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  3. Sirotrend 1mg Tablet

Sirotrend 1mg Tablet, Pack of 1 Tablet
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Sureshvarma D , MPharma
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Whats That

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Composition :

SIROLIMUS-1MG

Manufacturer/Marketer :

Anthem Bio Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

About Sirotrend 1mg Tablet

Sirotrend 1mg Tablet belongs to a class of drugs called 'immunosuppressants' used to prevent organ rejection after a transplant. Organ rejection occurs when a patient's immune system recognizes the donor organ as foreign and tries to eliminate it.

Sirotrend 1mg Tablet contains Sirolimus is an immunosuppressant. It weakens your body's defence system (immune system) to help your body accept the new organ as if it were your own. Thereby preventing organ rejection in transplanted patients and assisting the body in accepting the new organ.

Use Sirotrend 1mg Tablet as prescribed by your doctor. You are advised to use Sirotrend 1mg Tablet for as long as your doctor has prescribed it based on your medical condition. Some people may experience abdominal pain, diarrhoea, headache, fever, urinary tract infection, anaemia, nausea, arthralgia, pain, and oedema. Most of these side effects of Sirotrend 1mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

To treat your condition effectually, continue using Sirotrend 1mg Tablet for as long as your doctor has prescribed it. Do not use Sirotrend 1mg Tablet without a doctor's advice if you are allergic to Sirotrend 1mg Tablet or other medicines. Consult your doctor before using Sirotrend 1mg Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption with Sirotrend 1mg Tablet as it may increase the risk of severe adverse effects. Keep your doctor informed about your health condition and all the medicines you take before taking Sirotrend 1mg Tablet to rule out any side effects.

Uses of Sirotrend 1mg Tablet

Organ transplant rejection

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Sirotrend 1mg Tablet contains Sirolimus is an immunosuppressant. It weakens your body's defence system (immune system) to help your body accept the new organ as if it were your own. Thereby preventing organ rejection in transplanted patients and assisting the body in accepting the new organ.

Storage

Keep Sirotrend 1mg Tablet out of reach and sight of children.
Side effects of Sirotrend 1mg Tablet
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Exercise for at least 30 minutes most days of the week.
  • Limit alcohol consumption.
  • Consider a low carbohydrate diet that limits grains, starchy vegetables and fruit. Include foods rich in protein and fat.
  • Avoid excess sugar, fatty foods and carbohydrates.
  • Aim for weight loss as it helps to improve cardiovascular health and minimize the risk of complications related to obesity.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

Drug Warnings

Therapeutic drug monitoring is required for all patients receiving Sirotrend 1mg Tablet. To treat your condition effectually, continue using Sirotrend 1mg Tablet for as long as your doctor has prescribed it. Do not use Sirotrend 1mg Tablet without a doctor's advice if you are allergic to Sirotrend 1mg Tablet or other medicines. Consult your doctor before using the Sirotrend 1mg Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption with Sirotrend 1mg Tablet as it may increase the risk of severe adverse effects. Do not use Sirotrend 1mg Tablet in more than prescribed doses or longer duration as it may cause adverse effects. And also, keep your doctor informed about your health condition and all the medicines you take before taking Sirotrend 1mg Tablet to rule out any side effects.

Drug-Drug Interactions

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SirolimusVoriconazole
Critical
SirolimusCidofovir
Critical

Drug-Drug Interactions

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SirolimusVoriconazole
Critical
How does the drug interact with Sirotrend 1mg Tablet:
Coadministration of Sirotrend 1mg Tablet and Voriconazole can increase blood levels and side effects of Voriconazole.

How to manage the interaction:
Taking Voriconazole with Sirotrend 1mg Tablet is generally avoided as it can result in an interaction, please consult a doctor before taking it. Contact a doctor if you experience nausea, fever, abdominal pain, or yellowing of the skin or eyes. Do not stop using any medication without consulting a doctor.
SirolimusCidofovir
Critical
How does the drug interact with Sirotrend 1mg Tablet:
Co-administration of Cidofovir and Sirotrend 1mg Tablet can increase the risk or severity of Kidney problems.

How to manage the interaction:
Taking Sirotrend 1mg Tablet with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
SirolimusBCG vaccine
Critical
How does the drug interact with Sirotrend 1mg Tablet:
Coadministration of Sirotrend 1mg Tablet with the BCG vaccine can make the vaccine less effective.

How to manage the interaction:
Taking Sirotrend 1mg Tablet with the BCG vaccine is not recommended, they can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
SirolimusPosaconazole
Critical
How does the drug interact with Sirotrend 1mg Tablet:
Coadministration of Sirotrend 1mg Tablet with posaconazole can lower the levels of Sirotrend 1mg Tablet in the blood.

How to manage the interaction:
Although there is an interaction between posaconazole with Sirotrend 1mg Tablet, they can be taken together if a doctor advises. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SirolimusMifepristone
Critical
How does the drug interact with Sirotrend 1mg Tablet:
Coadministration of Sirotrend 1mg Tablet with Mifepristone can increase the levels of Sirotrend 1mg Tablet in the blood, which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Sirotrend 1mg Tablet with Mifepristone is not recommended, they can be taken together if a doctor advises. However, contact a doctor if you experience any symptoms like back pain · difficulty falling asleep or staying asleep, fever, headache, joint pain, rash, stomach pain, constipation, or diarrhea. Do not stop taking any medications without consulting a doctor.
SirolimusHuman immunoglobulin
Severe
How does the drug interact with Sirotrend 1mg Tablet:
Co-administration of Human immunoglobulin and Sirotrend 1mg Tablet may raise the risk or severity of kidney problems.

How to manage the interaction:
Although taking Human immunoglobulin and Sirotrend 1mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
SirolimusAmlodipine
Severe
How does the drug interact with Sirotrend 1mg Tablet:
Co-administration of Amlodipine can make Sirotrend 1mg Tablet may increase the risk of angioedema (a condition associated with swelling of the face, eyes, lips, tongue, throat, and occasionally also the hands and feet).

How to manage the interaction:
There may be a possibility of interaction between Amlodipine and Sirotrend 1mg Tablet, but it can be taken if prescribed by a doctor. However, consult the doctor if you notice any swelling of the face, eyes, lips, tongue, throat, hands and feet or have trouble breathing or swallowing. Do not stop using any medications without a doctor's advice.
SirolimusEtodolac
Severe
How does the drug interact with Sirotrend 1mg Tablet:
Coadministration of Etodolac and Sirotrend 1mg Tablet can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Sirotrend 1mg Tablet and Etodolac together can cause an interaction, it can be taken if a doctor has suggested it. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
SirolimusCisplatin
Severe
How does the drug interact with Sirotrend 1mg Tablet:
Co-administration of Cisplatin with Sirotrend 1mg Tablet can increase the risk or severity of kidney damage.

How to manage the interaction:
Although taking Sirotrend 1mg Tablet and Cisplatin together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
SirolimusLithium
Severe
How does the drug interact with Sirotrend 1mg Tablet:
Coadministration of Sirotrend 1mg Tablet with Lithium together may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Lithium and Sirotrend 1mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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SIROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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SIROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Sirotrend 1mg Tablet with Grapefruit and Grapefruit juice may increase the side effects of Sirotrend 1mg Tablet. Avoid or limit consumption of Grapefruit and Grapefruit juice while taking Sirotrend 1mg Tablet.

Side Effects of Sirotrend 1mg Tablet

  • Peripheral oedema
  • Hypertriglyceridemia
  • Hypertension
  • Hypercholesterolemia
  • Creatinine increased
  • Abdominal pain
  • Diarrhoea
  • Headache
  • Fever
  • Urinary tract infection
  • Anaemia
  • Nausea
  • Arthralgia
  • Pain
  • Thrombocytopenia

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Sirotrend 1mg Tablet Substitute

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Sureshvarma D

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:40 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Sirotrend 1mg Tablet contains Sirolimus is an immunosuppressant. It works by weakening your body's defence system (immune system) to help your body accept the new organ as if it were your own.

No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.

Sirotrend 1mg Tablet is safe if used in the dose and duration recommended by your doctor. Take it exactly as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.

Please do not stop using Sirotrend 1mg Tablet without consulting your doctor on your own. Continue using Sirotrend 1mg Tablet for as long as your doctor has prescribed it to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Sirotrend 1mg Tablet.

Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose.

Drug-Drug Interactions Checker List

  • MYCOPHENOLATE MOFETIL
  • MYCOPHENOLIC ACID
  • LORATADINE
  • LOSARTAN
  • INSULIN ASPART
  • INSULIN GLARGINE

Disease/Condition Glossary

Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Have a query?

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Alcohol

Caution

It is advised to avoid alcohol intake since it may worsen the side effects.

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Pregnancy

Caution

Consult your doctor, and there is no substantial research yet on the use of Sirotrend 1mg Tablet in pregnant women.

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Breast Feeding

Caution

Consult your doctor, and there is no substantial research yet on the use of Sirotrend 1mg Tablet in breastfeeding/nursing mothers.

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Driving

Caution

Do not drive or operate machinery if you experience dizziness or drowsiness while using Sirotrend 1mg Tablet. Sirotrend 1mg Tablet can also sometimes cause dizziness/drowsiness; hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Please consult your doctor if you have any concerns regarding using Sirotrend 1mg Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding using Sirotrend 1mg Tablet in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

There is limited information available on the use of Sirotrend 1mg Tablet in children. Please consult your doctor.

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