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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
COD available

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Whats That

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Composition :

ETODOLAC-300MG

Manufacturer/Marketer :

Zuventus Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Setolac 300 ER Tablet

Setolac 300 ER Tablet belongs to the group of pain killers known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to treat mild to moderate pain in osteoarthritis and rheumatoid arthritis. Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering (cartilage). Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage.

 

Setolac 300 ER Tablet works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

 

Take Setolac 300 ER Tablet with or after food. You are advised to take Setolac 300 ER Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as stomach pain, diarrhoea, indigestion, headache, loss of appetite, nausea and vomiting. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you should talk to your doctor if you experience these side-effects persistently.

 

Consult your doctor before taking Setolac 300 ER Tablet if you are pregnant or breastfeeding; your doctor will prescribe Setolac 300 ER Tablet only if the benefits outweigh the risks. Setolac 300 ER Tablet may cause drowsiness and dizziness, so drive with caution. Setolac 300 ER Tablet is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Setolac 300 ER Tablet as it could lead to increased drowsiness and dizziness. It could also increase the risk of stomach bleeding.

Uses of Setolac 300 ER Tablet

Osteoarthritis, Rheumatoid arthritis

Directions for Use

Take Setolac 300 ER Tablet with or after food. Swallow it as a whole with a glass of water. Do not crush, chew or break the tablet/capsule. Based on your medical condition, your doctor will advise for how long you need to take Setolac 300 ER Tablet .

Medicinal Benefits

Setolac 300 ER Tablet works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Thus, Setolac 300 ER Tablet helps treat pain associated with osteoarthritis and rheumatoid arthritis.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Setolac 300 ER Tablet can increase your risk of fatal heart attack or stroke. So, if you have had any recent heart bypass surgery, do not use Setolac 300 ER Tablet . Do not take Setolac 300 ER Tablet if you are allergic to Etodolac, have severe heart failure or peptic ulcer, have suffered bleeding problems such as bleeding from stomach or bowels while taking any pain killers or you have liver or kidney problems. Inform your doctor before taking Setolac 300 ER Tablet if you are taking medicines for high blood pressure and fluid retention. Consult your doctor before taking Setolac 300 ER Tablet if you are pregnant or breast-feeding, your doctor will prescribe you Setolac 300 ER Tablet only if the benefits outweigh the risks. Setolac 300 ER Tablet causes drowsiness and dizziness, so drive only if you are alert. Setolac 300 ER Tablet should not be given to children as the safety has not been established. Avoid consuming alcohol along with Setolac 300 ER Tablet as it could lead to increased drowsiness and can increase the risk of stomach bleeding. Inform your doctor before taking Setolac 300 ER Tablet if you suffer from fluid retention (swelling), high blood pressure, heart problems, asthma or breathing difficulties. Use of Setolac 300 ER Tablet can make your skin very sensitive to sunlight which can even cause sunburn. So, whenever you step out of home try to apply sunscreen on your skin.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Setolac 300 ER Tablet:
Co-administration of Setolac 300 ER Tablet with Meloxicam can raise the adverse consequences in the digestive system, including inflammation, bleeding, ulceration, and, in rare cases, perforation(rupture).

How to manage the interaction:
Taking Meloxicam with Setolac 300 ER Tablet is not recommended can result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Setolac 300 ER Tablet:
Using ketorolac together with Setolac 300 ER Tablet may increase the risk of side effects in the gastrointestinal tract (inflammation, bleeding and ulceration).

How to manage the interaction:
Taking Setolac 300 ER Tablet with Ketorolac is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Setolac 300 ER Tablet:
Co-administration of Setolac 300 ER Tablet with Prasugrel can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Although taking Setolac 300 ER Tablet and Prasugrel together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Setolac 300 ER Tablet:
Co-administration of Setolac 300 ER Tablet and Rivaroxaban can increase the risk of bleeding problems, including severe hemorrhage.

How to manage the interaction:
Co-administration of Setolac 300 ER Tablet and Rivaroxaban can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Setolac 300 ER Tablet:
The use of acalabrutinib in conjunction with Setolac 300 ER Tablet may raise the risk of bleeding. Treatment with acalabrutinib alone has been linked to severe haemorrhage.

How to manage the interaction:
Taking Setolac 300 ER Tablet with Acalabrutinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, a severe headache, and/or weakness, consult your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Setolac 300 ER Tablet:
Taking Indomethacin with Setolac 300 ER Tablet can increase the risk of side effects (inflammation, bleeding, ulceration, and perforation of the stomach).

How to manage the interaction:
Although there is a possible interaction between Setolac 300 ER Tablet and Indomethacin, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Setolac 300 ER Tablet:
When Setolac 300 ER Tablet is taken with Dabigatran etexilate may increase the risk or severity of bleeding and hemorrhage.

How to manage the interaction:
Taking Dabigatran etexilate with Setolac 300 ER Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you happen to have any unusual bleeding or bruising, or other signs and symptoms of bleeding, such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Setolac 300 ER Tablet:
Co-administration of methotrexate with Setolac 300 ER Tablet can increase the level and effects of methotrexate. This can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between methotrexate and Setolac 300 ER Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
EtodolacDicoumarol
Severe
How does the drug interact with Setolac 300 ER Tablet:
Taking Setolac 300 ER Tablet with dicumarol may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Setolac 300 ER Tablet and Dicoumarol, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Setolac 300 ER Tablet:
When tolmetin is used with Setolac 300 ER Tablet, there is an increased risk of significant gastrointestinal toxicity (inflammation, bleeding, ulceration, and perforation).

How to manage the interaction:
Taking Setolac 300 ER Tablet with Tolmetin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

Habit Forming

No

Therapeutic Class

ANALGESICS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Setolac 300 ER Tablet works by blocking the effect of chemical messengers (prostaglandin), thereby helping in reducing joint pain, stiffness, swelling and inflammation.

Diarrhoea might be a side-effect of Setolac 300 ER Tablet . Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience excess diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

Setolac 300 ER Tablet might cause stomach-upset, abdominal pain and indigestion. To prevent this take Setolac 300 ER Tablet with or after food.

Do not take Setolac 300 ER Tablet for longer durations or high doses as it may cause heart attack or stroke. Do not exceed the dose and duration prescribed by your doctor.

Do not overdose on Setolac 300 ER Tablet or any medicine as it could lead to unpleasant side-effects. Take Setolac 300 ER Tablet only as prescribed by your doctor. Rush to your nearest doctor as early as possible if you have overdosed on Setolac 300 ER Tablet . Symptoms of overdose include nausea, vomiting, stomach pain, headache, blood in stools/faeces.

Yes, Setolac 300 ER Tablet might affect certain test results like blood or urine tests. Inform your doctor that you are taking Setolac 300 ER Tablet before undergoing any tests.

Yes, the use of Setolac 300 ER Tablet can make the skin very sensitive to sunlight which can even cause sunburn. So, whenever you step out of home try to apply sunscreen on your skin.

Setolac 300 ER Tablet can increase your risk of a fatal heart attack or stroke. If you have any recent heart bypass surgery, do not use Setolac 300 ER Tablet .

Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ASPIRIN
  • DICLOFENAC
  • DULOXETINE
  • ESCITALOPRAM
  • METOPROLOL
  • WARFARIN
  • DIGOXIN
  • LITHIUM
  • CYCLOSPORINE
  • MIFEPRISTONE

Special Advise

Setolac 300 ER Tablet should be taken with caution in patients with gastric problems like gastritis and peptic ulcers. Please consult your doctor if you have any concerns regarding this.

Disease/Condition Glossary

Osteoarthritis: It is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation and tenderness. The main reason for osteoarthritis is age, the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include a past injury such as torn cartilage, dislocated joints and ligament injuries.

Rheumatoid arthritis: It is an auto-immune disease (the body’s immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function.

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