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Written By Sureshvarma D , MPharma
Reviewed By Hari Kumar , MBBS
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Whats That

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Synonym :

CYCLOSPORIN

Composition :

CICLOSPORIN-100MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Sandimmun Neoral 100mg/ml Solution

Sandimmun Neoral 100mg/ml Solution belongs to the class of medicine called 'immunosuppressant' that helps to reduce the pain/inflammation in rheumatoid arthritis conditions and is also used to treat severe psoriasis. Besides this, it also prevents organ rejection after a kidney, heart, or liver transplant. Rheumatoid arthritis is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Psoriasis is a long-lasting, inflammatory skin illness. 

Sandimmun Neoral 100mg/ml Solution contains 'cyclosporine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Sandimmun Neoral 100mg/ml Solution helps stop your body from rejecting a new organ by suppressing your immune system. 

You are advised to take Sandimmun Neoral 100mg/ml Solution for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience headaches, vomiting, nausea, high blood pressure, increased growth of hair, loss of appetite (feeling unwell and upset stomach), kidney disease, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Sandimmun Neoral 100mg/ml Solution for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Before taking Sandimmun Neoral 100mg/ml Solution inform your doctor if you have any allergies, kidney disease, uncontrolled high blood pressure, and any type of cancer. Sandimmun Neoral 100mg/ml Solution should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Uses of Sandimmun Neoral 100mg/ml Solution

Rheumatoid arthritis, Immunosuppressant therapy after organ (liver, kidney, and heart) transplant, and psoriasis (a skin disease that causes itchy and dry patches).

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Solution/Syrup/Suspension/Drops: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Medicinal Benefits

Sandimmun Neoral 100mg/ml Solution belongs to the class of medicine called 'immunosuppressant' that helps to reduce the pain/inflammation in rheumatoid arthritis conditions and is also used to treat severe psoriasis. Besides this, it also prevents organ rejection after a kidney, heart, or liver transplant. Sandimmun Neoral 100mg/ml Solution contains 'cyclosporine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Sandimmun Neoral 100mg/ml Solution helps stop your body from rejecting a new organ by suppressing your immune system. 

Storage

Store in a cool and dry place away from sunlight
Side effects of Sandimmun Neoral 100mg/ml Solution 50 ml
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Increase protein intake by eating protein-rich foods like eggs, fish, lean meat, beans, and nuts to support nail strength.
  • Include biotin-rich foods like salmon, avocado, bananas, almonds, and whole grains in your diet to promote nail health.
  • Boost iron intake by consuming iron-rich foods like spinach, red meat, lentils, and fortified cereals to prevent iron deficiency.
  • Moisturize your nails and cuticles regularly by applying cuticle oil or hand cream multiple times a day.
  • Keep your nails short to reduce the risk of breakage and snagging.
  • Avoid biting your nails, as it can cause significant damage to your nails and cuticles.
  • Consider taking biotin supplements after consulting your doctor, as they may help strengthen brittle nails.

Drug Warnings

Do not take Sandimmun Neoral 100mg/ml Solution if you are allergic to any immunosuppressant medicines or Cyclosporine. Let your doctor know if you have liver or kidney problems, high blood pressure, low levels of magnesium, and high levels of potassium. Sandimmun Neoral 100mg/ml Solution may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Before taking Sandimmun Neoral 100mg/ml Solution inform your doctor if you have any type of cancer. Sandimmun Neoral 100mg/ml Solution should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Sandimmun Neoral 100mg/ml Solution 50 ml:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Sandimmun Neoral 100mg/ml Solution 50 ml with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
How does the drug interact with Sandimmun Neoral 100mg/ml Solution 50 ml:
Coadministration of pitavastatin with Sandimmun Neoral 100mg/ml Solution 50 ml may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Sandimmun Neoral 100mg/ml Solution 50 ml is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Sandimmun Neoral 100mg/ml Solution 50 ml:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Sandimmun Neoral 100mg/ml Solution 50 ml with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Sandimmun Neoral 100mg/ml Solution 50 ml:
Combining Sandimmun Neoral 100mg/ml Solution 50 ml and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Sandimmun Neoral 100mg/ml Solution 50 ml and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Sandimmun Neoral 100mg/ml Solution 50 ml:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Sandimmun Neoral 100mg/ml Solution 50 ml with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Sandimmun Neoral 100mg/ml Solution 50 ml:
When etanercept is taken with cyclosporine, it can increase the risk of infections.

How to manage the interaction:
Although taking etanercept and Sandimmun Neoral 100mg/ml Solution 50 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, contact a doctor immediately if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
CiclosporinVenetoclax
Severe
How does the drug interact with Sandimmun Neoral 100mg/ml Solution 50 ml:
Co-administration of venetoclax with Sandimmun Neoral 100mg/ml Solution 50 ml may significantly increase the blood levels and effects of venetoclax.

How to manage the interaction:
Although there is a possible interaction between venetoclax and Sandimmun Neoral 100mg/ml Solution 50 ml, they can be taken together if your doctor has prescribed them. However, contact your doctor immediately if experience any symptoms such as nausea, paleness, vomiting, diarrhea and weakness. Do not stop using any medications without talking to a doctor.
How does the drug interact with Sandimmun Neoral 100mg/ml Solution 50 ml:
The combined use of aliskiren and Sandimmun Neoral 100mg/ml Solution 50 ml can significantly increase the blood levels and effects of aliskiren, which may lead to low blood pressure, hyperkalemia (high potassium levels) in the body. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythms. If you are elderly, dehydrated, or have kidney disease, diabetes, or severe heart failure, you are more prone to develop hyperkalemia while taking these medications.

How to manage the interaction:
Taking aliskiren and Sandimmun Neoral 100mg/ml Solution 50 ml will lead to an interaction, they can be taken together if your doctor has prescribed them. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. It is advised to reduce intake of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes.
How does the drug interact with Sandimmun Neoral 100mg/ml Solution 50 ml:
Using atazanavir with ciclosporine may increase the blood levels and effects of Sandimmun Neoral 100mg/ml Solution 50 ml

How to manage the interaction:
Although there is a interaction between Sandimmun Neoral 100mg/ml Solution 50 ml and atazanavir, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, dizziness, weakness, headache, shaking, fits, fever, sore throat, unusual bruising or bleeding, and increased or decreased urination. Do not discontinue any medications without consulting a doctor.
CiclosporinEdoxaban
Severe
How does the drug interact with Sandimmun Neoral 100mg/ml Solution 50 ml:
Taking edoxaban and Sandimmun Neoral 100mg/ml Solution 50 ml can significantly increase the blood levels of edoxaban.

How to manage the interaction:
Taking Sandimmun Neoral 100mg/ml Solution 50 ml with edoxaban together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience bleeding, bruising, blood in stools or urine, dizziness, severe headache, weakness, or vomiting contact a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Acupuncture, massage, and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Sandimmun Neoral 100mg/ml Solution acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby providing relief from rheumatoid arthritis.

If you miss a dose of Sandimmun Neoral 100mg/ml Solution, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the scheduled dose. Do not take a double dose to make up for a missed one.

Diarrhoea might be a side-effect of Sandimmun Neoral 100mg/ml Solution. Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excess diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

Yes, using Sandimmun Neoral 100mg/ml Solution may cause abnormal hair growth, although it does not affect everybody. Consult your doctor if you have any concerns.

Sandimmun Neoral 100mg/ml Solution is known to decrease the immune system. As a result, it increases your risk of developing cancers, especially of the skin. You should reduce your contact with sunlight and UV light by wearing suitable protective clothing. Sunscreen should be used regularly.

Drug-Drug Interactions Checker List

  • TACROLIMUS
  • AMILORIDE
  • SPIRONOLACTONE
  • ALISKIREN
  • ATORVASTATIN
  • PITAVASTATIN
  • SIMVASTATIN
  • ERYTHROMYCIN
  • AZITHROMYCIN
  • VORICONAZOLE
  • ITRACONAZOLE
  • DILTIAZEM
  • VERAPAMIL
  • DANAZOL
  • ALLOPURINOL
  • COLCHICINE
  • TELAPREVIR

Special Advise

  • Use sunscreen while taking Sandimmun Neoral 100mg/ml Solution, as it can make your skin more sensitive to sunlight and may cause skin cancer.
  • Long-term use of Sandimmun Neoral 100mg/ml Solution may increase your risk of developing cancers like blood cancer, skin cancer, and immune system cancer (lymphoma). 

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Organ (kidney, heart, or liver) transplant rejection: When you get a new organ transplanted into your body, your body recognizes it as a foreign element and tries to attack and reject it because it is not originally part of your body. So, immunosuppressant drugs like cyclosporine are given to such patients to suppress their immune system to prevent an attack on a newly transplanted organ. The goal is to adjust immunosuppressants to prevent rejection and minimize any side effects of the drugs.

Psoriasis: It is a long-lasting, inflammatory skin illness. It is not infectious but has a tendency to run in families. It causes itchy and red patches on the skin.

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