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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Safepraz Plus Capsule 10's

Safepraz Plus Capsule 10's is a combination medication used to treat gastro-oesophageal reflux disease (GERD), indigestion, duodenal ulcers, erosive oesophagitis (acid-related damage to the lining of the oesophagus), infections caused by Helicobacter pylori when given along with an antibiotic, and Zollinger-Ellison syndrome. The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, and peptic ulcers.

Safepraz Plus Capsule 10's contains Pantoprazole and Cinitapride. Pantoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of stomach acid. Cinitapride increases the pressure of the inferior oesophageal sphincter, thereby preventing the back-flow of food and acid from the stomach into the mouth. Together, Safepraz Plus Capsule 10's helps in preventing acid reflux, thereby providing relief from acidity and heartburn. 

You are advised to take Safepraz Plus Capsule 10's for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as headache, flatulence, stomach pain, constipation, and diarrhoea. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Safepraz Plus Capsule 10's may cause dizziness, so drive only if you are alert. Safepraz Plus Capsule 10's should not be given to children as safety has not been established. Avoid consuming alcohol along with Safepraz Plus Capsule 10's as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side-effects.

Uses of Safepraz Plus Capsule 10's

Gastro-oesophageal reflux disease (GERD), Zollinger-Ellison disease, Heartburn

Directions for Use

Take Safepraz Plus Capsule 10's 30-60minutes prior food. Swallow Safepraz Plus Capsule 10's as a whole with a glass of water; do not chew, or crush it.

Medicinal Benefits

Safepraz Plus Capsule 10's is a combination medicine used to treat gastro-oesophageal reflux disease (GERD), indigestion, duodenal ulcers, erosive oesophagitis (acid-related damage to the lining of the oesophagus), infections caused by Helicobacter pylori when given along with an antibiotic, and Zollinger-Ellison syndrome. Safepraz Plus Capsule 10's is a combination of two drugs, namely: Pantoprazole and Cinitapride. Pantoprazole is a proton pump inhibitor which works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Cinitapride is a gastro-prokinetic agent which increases the pressure of the inferior oesophageal sphincter, thereby preventing the back-flow of food and acid from the stomach into the mouth. Together, Safepraz Plus Capsule 10's helps in preventing acid reflux, thereby providing relief from acidity. Safepraz Plus Capsule 10's increases gastrointestinal motility by enhancing the strength of contractions without disrupting their rhythm, thereby helps in treating indigestion.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Safepraz Plus Capsule 10's

  • Headache
  • Flatulence
  • Stomach pain
  • Constipation
  • Diarrhoea

Drug Warnings

Do not take Safepraz Plus Capsule 10's if you are allergic to any of its contents. Inform your doctor before taking Safepraz Plus Capsule 10's if you have severe liver or kidney problems; if you are due to have Chromogranin A test. Consult your doctor if you experience unexplained weight loss, stomach pain, indigestion, vomit food or blood, or if you pass black stools. On long-term treatment, Safepraz Plus Capsule 10's may cause osteoporosis, hypomagnesemia (low levels of magnesium), and may reduce the absorption of vitamin B12. Consult your doctor if you are pregnant or breastfeeding. Safepraz Plus Capsule 10's may cause dizziness, so drive only if you are alert. Safepraz Plus Capsule 10's should not be given to children as safety has not been established. Avoid consuming alcohol along with Safepraz Plus Capsule 10's as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side-effects.

Drug-Drug Interactions

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PantoprazoleRilpivirine
Critical
PantoprazoleAtazanavir
Severe

Drug-Drug Interactions

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PantoprazoleRilpivirine
Critical
How does the drug interact with Safepraz Plus Capsule:
Co-administration of Rilpivirine is taken with Safepraz Plus Capsule, can decrease the absorption and blood levels of Rilpivirine and make the medication less effective.

How to manage the interaction:
Taking Safepraz Plus Capsule with Rilpivirine can lead to an interaction, please consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
PantoprazoleAtazanavir
Severe
How does the drug interact with Safepraz Plus Capsule:
Co-administration of Safepraz Plus Capsule reduces stomach acid, decreases the absorption and blood levels of Atazanavir, and reduces its effectiveness.

How to manage the interaction:
Taking Safepraz Plus Capsule with Atazanavir together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
PantoprazoleGefitinib
Severe
How does the drug interact with Safepraz Plus Capsule:
Taking Gefitinib with Safepraz Plus Capsule reduces the acidity level in the stomach and may interfere with the absorption of Gefitinib and reduce its effectiveness.

How to manage the interaction:
Taking Safepraz Plus Capsule with Gefitinib together can possibly result in an interaction, it can be taken if your doctor has advised it. You are recommended to take gefitinib 12 hours before or 12 hours after Safepraz Plus Capsule to help minimize the impact of the interaction. Do not discontinue the medication without consulting a doctor.
PantoprazoleNelfinavir
Severe
How does the drug interact with Safepraz Plus Capsule:
Taking Nelfinavir with Safepraz Plus Capsule may decrease the absorption and blood levels of Nelfinavir and reduce its effectiveness.

How to manage the interaction:
Taking Safepraz Plus Capsule with Nelfinavir together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
PantoprazoleErlotinib
Severe
How does the drug interact with Safepraz Plus Capsule:
Taking Erlotinib with Safepraz Plus Capsule may interfere with the absorption of Erlotinib into the bloodstream, and reduce its effectiveness.

How to manage the interaction:
Taking Safepraz Plus Capsule with Erlotinib together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
PantoprazoleDasatinib
Severe
How does the drug interact with Safepraz Plus Capsule:
Taking Dasatinib with Safepraz Plus Capsule may decrease the blood levels of Dasatinib and reduce its effectiveness.

How to manage the interaction:
Taking Safepraz Plus Capsule with Dasatinib together can result in an interaction, but it can be taken if a doctor has advised it. In case of any unusual side effects, contact a doctor. Do not stop using any medications without a doctor's advice.
PantoprazoleMethotrexate
Severe
How does the drug interact with Safepraz Plus Capsule:
Co-administration of Methotrexate with Safepraz Plus Capsule can increase the levels and side effects of Methotrexate.

How to manage the interaction:
Although there is a possible interaction between Safepraz Plus Capsule and methotrexate, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, or dizziness, consult a doctor. Do not stop using any medications without consulting a doctor.
PantoprazolePazopanib
Severe
How does the drug interact with Safepraz Plus Capsule:
Taking Safepraz Plus Capsule with Pazopanib may reduce the effectiveness of pazopanib.

How to manage the interaction:
If you are supposed to take Safepraz Plus Capsule and Pazopanib together, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PantoprazoleDacomitinib
Severe
How does the drug interact with Safepraz Plus Capsule:
Taking Safepraz Plus Capsule can make Dacomitinib less effective by reducing its absorption in the body.

How to manage the interaction:
Taking Safepraz Plus Capsule with Dacomitinib together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
  • Maintain a healthy weight by regular exercising.
  • Avoid lying down after eating to prevent acid reflux.
  • Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
  • Practise relaxation techniques and avoid stress by doing yoga or meditation.
  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
  • Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes every hour by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

Safepraz Plus Capsule 10's Substitute

Substitutes safety advice
  • Cintodac Capsule 10's

    by Others

    38.88per tablet
  • Eiref-C 40/3 Cap 10'S

    by Others

    35.19per tablet
  • Pantakind Flux Capsule 10's

    by Others

    14.81per tablet
  • Nupenta CP Capsule 10's

    by Others

    24.89per tablet
  • Delpanto CP Capsule 10's

    by Others

    22.50per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ASPIRIN
  • NAPROXEN
  • DULOXETINE
  • LEVOTHYROXINE SODIUM
  • ATORVASTATIN
  • CLOPIDOGREL
  • CYANOCOBALAMIN
  • PHENOTHIAZINE
  • DIGOXIN

Special Advise

  • Inform your doctor before taking Safepraz Plus Capsule 10's if you are due to have Chromogranin A test.
  • Regular monitoring of magnesium and vitamin B12 levels is advised if you are on long-term treatment with Safepraz Plus Capsule 10's.
  • Your doctor may recommend calcium and vitamin supplements if you are on long-term treatment with Safepraz Plus Capsule 10's.

Disease/Condition Glossary

Gastroesophageal reflux disease (GERD): Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing. 

Peptic ulcers: Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of the stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion. 

Indigestion: Indigestion is the feeling of fullness. It occurs due to slow gastric emptying. Symptoms include stomach pain, bloating, heartburn, nausea and vomiting.

Zollinger Ellison syndrome: It is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers.

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