Simenda 12.5mg Injection 5 ml belongs to the group of medications called 'calcium sensitizer' primarily used to treat hospitalized patients with acute heart failure. Heart failure can occur when your heart cannot pump blood sufficiently required to the remainder of the body. A heart attack is the blockage of blood flow to the heart muscle. The blockage is most often a build-up of fat, cholesterol, and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).  Heart attack and brain stroke can occur simultaneously as the brain's stroke blood supply gets interrupted, causing a part of the brain to die.

Simenda 12.5mg Injection 5 ml contains 'levosimendan', which works by increasing the heart's sensitivity to calcium ion (Ca) without increasing the amount of calcium present in the heart's muscles cells. Simenda 12.5mg Injection 5 ml widens up the heart's blood vessels (coronary artery) and, in turn, relaxes the smooth muscles of the heart so that blood and oxygen can flow easily to the whole body. 

The most common side effects of Simenda 12.5mg Injection 5 ml are headache, low blood pressure, and nausea (stomach discomfort). Most of these side effects of Simenda 12.5mg Injection 5 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Simenda 12.5mg Injection 5 ml should not be given to the patients with low blood pressure (hypotension), dehydration, low blood count, chest pain (angina), or have abnormal heart rhythm. Pregnant or lactating women should consult a doctor before administration of Simenda 12.5mg Injection 5 ml. This medicine should not be given to children and adolescents under 18 years of age. 

Simenda 12.5mg Injection 5 ml is a calcium sensitizer that enhances the heart's pumping forces and allows blood vessels to relax. Improvement of the cardiac function by Simenda 12.5mg Injection 5 ml helps reduce the congestion in your lungs and enhances blood and oxygen delivery to the organs. Thus, treatment with Simenda 12.5mg Injection 5 ml relieves the shortness of breath from severe heart failure.

• Headache
• Low blood pressure (hypotension)
• Nausea (feeling sick)
• Tachycardia (fast heartbeat)

Do not use Simenda 12.5mg Injection 5 ml if you are allergic to any of its contents. Do not take Simenda 12.5mg Injection 5 ml if you are pregnant, think you may be pregnant, or trying for pregnancy. Consult your doctor before taking Simenda 12.5mg Injection 5 ml if you are breastfeeding. Try not to stop taking this medicine of your own as stopping Simenda 12.5mg Injection 5 ml abruptly may worsen your condition and increase your risk of a future heart attack. Simenda 12.5mg Injection 5 ml should not be given to the patients with low blood pressure (hypotension), dehydration, low blood count, chest pain (angina), or have abnormal heart rhythm. This medicine should not be given to children and adolescents under 18 years of age. Simenda 12.5mg Injection 5 ml should not be given into the same vein as other medicines except for heart-related medicines like frusemide, digoxin or glyceryl trinitrate. This is because if you have been given other heart-related medicines through your veins, your blood pressure might drop if you are given Simenda 12.5mg Injection 5 ml. 

Drug-Drug Interactions: Simenda 12.5mg Injection 5 ml may have interaction with medications used to treat high blood pressure like Atenolol, drugs used to treat attention deficit hyperactivity disorder like Atomoxetine. This is not a complete list of all the possible drug interactions.

Drug-Food Interactions: Avoid consuming grapefruit and grapefruit juice with Simenda 12.5mg Injection 5 ml. Do not take St. John’s wort (herbal supplement to treat depression) with Simenda 12.5mg Injection 5 ml. 

Drug-Disease Interaction: Simenda 12.5mg Injection 5 ml may have interactions with disease conditions such as rhabdomyolysis (muscle breakdown), Reye’s syndrome, asthma, gout, glaucoma, liver disease, diabetes, and cognitive impairment.

• ATENOLOL
• ATOMOXETINE

• Follow a cholesterol-lowering diet.
• Consume a low-salt and a low-fat diet.
• Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
• Limit salt and sugar intake.
• Avoid smoking and alcohol consumption. 
• Choose healthy fats and cut down on trans-fat.
• Include omega-3 fatty acids, fibre-rich food, fruits, and vegetables.
• Get active by doing any physical activity such as swimming, brisk walking, or jogging. Take the stairs instead of elevators/lifts.

• Simenda 12.5mg Injection 5 ml is for in-hospital use only. Hence it should be administered in a hospital setting where adequate monitoring facilities and expertise with inotropic agents are available.
• The effect on your heart of Simenda 12.5mg Injection 5 ml will last for at least 24 hours after the Simenda 12.5mg Injection 5 ml infusion is stopped. This effect may continue for 7-9 days after the infusion is stopped. 
• It is advisable to have complete cholesterol tests (lipid profile test) at least once a year. It will help you to closely monitor your heart health and risk of heart attack and stroke. 
• Regularly monitor blood pressure levels, heart rate and electrolyte levels.
• Your doctor will measure how you respond to Simenda 12.5mg Injection 5 ml by measuring your heart rate, blood pressure, ECG, and how you are feeling. 

Heart failure: It happens, the heart becomes unable to pump blood in the whole body as it should. Certain conditions like high blood pressure can put the heart at risk of heart failure.

Heart attack: Heart attack or stroke occurs due to the blockage of blood flow to the heart muscle. The blockade usually occurs due to the build-up of fat/cholesterol in the coronary artery. High cholesterol levels might lead to a build-up of fat on the arteries' walls, leading to blockage of blood flow to the heart and other body parts, which could cause heart diseases, heart attack, or stroke. Cholesterol is mainly of two types, namely bad cholesterol and good cholesterol. Bad cholesterol comprises low-density lipoprotein (LDL) and triglycerides (TG) which deposits fat in the arteries leading to their blockage. Good cholesterol consists of high-density lipoprotein (HDL), which prevents the deposition of fats. Angina symptoms include pain or tightness in the chest, discomfort, pain in the neck, arms, or back, weakness, lightheadedness, and abnormal heartbeat. Risk factors include obesity, stress, smoking, a high-fat diet, lack of exercise and genetics.