Spexib 150 mg Capsule 10's

Written By Bayyarapu Mahesh Kumar , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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About Spexib Capsule

Spexib Capsule belongs to a class of protein kinase inhibitors primarily used to manage or treat a type of lung cancer called non-small cell lung cancer that is ALK-positive, and you have already had treatment with a drug. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking.

Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

Take Spexib Capsule as prescribed. Follow your doctor's instructions to get the maximum benefit. Sometimes, you may experience certain common side effects, such as diarrhoea, feeling or being sick, abdominal pain, vomiting, fatigue (feeling overtired), decreased appetite, and weight loss. You are advised to talk to your doctor if you persistently experience any of these side effects.

Before taking the Spexib Capsule, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Spexib Capsule can cause fetal harm when in pregnancy. Contact your doctor immediately if you or your partner becomes pregnant while you are on treatment. Breastfeeding is not recommended during the treatment. Do not consume alcohol during treatment with this medicine. The safety and effectiveness of Spexib Capsule in children have not been established.

Uses of Spexib Capsule

Non-small cell lung cancer (NSCLC)

Directions for Use

Spexib Capsule should be swallowed as a whole with a glass of water. Do not crush, chew, or break the tablets. Your doctor determines the dose and duration based on your health condition.

Medicinal Benefits

Spexib Capsule contains Ceritinib, which belongs to a class of protein kinase inhibitors primarily used to manage or treat Non-small cell lung cancer (NSCLC) that is ALK-positive, and you have already had treatment with a drug. Ceritinib blocks proteins in cancer cells that encourage the cancer to grow. In some cases, if you have advanced NSCLC and have not received any other treatments, you may be prescribed Ceritinib. If you haven't had any prior therapies, you may have Ceritinib.

Storage

Keep Spexib Capsule out of reach and sight of children.

Side effects of Spexib 150 mg Capsule

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Abnormal liver function test

High levels of liver enzymes need immediate medical attention.
Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
Regularly do strengthening exercises to control your cholesterol levels.
Avoid drinking alcohol as it can affect your liver.
Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
Practice yoga and meditation to improve liver functioning and overall health.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Less Hunger

Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
Prefer foods high in fiber to help feel full for a long time.
If you have decreased appetite, eat only when you are hungry.
Eat several small meals or snacks all day.
Try to take only small sips of fluids while eating.

Drug Warnings

Before taking the Spexib Capsule, let your doctor know about all your medical conditions (especially liver disease, heart problems, QT interval prolongation, hyperglycemia, bradycardia, stomach problems and/or pancreatitis), sensitivities or allergic conditions, and all medications you are using. Exposure of an unborn child to this medication could cause birth defects, so you should not become pregnant or father a child while on this medication. Effective birth control is required throughout treatment and at least six months after treatment for women and at least three months after treatment for males. You should not breastfeed while taking this medication for two weeks after your last dose. Unless the doctor suggests, do not use any other medicine, including herbal or vitamin supplements.

Drug-Drug Interactions

CeritinibHalofantrine

Critical

CeritinibThioridazine

Critical

Drug-Drug Interactions

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CeritinibHalofantrine

Critical

How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Halofantrine can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Halofantrine is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.

CeritinibThioridazine

Critical

How does the drug interact with Spexib 150 mg Capsule:
Combining Spexib 150 mg Capsule with Thioridazine can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Thioridazine is not recommended as it can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

CeritinibMidazolam

Critical

How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule and midazolam may significantly increase the blood levels and effects of midazolam.

How to manage the interaction:
Although taking Spexib 150 mg Capsule and midazolam together may result in an interaction, they can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

CeritinibLurasidone

Critical

How does the drug interact with Spexib 150 mg Capsule:
Using Lurasidone together with Spexib 150 mg Capsule may result in significantly increase the blood levels of Lurasidone.

How to manage the interaction:
Lurasidone and Spexib 150 mg Capsule together are not recommended as they can lead to an interaction. They can be used if prescribed by a doctor. However, consult a doctor if you experience low blood pressure, such as dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. Do not discontinue any medications without consulting a doctor.

CeritinibConivaptan

Critical

How does the drug interact with Spexib 150 mg Capsule:
Taking conivaptan with Spexib 150 mg Capsule can significantly increase the blood levels and effects of conivaptan.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Conivaptan is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience difficulty swallowing, speaking, muscle weakness, controlling body movements, confusion, mood changes, and seizures(fits). Do not discontinue any medications without consulting a doctor.

CeritinibSaquinavir

Critical

How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Saquinavir may increase the risk of irregular heart rhythm and side effects.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Saquinavir is not recommended as it can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

CeritinibLovastatin

Critical

How does the drug interact with Spexib 150 mg Capsule:
Taking lovastatin with Spexib 150 mg Capsule may significantly increase the blood levels of lovastatin.

How to manage the interaction:
Although there is a interaction between Spexib 150 mg Capsule with lovastatin, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

CeritinibVenetoclax

Critical

How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Venetoclax may increase the risk of side effects.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Venetoclax is not recommended as it can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like nausea; vomiting; diarrhea; weakness; and pain while urinating, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

CeritinibRanolazine

Critical

How does the drug interact with Spexib 150 mg Capsule:
When Spexib 150 mg Capsule is taken with Ranolazine, may significantly increase the blood levels and effects of Ranolazine.

How to manage the interaction:
Taking Ranolazine with Spexib 150 mg Capsule together can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any side effects like lightheadedness, fainting, dizziness, or fast or pounding heartbeats, consult a doctor. Do not discontinue any medications without consulting a doctor.

CeritinibMesoridazine

Critical

How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with mesoridazine can increase the risk of irregular heart rhythms.

How to manage the interaction:
Although there is a interaction between Spexib 150 mg Capsule with mesoridazine it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

After your treatment begins, several dietary adjustments can help you control side effects.
Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
Eat a healthy diet and exercise regularly to maintain proper weight.
Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
Performing yoga may also help in improving both physical and mental health.
Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
Get optimal sleep; rest well.
Avoid smoking and alcohol consumption.
Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Side Effects of Spexib Capsule

Diarrhea
Feeling or being sick
Abdominal pain
Vomiting
Fatigue (feeling overtired)
Decreased appetite
Weight loss
Diarrhea
Constipation
Loss of appetite
Abdominal pain
Indigestion
Skin changes
Anaemia (few or abnormal red blood cells)

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS

Author Details

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:50 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Spexib Capsule work?

Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

What important things should I take care of while taking Spexib Capsule?

While taking Spexib Capsule, visit your doctor at all the appointments to ensure treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Spexib Capsule.

Is Ceritinib treatment known to cause pancreatitis?

Elevations of lipase and/or amylase and pancreatitis can occur during treatment. Your doctor monitors lipase and amylase prior to treatment and periodically thereafter, as clinically indicated. If clinically insignificant values are observed, your doctor either withholds them or reduces the Spexib Capsule.

Is Ceritinib therapy causing bradycardia?

In some cases, Spexib Capsule can cause bradycardia. Monitoring heart rate and blood pressure regularly is recommended. If this condition persists, Withhold the dose or permanently discontinue Spexib Capsule and consult the doctor immediately.

I am suffering from hyperglycemia. Is it safe to use Spexib Capsule?

Spexib Capsule can cause hyperglycemia. Your doctor monitors fasting glucose prior to treatment and periodically thereafter. Your doctor may prescribe anti-hyperglycemic medications, reduce the dose, or permanently discontinue Spexib Capsule if required.

Drug-Drug Interactions Checker List

DILTIAZEM
METOPROLOL
LITHIUM
AZITHROMYCIN
ERYTHROMYCIN
ESCITALOPRAM
AMPRENAVIR
ATAZANAVIR
EFAVIRENZ
FINGOLIMOD
HALOTHANE
QUINIDINE
KETOCONAZOLE
RIFAMPICIN
MIDAZOLAM
WARFARIN

Special Advise

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to Spexib Capsule.
Pregnancy testing is recommended before starting treatment with Spexib Capsule.
Do not donate sperm while on medication or within three months following completion of therapy.

Disease/Condition Glossary

Non-small cell lung cancer (NSCLC): Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking. There are various forms of non-small cell lung cancer. Different types of cancer cells are found in non-small cell lung cancer. Cancer cells of different types grow and spread in different ways. The several types of non-small cell lung cancer are called after the types of cells found in cancer and how the cells appear under a microscope.