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Reviewed By Sureshvarma D , MPharma
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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About SAFEGUARD 50MG TABLET

SAFEGUARD 50MG TABLET belongs to a class of non-steroidal anti-inflammatory drugs used to reduce pain and swelling in the joints associated with conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (pain and stiffness in the backbone). Arthritis is a condition that causes swelling of one or more joints resulting in pain and stiffness of joints that worsen over time. The arthritis symptoms include joint pain, stiffness, redness, tenderness, swelling in and around joints, and reduced movement of joints.

SAFEGUARD 50MG TABLET is a combination drug containing diclofenac and misoprostol. Diclofenac works by blocking the chemical effect of an enzyme called cyclo-oxygenase (COX), which produces prostaglandins (mediators of pain and inflammation) that are responsible for the sense of pain and inflammation (redness and swelling). Misoprostol is a prostaglandin that helps to protect the stomach from diclofenac's irritating effects. It works by protecting the stomach lining by reducing the amount of acid in contact with it.

Take SAFEGUARD 50MG TABLET as prescribed by your doctor. Depending on your medical conditions, you are advised to take SAFEGUARD 50MG TABLET for as long as your doctor has prescribed it for you. You may experience diarrhoea, stomach/abdominal pain, nausea, heartburn, drowsiness, and dizziness. Most of the side effects of SAFEGUARD 50MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before using the SAFEGUARD 50MG TABLET, tell your doctor if you have had a heart attack or stroke, stomach or bowel disorder, liver disease, porphyria ( inherited blood disorder), asthma, high blood pressure, diabetes, and stomach or intestinal bleeding. Do not take SAFEGUARD 50MG TABLET if you are a pregnant or breastfeeding woman. Consumption of alcohol should be avoided during the treatment with SAFEGUARD 50MG TABLET as it may lead to an increased risk of liver damage. SAFEGUARD 50MG TABLET is not recommended for use in children. Limit alcoholic beverages while on this medication.

Uses of SAFEGUARD 50MG TABLET

Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

SAFEGUARD 50MG TABLET is used to treat aches and pains and musculoskeletal and joint pain problems due to arthritis. SAFEGUARD 50MG TABLET contains diclofenac and misoprostol. Diclofenac works by blocking the chemical effect of an enzyme called cyclo-oxygenase (COX), which produces prostaglandins (mediators of pain and inflammation) that are responsible for the sense of pain and inflammation (redness and swelling). Misoprostol is a prostaglandin that helps to protect the stomach from diclofenac's irritating effects. It works by protecting the stomach lining by reducing the amount of acid in contact with it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of SAFEGUARD 50MG TABLET

  • Diarrhea
  • Stomach/abdominal pain
  • Nausea
  • Heartburn
  • Difficulty sleeping
  • Ulcers in the stomach or intestines
  • Drowsiness
  • Dizziness
  • Indigestion

Drug Warnings

Consumption of alcohol should be avoided during the treatment with SAFEGUARD 50MG TABLET. Patients with stomach ulcers, gastric bleeding, heart failure, and high blood pressure should not take SAFEGUARD 50MG TABLET. If pregnant or breastfeeding, do not take SAFEGUARD 50MG TABLET without talking with the doctor. SAFEGUARD 50MG TABLET is not recommended for children below 18 years old. Seek medical help immediately if you have signs of a heart attack or stroke. Stop using SAFEGUARD 50MG TABLET and call your doctor immediately if you notice heart problems, kidney problems, liver problems, or stomach bleeding signs.

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
MisoprostolDinoprostone
Severe

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
How does the drug interact with Safeguard 50mg Tablet:
Co-administration of Safeguard 50mg Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Safeguard 50mg Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
MisoprostolDinoprostone
Severe
How does the drug interact with Safeguard 50mg Tablet:
Combined use of Safeguard 50mg Tablet and Dinoprostone can affect the metabolism of Safeguard 50mg Tablet.

How to manage the interaction:
Taking Safeguard 50mg Tablet and Dinoprostone together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MisoprostolOxytocin
Severe
How does the drug interact with Safeguard 50mg Tablet:
Coadministration of Safeguard 50mg Tablet and Oxytocin can enhance the action of oxytocin. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Safeguard 50mg Tablet and Oxytocin together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden or severe stomach pain, unexplained vaginal bleeding, Fast heart rate or low blood pressure in the pregnant person, diarrhea, or dehydration, consult to a doctor. Do not discontinue any medications without consulting a doctor.
DiclofenacMethotrexate
Severe
How does the drug interact with Safeguard 50mg Tablet:
Co-administration of methotrexate with Safeguard 50mg Tablet can increase the levels and effects of methotrexate. This can lead to increased risk of side effects.

How to manage the interaction:
Although there is a possible interaction between methotrexate and Safeguard 50mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, loss of hunger, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, fits, infection, fever, chills, body aches, sore throat or muscle weakness, consult a doctor immediately. Do not stop using medications without a doctor's advice.
DiclofenacOmacetaxine mepesuccinate
Severe
How does the drug interact with Safeguard 50mg Tablet:
Taking Safeguard 50mg Tablet with Omacetaxine mepesuccinate can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Safeguard 50mg Tablet and Omacetaxine mepesuccinate but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding like dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headaches. Do not discontinue any medications without consulting your doctor.
DiclofenacKetoconazole
Severe
How does the drug interact with Safeguard 50mg Tablet:
Coadministration of Safeguard 50mg Tablet with Ketoconazole may increase the risk of liver problems.

How to manage the interaction:
There may be a possible interaction between Safeguard 50mg Tablet and Ketoconazole, but they can be taken together if a doctor has prescribed them. However, consult a doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DiclofenacKetorolac
Severe
How does the drug interact with Safeguard 50mg Tablet:
Co-administration of Safeguard 50mg Tablet and Ketorolac can increase the risk of side effects.

How to manage the interaction:
Co-administration of Safeguard 50mg Tablet and Ketorolac can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacSirolimus
Severe
How does the drug interact with Safeguard 50mg Tablet:
Co-administration of Safeguard 50mg Tablet with Sirolimus may increase the risk or severity of kidney problems.

How to manage the interaction:
Co-administration of Safeguard 50mg Tablet and Sirolimus can lead to an interaction, but it can be taken if advised by a doctor. However, consult a doctor if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
DiclofenacDeferasirox
Severe
How does the drug interact with Safeguard 50mg Tablet:
Co-administration of Safeguard 50mg Tablet and deferasirox may increase your risk of developing stomach bleeding.

How to manage the interaction:
There may be a possible interaction between Safeguard 50mg Tablet and deferasirox but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms such as severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, increased or decreased urination, fluid retention, swelling, shortness of breath, muscle cramps, weakness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
DiclofenacSulindac
Severe
How does the drug interact with Safeguard 50mg Tablet:
Co-administration of Safeguard 50mg Tablet and sulindac can increase the risk of side effects.

How to manage the interaction:
Although there is a interaction between Safeguard 50mg Tablet and sulindac, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulfate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
  • Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscle strength by lifting light weights.
  • In chronic arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize the level of cytokines, which ramp up inflammation.
  • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel to minimise pain at the back of your curve. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

Habit Forming

No

Therapeutic Class

ANALGESICS

SAFEGUARD 50MG TABLET Substitute

Substitutes safety advice
  • SAFEGUARD TABLET

    by Others

    10.44per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ASPIRIN
  • IBUPROFEN
  • NAPROXEN
  • CELECOXIB
  • INDOMETHACIN
  • MELOXICAM
  • WARFARIN
  • HYDROCHLOROTHIAZIDE
  • LITHIUM

Special Advise

 

Disease/Condition Glossary

Osteoarthritis: Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation, and tenderness. The main reason for osteoarthritis is age. The older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include past injuries such as torn cartilage, dislocated joints, and ligaments.

Rheumatoid arthritis: Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms include pain, swelling, stiffness, deformities, and loss of joint function.

Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain usually starts in the lower back and can spread to the neck, damaged joints, or other parts of the body. Ankylosing spondylitis includes decreased flexibility, which usually leads to hunched-forward posture, pain, and back and joints.

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