Sistal Plus Tablet 10'S is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, and bone and joint pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Arthritis, also known as joint inflammation, is the tenderness and swelling of the joints. Symptoms include swelling, pain, and stiffness. 
 
Sistal Plus Tablet 10'S is a combination of two drugs: Diclofenac and Trypsin-chymotrypsin. Diclofenac works by blocking the effect of chemical messengers called prostaglandins by inhibiting cyclooxygenase (COX) enzymes, thereby reducing mild to moderate pain and inflammation at the injured or damaged site. Trypsin-chymotrypsin breaks down the abnormal proteins at the site of inflammation, thereby reducing swelling and inflammation.
 
Take Sistal Plus Tablet 10'S as prescribed. Your doctor will decide the dosage of this medicine based on your condition. In some cases, you may experience some common side effects, such as nausea, vomiting, stomach pain, loss of appetite, indigestion, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor before taking Sistal Plus Tablet 10'S if you are pregnant or breastfeeding. Sistal Plus Tablet 10'S may cause dizziness, so drive with caution. Sistal Plus Tablet 10'S is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Sistal Plus Tablet 10'S as it could lead to increased dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Sistal Plus Tablet 10'S is a combination of two drugs: Diclofenac and Trypsin-chymotrypsin. Sistal Plus Tablet 10'S is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, and bone and joint pain. Diclofenac is an NSAID (Non-Steroidal Anti-Inflammatory Drug) which works by blocking the effect of chemical messengers called prostaglandins by inhibiting cyclooxygenase (COX) enzymes, thereby reducing mild to moderate pain and inflammation at the injured or damaged site. Trypsin-chymotrypsin is a combination of enzymes that breaks down the abnormal proteins at the site of inflammation, thereby reducing swelling and inflammation by increasing the blood supply at the affected area.

• Nausea
• Vomiting
• Stomach pain
• Diarrhoea
• Indigestion
• Loss of appetite

Do not take Sistal Plus Tablet 10'S if you are allergic to any of its contents; if you have/had severe heart problems, stomach ulcer or perforation, and bleeding problems such as bleeding from the stomach, intestine or brain, bypass surgery, heart attack, blood circulation problems, or inflammation of intestines. Inform your doctor before taking Sistal Plus Tablet 10'S if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, angina, bowel problems, blood clotting disorder, a habit of smoking, or liver and kidney problems. Consult your doctor before taking Sistal Plus Tablet 10'S if you are pregnant or breastfeeding. Stop taking Sistal Plus Tablet 10'S and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. If you have had any recent heart surgery, talk to your doctor before starting Sistal Plus Tablet 10'S as it may increase the risk of heart attack or stroke. Do not take any other NSAIDs for pain relief along with Sistal Plus Tablet 10'S unless prescribed by the doctor.

Drug-Drug Interactions: Sistal Plus Tablet 10'S may interact with pain killers (aspirin), anti-coagulant (warfarin, coumadin, heparin, clopidogrel), anti-depressant (duloxetine, lithium), antibiotics (chloramphenicol).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have/had a stomach ulcer or perforation, bleeding problems, bypass surgery, heart attack, blood circulation problems, inflammation of the intestines, anaemia, heart, kidney and liver problems.

• ASPIRIN
• WARFARIN
• COUMADIN
• HEPARIN
• CLOPIDOGREL
• DULOXETINE
• LITHIUM
• CHLORAMPHENICOL

• Daily exercise helps in muscle stretching, making them less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
• Massages can also be helpful.
• Avoid freezing and hot temperatures.
• Rest well. Get optimum sleep.
• To avoid developing pressure sores, change your position every two hours.
• Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot pack on the muscle for 15-20minutes.
• Stay hydrated, and drink plenty of water.
• Avoid smoking and alcohol consumption.

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp, constant, or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific area of the body). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.

Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, and loss of joint function. 

Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain generally starts in the lower back and can spread to the neck, damaged joints, or other body parts. Ankylosing spondylitis symptoms include decreased flexibility which usually leads to a hunched-forward posture and pain in the joints.