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  3. SPIZEF 1500MG INJECTION

SPIZEF 1500MG INJECTION, Pack of 1 Injection
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Non returnable*
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Whats That

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Composition :

CEFUROXIME-1500MG

Manufacturer/Marketer :

Med Manor Organics Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About SPIZEF 1500MG INJECTION

SPIZEF 1500MG INJECTION belongs to the class of cephalosporin antibiotics indicated to treat a wide range of bacterial infections including lower respiratory tract infections, urinary tract infections, skin and skin structure infections, septicemia (blood infection), meningitis (infection of brain and spinal cord), gonorrhoea (sexually transmitted infections), bone and joint infections. SPIZEF 1500MG INJECTION is also used to prevent infections during surgery. 

SPIZEF 1500MG INJECTION is a broad-spectrum antibiotic that acts against a wide range of bacteria. It works by blocking the activity of an enzyme that makes peptidoglycan (a vital component of the bacterial cell wall). This prevents the formation of bacterial cell covering, thereby kills the bacteria and treats bacterial infection.

A healthcare expert will administer SPIZEF 1500MG INJECTION; do not self-administer. In some cases, SPIZEF 1500MG INJECTION may cause side effects such as diarrhoea, nausea, vomiting, pain, and swelling at the site of injection. Most of these side effects do not require medical attention and resolve over time. However, if the side effects persist or worsen, consult your doctor.

Let your doctor know about your medical condition and the medications you are taking to avoid the occurrence of potential interactions. Consult your doctor if you are pregnant, breastfeeding, suspect you are pregnant or plan to have a baby; your doctor will weigh the benefits of SPIZEF 1500MG INJECTION therapy against the risk to your baby. SPIZEF 1500MG INJECTION may cause dizziness, so drive only if you are alert.

Uses of SPIZEF 1500MG INJECTION

Bacterial infections

Directions for Use

SPIZEF 1500MG INJECTION will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

SPIZEF 1500MG INJECTION is used to treat respiratory tract infections, ear infections, skin infections, genitourinary infections, and bone infections. Besides this, SPIZEF 1500MG INJECTION is also used to prevent infection after surgery and in the early treatment of Lyme disease caused by bacteria (Borrelia burgdorferi) in adults and children over the age of 12 years. SPIZEF 1500MG INJECTION is a broad-spectrum antibiotic that acts against a wide range of bacteria. It works by blocking the activity of an enzyme that makes peptidoglycan (a vital component of the bacterial cell wall). This prevents the formation of bacterial cell covering, thereby kills the bacteria and treats bacterial infection.

Storage

Store in a cool and dry place away from sunlight
Side effects of Spizef 1500mg Injection
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
  • Notify your doctor about the fever caused by medication and follow their guidance to adjust or stop the medication.
  • Drink plenty of fluids, like water or electrolyte-rich beverages, and eat healthy food.
  • Get plenty of rest to help your body recover or adjust to the medication.
  • Track your temperature and report changes to your doctor.
  • Use fever-reducing medications like acetaminophen if recommended.

Drug Warnings

Do not take SPIZEF 1500MG INJECTION if you are allergic to any of the contents. Consult your doctor if you are pregnant or breastfeeding. Inform your doctor if you have kidney or liver problems. SPIZEF 1500MG INJECTION may cause Clostridioides difficile-associated diarrhoea (CDAD). If you experience a severe, persistent diarrhoea, or if you find blood or mucus in stools, consult your doctor immediately. Let your doctor know about your medical condition and the medications you are taking to avoid the occurrence of potential interactions.

Drug-Drug Interactions

verifiedApollotooltip
CefuroximeBCG vaccine
Severe
CefuroximeLepirudin
Severe

Drug-Drug Interactions

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CefuroximeBCG vaccine
Severe
How does the drug interact with Spizef 1500mg Injection:
Co-administration of Spizef 1500mg Injection may reduce the anti-tumor activity of BCG in the bladder.

How to manage the interaction:
Talk to your doctor before receiving BCG if you are currently being treated with Spizef 1500mg Injection. To ensure adequate response to your treatment, you should not receive BCG until after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.
CefuroximeLepirudin
Severe
How does the drug interact with Spizef 1500mg Injection:
The therapeutic efficacy of Lepirudin can be decreased when used in combination with Spizef 1500mg Injection.

How to manage the interaction:
Although taking Spizef 1500mg Injection and Lepirudin together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
CefuroximeDalteparin
Severe
How does the drug interact with Spizef 1500mg Injection:
Co-administration of Dalteparin and Spizef 1500mg Injection can increase the blood levels and effects of Dlateparin.

How to manage the interaction:
Taking Spizef 1500mg Injection with Dalteparin together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
CefuroximeRanitidine
Moderate
How does the drug interact with Spizef 1500mg Injection:
Taking these medications together might make it harder for your body to absorb atazanavir, which could make it less effective.

How to manage the interaction:
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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After completing the course of SPIZEF 1500MG INJECTION, probiotics should be taken to restore healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. 
  • Avoid taking too much calcium enriched foods and drinks as it might affect the working of SPIZEF 1500MG INJECTION.
  • Avoid intake of alcoholic beverages with SPIZEF 1500MG INJECTION as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid SPIZEF 1500MG INJECTION in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

SPIZEF 1500MG INJECTION Substitute

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 8, 2025 | 9:45 AM IST

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Drug-Diseases Interactions

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CEFUROXIME-1500MGOther gastroenteritis and colitis of infectious and unspecified origin
Severe
CEFUROXIME-1500MGChronic kidney disease
Moderate

Drug-Diseases Interactions

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CEFUROXIME-1500MGOther gastroenteritis and colitis of infectious and unspecified origin
Severe
How does the disease interact with Spizef 1500mg Injection:
Colitis: In some cases the use of Spizef 1500mg Injection may cause ranging from mild diarrhea to fatal colitis. Colitis is commonly Clostridioides difficile-associated diarrhea (CDAD). Discontinue therapy if signs of CDAD are confirmed.

How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Spizef 1500mg Injection should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the colon) or pseudomembranous colitis (a severe inflammation of the inner lining of the large intestine). Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
CEFUROXIME-1500MGChronic kidney disease
Moderate
How does the disease interact with Spizef 1500mg Injection:
Renal dysfunction: Spizef 1500mg Injection is eliminated by the kidney in an unchanged form. Thus the plasma levels of the drug increase and prolongs the half-life. Adjust the doses of Spizef 1500mg Injection as necessary.

How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised during prolonged or high-dose therapy.
CEFUROXIME-1500MGDependence on enabling machines and devices, not elsewhere classified
Moderate
How does the disease interact with Spizef 1500mg Injection:
Dialysis : Most of the antibiotics are eliminated by hemodialysis. Therefore, administer Spizef 1500mg Injection after dialysis or an additional dosage to be administered.

How to manage the interaction:
Spizef 1500mg Injection serum levels may be decreased by hemodialysis and peritoneal dialysis. Supplemental doses should be given at the end of each hemodialysis session.
CEFUROXIME-1500MGConvulsions, not elsewhere classified
Moderate
How does the disease interact with Spizef 1500mg Injection:
seizure disorders: In some patients, seizures were reported with whom renal dysfunction which incase of dosage adjustment was not done. Discontinue Spizef 1500mg Injection if seizures are reported.

How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Spizef 1500mg Injection should be discontinued if seizures associated with drug therapy occur.
CEFUROXIME-1500MGOther diseases of liver
Moderate
How does the disease interact with Spizef 1500mg Injection:
liver disease: With Spizef 1500mg Injection, a transient increase in the AST, ALT, and alkaline phosphatase levels was observed. Use with caution and closely monitor for hepatic function is recommended.

How to manage the interaction:
Caution and monitoring is recommended in patients with liver disease as cases of hepatitis have been reported with the use of certain cephalosporins.
CEFUROXIME-1500MGOther diseases of liver
Moderate
How does the disease interact with Spizef 1500mg Injection:
Rarely, cephalosporins use may cause hypoprothrombinemia, with or without bleeding. Monitor for Prothrombin time.

How to manage the interaction:
Cephalosporins may be associated with reduced prothrombin activity/prolonged prothrombin time (blood takes too long to form a clot). Prothrombin time should be monitored in at-risk patients and managed as needed.

FAQs

Drug-Drug Interactions Checker List

  • GENTAMICIN
  • NEOMYCIN
  • FUROSEMIDE
  • PROBENECID
  • WARFARIN
  • LEVONORGESTREL
  • MEDROXYPROGESTERONE
  • BCG VACCINE
  • CHOLERA VACCINE LIVE
  • TYPHOID VACCINE LIVE

Special Advise

  • Regular monitoring of blood count, haemoglobin levels, renal and liver function tests are recommended.
  • SPIZEF 1500MG INJECTION might affect lab test results. Inform the person doing the tests that you are taking SPIZEF 1500MG INJECTION.

Disease/Condition Glossary

Bacterial infection: A bacterial infection is a condition in which harmful bacteria enter, multiply and infect the body. It can target any body part and multiply very quickly. When you get infected with bacteria, you can experience generalized symptoms like fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicine are more prone to bacterial infection.

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