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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
COD available

Online payment accepted

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Whats That

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Manufacturer/Marketer

Koye Pharmaceuticals Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Spiropirf 200mg Tablet

Spiropirf 200mg Tablet is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease that is marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, due to which it gets difficult to breathe deeply. The scarring makes it hard for the lungs to work properly.
 
Spiropirf 200mg Tablet contains ‘Pirfenidone’, which helps in reducing the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better. Spiropirf 200mg Tablet helps in slowing down the progress of idiopathic pulmonary fibrosis. 

In some cases, you may experience certain common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor before taking Spiropirf 200mg Tablet if you are pregnant or breastfeeding. Spiropirf 200mg Tablet may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Spiropirf 200mg Tablet as it could lead to increased dizziness. Spiropirf 200mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Spiropirf 200mg Tablet

Idiopathic pulmonary fibrosis

Directions for Use

Take Spiropirf 200mg Tablet with food. Swallow Spiropirf 200mg Tablet as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Spiropirf 200mg Tablet is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. Spiropirf 200mg Tablet can help effectively slow the rate of lung function decline by 50%. Spiropirf 200mg Tablet helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better. Spiropirf 200mg Tablet helps in slowing down the progress of idiopathic pulmonary fibrosis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Spiropirf 200mg Tablet

  • Nausea
  • Tiredness
  • Diarrhoea
  • Indigestion/Stomach upset
  • Loss of appetite
  • Headache
  • Photosensitivity

Drug Warnings

Do not take Spiropirf 200mg Tablet if you are allergic to any of its components; if you have a severe or end-stage liver impairment or kidney disease requiring dialysis; if you are taking fluvoxamine (anti-depressant). Inform your doctor if you are taking any medicines that might make you photosensitive, if you smoke or have kidney or liver problems. Consult your doctor before taking Spiropirf 200mg Tablet if you are pregnant or breastfeeding. Spiropirf 200mg Tablet may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Spiropirf 200mg Tablet as it could lead to increased dizziness. Spiropirf 200mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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PirfenidonePhenobarbital
Critical
PirfenidonePrimidone
Critical

Drug-Drug Interactions

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PirfenidonePhenobarbital
Critical
How does the drug interact with Spiropirf 200mg Tablet:
When Spiropirf 200mg Tablet is taken with Phenobarbital, it can decrease the effects of Spiropirf 200mg Tablet.

How to manage the interaction:
Taking Spiropirf 200mg Tablet with Phenobarbital is not recommended but can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
PirfenidonePrimidone
Critical
How does the drug interact with Spiropirf 200mg Tablet:
Coadministration of Spiropirf 200mg Tablet with primidone can reduce levels and the effects of Spiropirf 200mg Tablet.

How to manage the interaction:
Although there is an interaction between Spiropirf 200mg Tablet and primidone, they can be taken together if advised by your doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneRifampicin
Critical
How does the drug interact with Spiropirf 200mg Tablet:
Taking Spiropirf 200mg Tablet with rifampicin can reduce the levels and effects of Spiropirf 200mg Tablet

How to manage the interaction:
Although there is an interaction between Spiropirf 200mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneCarbamazepine
Critical
How does the drug interact with Spiropirf 200mg Tablet:
Taking Spiropirf 200mg Tablet with Carbamazepine it reduces the levels and effects of Spiropirf 200mg Tablet.

How to manage the interaction:
Taking Spiropirf 200mg Tablet with Carbamazepine is not recommended but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
PirfenidoneEnoxacin
Severe
How does the drug interact with Spiropirf 200mg Tablet:
When Enoxacin is taken with Spiropirf 200mg Tablet, it can increase the levels of Spiropirf 200mg Tablet, which may lead to side effects.

How to manage the interaction:
Although taking Spiropirf 200mg Tablet and Enoxacin together can cause an interaction, it can be taken if your doctor has suggested it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneViloxazine
Severe
How does the drug interact with Spiropirf 200mg Tablet:
When Viloxazine is taken with Spiropirf 200mg Tablet, it can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Spiropirf 200mg Tablet and Viloxazine, you can take these medicines together if prescribed by your doctor. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately.
PirfenidoneFluvoxamine
Severe
How does the drug interact with Spiropirf 200mg Tablet:
When Spiropirf 200mg Tablet is taken with Fluvoxamine, it can increase the risk of side effects.

How to manage the interaction:
Taking Spiropirf 200mg Tablet with Fluvoxamine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneTeriflunomide
Severe
How does the drug interact with Spiropirf 200mg Tablet:
Taking Teriflunomide with Spiropirf 200mg Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Spiropirf 200mg Tablet and Teriflunomide together can cause an interaction, it can be taken if your doctor has suggested it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
PirfenidoneAmiodarone
Severe
How does the drug interact with Spiropirf 200mg Tablet:
Co-administration of Amiodarone and Spiropirf 200mg Tablet may raise the risk of liver issues.

How to manage the interaction:
Even though Amiodarone and Spiropirf 200mg Tablet interact, they can be used if a doctor prescribes them. Seek medical attention if you have a fever, chills, joint pain or swelling, unusual bleeding or bruises, skin rash, itching, lack of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, or yellowing of the skin or eyes. Do not stop taking any medications without visiting a doctor.
PirfenidoneMipomersen
Severe
How does the drug interact with Spiropirf 200mg Tablet:
Taking Mipomersen with Spiropirf 200mg Tablet may increase the risk of liver damage.

How to manage the interaction:
Taking Spiropirf 200mg Tablet with Mipomersen together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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PIRFENIDONE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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PIRFENIDONE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grape fruit and its products while using Spiropirf 200mg Tablet can increase the risk of side effects. Avoid grape fruit and its products during treatment with Spiropirf 200mg Tablet.

Diet & Lifestyle Advise

  • Watch out for triggers that make the cough worse, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow the pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and fruit juices.
  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Spiropirf 200mg Tablet Substitute

Substitutes safety advice
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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Spiropirf 200mg Tablet helps in reducing the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better.

Spiropirf 200mg Tablet might make you photosensitive (sensitivity to sunlight). Avoid exposure to sunlight and sunlamps. Wear SPF 50+ sunscreen and protective clothing to reduce exposure to sunlight. Talk to your doctor if you are taking any medicines known to cause photosensitivity. If you notice any symptoms of photosensitivity, consult a doctor.

Do not discontinue Spiropirf 200mg Tablet without consulting your doctor. To treat your condition effectually, continue taking Spiropirf 200mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Spiropirf 200mg Tablet .

Diarrhoea might be a side-effect of Spiropirf 200mg Tablet . Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you have severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

No, avoid smoking prior to the start of the treatment and while taking Spiropirf 200mg Tablet as smoking might alter the effectiveness of Spiropirf 200mg Tablet .

Weight loss could occur due to loss of appetite. Maintain proper weight by eating healthy food. Your doctor might monitor your weight whilst taking Spiropirf 200mg Tablet . Consult your doctor if you notice severe weight loss.

Drug-Drug Interactions Checker List

  • FLUVOXAMINE
  • CIPROFLOXACIN
  • ENOXACIN
  • RIFAMPICIN
  • AMIODARONE
  • PROPAFENONE
  • OMEPRAZOLE

Special Advise

  • Your doctor may advise liver function tests prior to the start of the treatment.
  • Regular blood tests are advised at the start of treatment with Spiropirf 200mg Tablet and monthly for every 6 months, and then for every 3 months thereafter to check the liver functioning.

Disease/Condition Glossary

Idiopathic pulmonary fibrosis (IPF): Idiopathic pulmonary fibrosis belongs to a group of interstitial lung diseases. It is an irreversible chronic disease marked by a progressive decline in lung function. The tissues in the lungs become inflamed and scarred over time, due to which it gets difficult to breathe properly. The scar tissue, known as fibrosis, becomes thick /stiff over time, making it hard for the lungs to work efficiently. This causes decreased lung function, which leads to increased breathlessness and coughing. Breathing difficulties can lead to other medical problems. Symptoms of IPF are shortness of breath, persistent dry cough, loss of appetite, weight loss, rounded and widened tips of the fingers and toes.

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