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  3. SIBOLONE TABLET

SIBOLONE TABLET, Pack of 15 TABLETS
SIBOLONE TABLET, Pack of 15 TABLETS
SIBOLONE TABLET, Pack of 15 TABLETS
Written By Veda Maddala , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
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Whats That

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Composition :

TIBOLONE-2.5MG

Manufacturer/Marketer :

Serum Institute Of India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About SIBOLONE TABLET

SIBOLONE TABLET belongs to the class of medicines called synthetic steroids used to treat postmenopausal symptoms and prevent osteoporosis (weak and brittle bones) caused in menopausal women. SIBOLONE TABLET is a hormone replacement therapy (HRT). Postmenopause is a condition in which women have not had a period of 12 months or longer. The oestrogen levels decrease in postmenopausal women resulting in symptoms such as hot flushes (hot neck, face and chest). Osteoporosis is a bone disease that weakens and thins bones by decreasing bone density which is common in post-menopausal women.

SIBOLONE TABLET contains Tibolone which works by mimicking the activity of natural hormones progesterone, oestrogen and testosterone. Thereby, it reduces menopausal symptoms by restoring hormone levels in the body. Also, SIBOLONE TABLET prevents osteoporosis in postmenopausal women by restoring oestrogen levels in the body and preventing bone loss and fractures.

Take SIBOLONE TABLET as prescribed by your doctor. You are advised to take SIBOLONE TABLET for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, breast pain, vaginal bleeding or spotting, unusual hair growth, weight gain, vaginal itching or irritation. Most of these side effects of SIBOLONE TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to SIBOLONE TABLET or any other medicines, please tell your doctor. Avoid taking SIBOLONE TABLET if you are pregnant or breastfeeding and consult a doctor. SIBOLONE TABLET is not recommended for children. You are recommended to avoid alcohol consumption with SIBOLONE TABLET as it may increase the risk of breast cancer. If you have premature menopause, inform your doctor before taking SIBOLONE TABLET so that the risks and benefits may be compared.

Uses of SIBOLONE TABLET

Postmenopausal symptoms and prevent osteoporosis in a postmenopausal woman

Directions for Use

Take SIBOLONE TABLET with or without food as prescribed by your doctor. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Medicinal Benefits

SIBOLONE TABLET contains Tibolone, a hormone replacement therapy (HRT) used to treat postmenopausal symptoms and prevent osteoporosis (weak and brittle bones) caused by menopause in women. SIBOLONE TABLET mimics the activity of natural hormones progesterone, estrogen, and testosterone. Thereby restoring hormone levels in the body and reducing menopausal symptoms. Also, SIBOLONE TABLET prevents osteoporosis in postmenopausal women and prevents bone loss and fractures. The risk of breast cancer and blood clots is less with SIBOLONE TABLET than with other HRT.

Storage

Store in a cool and dry place away from sunlight
Side effects of Sibolone Tablet
  • You can take your medicine with meals to lower the chances of getting stomach pain.
  • Avoid foods that are acidic, spicy, sugary, or greasy.
  • Eat foods that are easily digestible such as rice, toast, and bananas.
  • Eat your meals in smaller amounts throughout the day to prevent strain on your stomach and digestion.
  • Drink water or fluids to stay hydrated and prevent stomach upset.
  • Use a heating pad or massage your stomach area.
  • Engage in mild physical activities such as yoga and walking.
  • Eat lean protein sources like chicken, tofu, and other low-fat protein sources.
  • Include whole grains like brown rice, quinoa, and whole-wheat bread.
  • Eat plenty of fruits and vegetables.
  • Avoid processed foods and limit or avoid packaged options.
  • Limit sugary drinks and avoid soda and other sugary beverages.
  • Maintain a balanced diet ensuring enough calories, protein, and micronutrients.
  • Address nutritional deficiencies by considering supplements or consulting a doctor.
  • Recognize that hair growth is complex and nutritional deficiencies may impact hair structure and growth.
  • Achieve and maintain a healthy weight through a balanced diet and regular physical activity to minimize the risk of heavy bleeding.
  • Consume a diet rich in whole, nutrient-dense foods, including fruits, vegetables, and whole grains, to help stabilize hormonal balances and reduce inflammation.
  • Incorporate foods high in omega-3 fatty acids, such as fatty fish and flaxseeds, into your diet to help mitigate inflammation and promote the healing process.
  • Restrict or avoid consumption of foods that may worsen bleeding, such as spicy or acidic foods, to help reduce discomfort and promote recovery.
  • Prioritize getting adequate sleep, aiming for 7-8 hours per night, to help regulate hormonal balances and reduce the risk of bleeding.
  • Consider taking supplements, such as iron or vitamin B12, under the guidance of a healthcare provider, to help manage anemia and support the healing process.
  • Consult a doctor if bleeding persist or worsen.
  • Ensure the genital area is as dry as possible after bathing or showering.
  • Do not scratch as this may worsen the irritation and itching.
  • Gently wash the genital area with mild soap and warm water to keep it clean.
  • Wear loose, airy clothes to avoid skin irritation and aggravation of the itch.
  • Scented toilet paper should be avoided to prevent irritation.
  • If you develop severe or chronic genital itching, see your doctor because it can be an infection, a disease, or possibly both.
  • Eat a balanced diet rich in fruits, vegetables, and whole grains to support overall health.
  • Incorporate probiotic-rich foods like yogurt or kefir into your diet to promote gut health.
  • Practice good genital hygiene by washing with warm water and avoiding harsh soaps.
  • Wear loose, breathable cotton underwear to reduce moisture buildup.
  • Avoid douching and scented soaps that can disrupt natural vaginal balance.
  • Stay dry and change out of wet clothes promptly to prevent yeast growth.
  • Limit excessive sugar consumption to reduce yeast growth.
  • Consider adding antifungal foods like garlic or turmeric to your diet.
  • Reduce stress levels by practicing calming techniques such as mindfulness, meditation, or controlled breathing exercises.
  • Complete the full course of prescribed antifungal treatment to prevent recurrence.
  • Consult your doctor if you experience frequent or severe yeast infections.
  • Vaginal bleeding can be abnormal if it is not related to menstruation, and needs immediate attention and cannot be ignored.
  • Get a physical examination and follow your doctor's instructions to get relief from bleeding.
  • Avoid using vaginal sprays or perfumed soaps that increase itching and irritation.
  • Prefer practicing yoga and meditation to reduce stress and anxiety, as it can worsen vaginal bleeding.
  • Take a balanced diet and manage your weight.
  • Talk to your doctor to know the cause, severity and appropriate treatment options.
  • Try pain relievers like ibuprofen or naproxen to relieve mild pelvic pain.
  • Consider pelvic floor exercises as it helps to strengthen muscles in the pelvic region and relieve pain.
  • Try relaxation techniques like deep breathing, meditation or gentle stretching.

Drug Warnings

If you are allergic to SIBOLONE TABLET or any other medicines, please tell your doctor. Avoid taking SIBOLONE TABLET if you are pregnant or breastfeeding and consult a doctor. SIBOLONE TABLET is not recommended for children. If you have premature menopause, inform your doctor before taking SIBOLONE TABLET so that the risks and benefits may be compared. Avoid taking SIBOLONE TABLET if you have recently had a stroke, heart attack, or angina (chest pain).  If you have very high levels of fat (triglycerides) in blood, inform your doctor before taking SIBOLONE TABLET. You are recommended to avoid alcohol consumption with SIBOLONE TABLET as it may increase the risk of breast cancer. If you experience sudden chest pain, difficulty in breathing, or painful swelling and redness of your legs, stop taking SIBOLONE TABLET and consult a doctor immediately as these might be signs of a blood clot.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include dairy products like milk, yogurt, cheese, or milk-based custard in your diet.
  • Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
  • Snack on calcium-rich nuts like Brazil nuts or almonds.
  • Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
  • Avoid or reduce the intake of caffeine, soft drinks, and alcohol that inhibit calcium absorption.
  • Replace the meat with tofu or tempeh for extra calcium in your food.

Habit Forming

No

Therapeutic Class

SYNTHETIC ANABOLIC STEROID

SIBOLONE TABLET Substitute

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Hari Kumar

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:38 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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FAQs

SIBOLONE TABLET contains Tibolone that works by mimicking the activity of natural hormones progesterone, oestrogen and testosterone. Thereby, restores hormone levels in the body and reduces menopausal symptoms and prevents osteoporosis (weak and thin bones) in postmenopausal women.

SIBOLONE TABLET may cause irregular bleeding or spotting (drops of blood) during the first 3 to 6 months of taking SIBOLONE TABLET. However, if the bleeding or spotting continues for more than 6 months or after discontinuing SIBOLONE TABLET, please consult a doctor immediately.

You may be advised to stop taking SIBOLONE TABLET about 4 to 6 weeks before surgery to decrease the risk of a blood clot. Therefore, inform your doctor that you are taking SIBOLONE TABLET before undergoing any surgery.

SIBOLONE TABLET may increase the risk of endometrial (lining of the womb) cancer especially if it is taken for a prolonged duration. Also, SIBOLONE TABLET may increase cell growth resulting in excessive thickening of the womb lining (endometrial hyperplasia).

SIBOLONE TABLET is not a contraceptive. SIBOLONE TABLET is a hormone replacement therapy. Therefore, if you are less than 50 years old or if it is less than 12 months since your last period, you are advised to use additional contraceptive measures to avoid pregnancy. However, discuss with a doctor if you have any concerns regarding this.

Drug-Drug Interactions Checker List

  • WARFARIN
  • PHENYTOIN
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • RIFAMPICIN

Special Advise

  • Regular breast screening is recommended while taking SIBOLONE TABLET.
  • Check your breasts regularly for any changes in the nipple, dimpling of the skin or any lumps. 

Disease/Condition Glossary

Hormone replacement therapy (HRT): It is a treatment to relieve menopause symptoms. It replaces hormones that are at a lower level as you approach menopause.

Osteoporosis: It is a bone disease that weakens and thins bones by decreasing bone density. As the density of bones decreases, they weaken and are more likely to break. Post-menopausal women are more likely to develop osteoporosis than men because, at menopause, a woman’s ovaries stop producing estrogen (a female hormone) which is essential to keep bones healthy. Following menopause, bone loss occurs, making bones weak and more likely to break. Also, long-term use of steroids may affect bone strength and cause osteoporosis in both men and women. Signs and symptoms include back pain caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, and a bone that breaks much more easily than expected.

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