you have kidney or liver problems, if you are pregnant or breastfeeding, or if you have a history of hereditary angioedema (rapid oedema or swelling beneath the area of skin).

Uses of Sacuval 100 Tablet 10's

Heart failure.

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.Suspension: Shake the suspension bottle well before use. Check the label for directions and take it with or without food with a measuring cup in the dose and duration prescribed by the doctor.

Medicinal Benefits

Sacuval 100 Tablet 10's is a combination of two medicines Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. Sacuval 100 Tablet 10's helps in the treatment of certain types of heart failure. It may also help you to live longer and lowers the frequency of hospitalizations for heart failure.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Sacuval 100 Tablet 10's

  • Cough
  • Dizziness
  • Diarrhea
  • Fainting
  • Headache
  • Nausea
  • Stomach pain
  • Vertigo (sensation of feeling off-balance)
  • Weakness

Drug Warnings

Keep your doctor informed if you have kidney or liver diseases. Discuss with your doctor if you are taking any other medicines along with Sacuval 100 Tablet 10's. Avoid smoking and alcohol consumption. Pregnant women and breastfeeding women should consult their doctor before taking Sacuval 100 Tablet 10's. A prolonged intake of Sacuval 100 Tablet 10's can cause an altered potassium level so, regular monitoring of potassium is required. Driving and operating heavy machinery should not be done as it may cause dizziness and drowsiness. Orthostatic hypotension (sudden lowering of blood pressure n standing) might occur, so patients using Sacuval 100 Tablet 10's should get up with caution. Speak to your doctor if you have diabetes before taking Sacuval 100 Tablet 10's. Inform your doctor about your current medicines such as aliskiren (medication to treat high blood pressure), any other heart or blood pressure medicines, lithium, mineral supplements that contain potassium. Inform your doctor if you feel light-headed or have little or no urination, rapid weight gain, swelling in your hands, feet, or ankles after taking Sacuval 100 Tablet 10's.

Drug-Drug Interactions

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ValsartanAliskiren
Critical
ValsartanFosinopril
Severe

Drug-Drug Interactions

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ValsartanAliskiren
Critical
How does the drug interact with Sacuval 100 Tablet:
Using Aliskiren together with Sacuval 100 Tablet may increase the risk of serious side effects (kidney problems, low blood pressure, or high potassium levels).

How to manage the interaction:
Taking Sacuval 100 Tablet with Aliskiren is not advised as it can result in an interaction, it can be taken if a doctor has advised it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
ValsartanFosinopril
Severe
How does the drug interact with Sacuval 100 Tablet:
Coadministration of Fosinopril and Sacuval 100 Tablet can increase the risk or severity of side effects (kidney problems, low blood pressure or high potassium levels in the body).

How to manage the interaction:
Although taking Fosinopril together with Sacuval 100 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanQuinapril
Severe
How does the drug interact with Sacuval 100 Tablet:
The use of Quinapril and Sacuval 100 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Quinapril together with Sacuval 100 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanPerindopril
Severe
How does the drug interact with Sacuval 100 Tablet:
Coadministration of Perindopril with Sacuval 100 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Perindopril together with Sacuval 100 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanPotassium iodide
Severe
How does the drug interact with Sacuval 100 Tablet:
Coadministration of Potassium iodide and Sacuval 100 Tablet may significantly increase potassium levels in the blood, which in severe cases can lead to kidney failure.

How to manage the interaction:
Although taking Potassium iodide together with Sacuval 100 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanBenazepril
Severe
How does the drug interact with Sacuval 100 Tablet:
Coadministration of Benazepril and Sacuval 100 Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Sacuval 100 Tablet and Benazepril, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact a doctor. Do not discontinue any medications without a doctor's advice.
ValsartanLisinopril
Severe
How does the drug interact with Sacuval 100 Tablet:
Coadministration of Lisinopril and Sacuval 100 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Lisinopril together with Sacuval 100 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanLithium
Severe
How does the drug interact with Sacuval 100 Tablet:
Coadministration of Lithium and Sacuval 100 Tablet increase the blood levels of lithium.

How to manage the interaction:
Although taking Lithium together with Sacuval 100 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and/or increased urination, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanTriamterene
Severe
How does the drug interact with Sacuval 100 Tablet:
The use of Triamterene and Sacuval 100 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Triamterene together with Sacuval 100 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medication without consulting a doctor.
ValsartanEnalapril
Severe
How does the drug interact with Sacuval 100 Tablet:
Combine use of Enalapril and Sacuval 100 Tablet can increase the effect of Sacuval 100 Tablet.

How to manage the interaction:
Although taking Enalapril together with Sacuval 100 Tablet may result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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SACUBITRIL-49MG+VALSARTAN-51MGPotassium rich foods
Moderate

Drug-Food Interactions

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SACUBITRIL-49MG+VALSARTAN-51MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Co-administration of Sacuval 100 Tablet along with moderate-to-high dietary potassium intake, especially salt substitutes may lead to high potassium levels in the blood. Avoid taking potassium-containing salt substitutes or over-the-counter potassium supplements along with Sacuval 100 Tablet as this can lead to high potassium levels in blood. However, if you experience weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs, consult a doctor.

Diet & Lifestyle Advise

  • You are advised to consume low salt and low-fat diet while taking Sacuval 100 Tablet 10's.
  • Regular exercise is also recommended to complement treatment with Sacuval 100 Tablet 10's.
  • Eat a diet rich in whole grains, vegetables, fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Managing stress with meditation, yoga, massage would also help in treating high blood pressure.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

Sacuval 100 Tablet 10's Substitute

Substitutes safety advice
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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ASPIRIN
  • ROSUVASTATIN
  • ATORVASTATIN
  • INSULIN DETEMIR
  • METOPROLOL
  • BUDESONIDE
  • FORMOTEROL

Special Advise

  • Regularly monitor blood pressure levels to prevent hypotension (low blood pressure).
  • Get up slowly while rising from a lying or sitting position as Sacuval 100 Tablet 10's may cause dizziness.
  • Keep your doctor informed about your health/disease conditions and the medicines you are taking.

Disease/Condition Glossary

Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should. Heart failure may occur due to certain conditions like high blood pressure, swelling or damage of heart muscle, faulty heart valves, or narrow arteries in the heart. Symptoms of heart failure include shortness of breath, tiredness, fast heartbeat, and swollen legs. 

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