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  3. Sirotem Injection

Sirotem Injection, Pack of 1 Injection
Sirotem Injection, Pack of 1 Injection
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Composition :

TEMSIROLIMUS-25MG/ML

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Sirotem Injection

Sirotem Injection belongs to the group of anti-cancer medicines called kinase inhibitors used to treat advanced renal cell carcinoma (a type of cancer that begins in the kidney). It may also be used for previously treated mantle cell lymphoma (a type of cancer affecting the lymph nodes).
 
Sirotem Injection contains Temsirolimus, which works by blocking the action of abnormal proteins needed for cancer cells to multiply. This helps slow the growth of tumours. Thereby, it helps treat kidney cancer.
 
In some cases, Sirotem Injection may cause side effects such as diarrhoea, nausea, vomiting, constipation, headache, fever, and decreased appetite. Most of these side effects may not require medical attention and resolve over time. Do not be reluctant to talk with your doctor if any of these side effects persist or worsen.
 
Consult the doctor if you are pregnant or breastfeeding. Sirotem Injection is not recommended for children below 18 years as the effectiveness has not been established. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Sirotem Injection

 Renal cell cancer (Kidney cancer).

Directions for Use

Sirotem Injection will be administered by a healthcare professional who is trained and experienced in the administration of anticancer medicine; do not self-administer.

Medicinal Benefits

Sirotem Injection belongs to the group of anti-cancer medicines called kinase inhibitors used to treat advanced renal cell carcinoma (a type of cancer that begins in the kidney). It may also be used for previously treated mantle cell lymphoma (a type of cancer affecting the lymph nodes). Sirotem Injection contains Temsirolimus, a selective inhibitor of the enzyme mTOR (mammalian target of rapamycin) that blocks tumour cell growth and division. Thereby, it helps treat kidney cancer.

Storage

Store in a cool and dry place away from sunlight
Side effects of Sirotem Injection
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

Drug Warnings

Do not use Sirotem Injection if you are allergic to any of its components if you are allergic to sirolimus (immunosuppressant), or if you have mantle cell lymphoma or liver problems. Inform the doctor if you are allergic to or cannot use anti-histamines if you have/had a tumour in the brain or spinal cord, bruising/bleeding problems, infections, inflammation of lungs, liver or kidney problems, high cholesterol levels, diabetes, eye problems, if you are taking anticoagulants if you drink alcohol or are alcoholic if you are due to undergo any vaccination or surgery, or if you are over 65 years of age. Consult the doctor if you are pregnant or breastfeeding. Sirotem Injection is not recommended for children below 18 years as the effectiveness has not been established.

Drug-Drug Interactions

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TemsirolimusPiroxicam
Severe
TemsirolimusEtodolac
Severe

Drug-Drug Interactions

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TemsirolimusPiroxicam
Severe
How does the drug interact with Sirotem Injection:
Taking Piroxicam with Sirotem Injection may increase the risk of kidney damage.

How to manage the interaction:
Taking Piroxicam with Sirotem Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without consulting a doctor.
TemsirolimusEtodolac
Severe
How does the drug interact with Sirotem Injection:
Taking Etodolac and Sirotem Injection can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Etodolac and Sirotem Injection, you can take these medicines together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Temsirolimusvalacyclovir
Severe
How does the drug interact with Sirotem Injection:
Co-administration of Sirotem Injection with valacyclovir may increase the risk of kidney problems.

How to manage the interaction:
Although taking Sirotem Injection and valacyclovir together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased urination, weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without consulting a doctor.
TemsirolimusFosphenytoin
Severe
How does the drug interact with Sirotem Injection:
When Sirotem Injection is taken with Fosphenytoin, it can cause Sirotem Injection to be broken down faster in the body. This can lead to low treatment outcomes

How to manage the interaction:
Although taking Fosphenytoin and Sirotem Injection together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any unusual symptoms or if your condition worsens, make sure to contact your doctor right away. Do not stop using any medications without talking to your doctor.
TemsirolimusInfliximab
Severe
How does the drug interact with Sirotem Injection:
When Sirotem Injection is taken with Infliximab, it can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Infliximab and Sirotem Injection, you can take these medicines together if prescribed by your doctor. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TemsirolimusVoriconazole
Severe
How does the drug interact with Sirotem Injection:
Using Sirotem Injection together with Voriconazole may significantly increase the blood levels and effects of Sirotem Injection.

How to manage the interaction:
Although taking Voriconazole and Sirotem Injection together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
TemsirolimusEzetimibe
Severe
How does the drug interact with Sirotem Injection:
Taking Sirotem Injection and Ezetimibe can increase blood levels of cholesterol and triglycerides.

How to manage the interaction:
There may be a possibility of interaction between Ezetimibe and Sirotem Injection, but it can be taken if prescribed by a doctor. If you are taking sirolimus or Sirotem Injection along with your cholesterol-lowering medications, it is important to regularly check blood cholesterol and triglyceride levels with a doctor. Do not discontinue any medications without consulting a doctor.
TemsirolimusGentamicin
Severe
How does the drug interact with Sirotem Injection:
Co-administration of Gentamicin and Sirotem Injection may increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Gentamicin with Sirotem Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on how much you pee. If you notice any changes like peeing more or less than usual, it's a good idea to let your doctor know right away. Some signs to watch out for include gaining weight quickly, feeling bloated, having trouble breathing, or feeling sick to your stomach. Other symptoms to be aware of are not feeling hungry, losing weight, swelling, muscle cramps, feeling weak or dizzy, feeling confused, or having an irregular heartbeat. Do not stop using any medications without a doctor's advice.
TemsirolimusCladribine
Severe
How does the drug interact with Sirotem Injection:
Combining Cladribine with Sirotem Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladribine and Sirotem Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
TemsirolimusVancomycin
Severe
How does the drug interact with Sirotem Injection:
Coadministration of Vancomycin with Sirotem Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Vancomycin with Sirotem Injection may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables, whole grains and fruits in your diet.
  • Avoid fast, fried foods, processed meats, highly processed foods and beverages, and salty snacks.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Sirotem Injection Substitute

Substitutes safety advice

  • Genxtor Injection

    by Others

    ₹41000.00per tablet

Product Substitutes

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 20, 2024 | 1:18 PM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Sirotem Injection works by blocking tumour cell growth and division. Thereby, it helps treat kidney cancer.

Sirotem Injection may result in immunosuppression, leading to an increased risk of infections. Wash your hands frequently and avoid contact with sick people.

Vaccination may be less effective if taken during treatment with Sirotem Injection. Also, some vaccinations should be avoided during treatment. Therefore, do not have any vaccinations without consulting the doctor.

Fertility may be compromised during treatment with Sirotem Injection. Consult the doctor if you have any concerns.

Drug-Drug Interactions Checker List

  • RIFAMPICIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • VORICONAZOLE
  • NEFAZODONE
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL
  • RIFABUTIN
  • ST JOHN'S WORT
  • ENALAPRIL
  • RAMIPRIL
  • LISINOPRIL
  • AMLODIPINE
  • AMIODARONE
  • SUNITINIB

Special Advise

Females of reproductive potential and males with partners of reproductive potential must use effective contraception during treatment and for three months after the last dose.

Disease/Condition Glossary

Renal cell carcinoma: Renal cell carcinoma, also known as kidney cancer or renal cell adenocarcinoma, is a type of cancer in which cancer cells are found in the lining of tubules in the kidney. Smoking and certain pain medicines may affect the risk of renal cell cancer. Symptoms include blood in the urine, a lump in the abdomen, pain in the side that does not go away, anaemia, loss of appetite, and weight loss for no known reason.

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