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  3. Syncapone 50 Tablet 10's

Syncapone 50 Tablet 10's, Pack of 10 TABLETS
Syncapone 50 Tablet 10's, Pack of 10 TABLETS
Syncapone 50 Tablet 10's, Pack of 10 TABLETS
Syncapone 50 Tablet 10's, Pack of 10 TABLETS
Syncapone 50 Tablet 10's, Pack of 10 TABLETS
Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS
Non returnable*
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Whats That

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Composition :

CARBIDOPA-12.5MG + ENTACAPONE-200MG + LEVODOPA-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Syncapone 50 Tablet

Syncapone 50 Tablet belongs to a class of drugs called 'antiparkinson agents', a precursor of dopamine (chemical messenger in the brain) primarily used in treating Parkinson's disease with its symptoms including tremors, spasms, muscle stiffness and poor muscle control. Parkinson's disease is a disorder of the central nervous system that affects movement and locomotion, which causes stiffness, shaking, and difficulty in walking, coordination and balance. In Parkinson's patients, there are low dopamine levels as the nerve cells of the brain (neurons) that produce dopamine begin to die.

Syncapone 50 Tablet contains Carbidopa, Levodopa, and Entacapone. Levodopa belongs to the central nervous system agents, while Carbidopa is a decarboxylase inhibitor. The medicinal component Levodopa changes into dopamine in the brain and helps to control movement. Carbidopa prevents the breakdown of Levodopa in the bloodstream so that more Levodopa can reach the brain. On the other hand, Entacapone belongs to a class of COMT (catechol-o-methyltransferase enzyme) inhibitors which causes higher and more sustained levels of Levodopa in the blood that more Levodopa can reach the brain, leading to greater relief from the symptoms of Parkinson's disease.

Take Syncapone 50 Tablet as prescribed by your doctor. You are suggested to take $ame as long as your doctor has prescribed it after checking your medical condition. The most common side effects of Syncapone 50 Tablet are nausea, vomiting, loss of appetite, light-headedness, lowered blood pressure, confusion, and dyskinesia (uncontrolled/involuntary muscle movement). Most of these side effects of Syncapone 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Syncapone 50 Tablet or any other medicines, please tell your doctor. Do not take Syncapone 50 Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Syncapone 50 Tablet should not be given to children as safety and effectiveness have not been established. Syncapone 50 Tablet may cause hallucinations (seeing or hearing things that are not there) in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Syncapone 50 Tablet , please talk to your doctor immediately. Keep your doctor informed about your medicines and health condition and rule out any side effects.

Uses of Syncapone 50 Tablet

Parkinson’s disease

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Syncapone 50 Tablet is an antiparkinson agent that is used in the treatment of Parkinson’s disease. Syncapone 50 Tablet is a combination of three medicines: Carbidopa, Levodopa, and Entacapone. Levodopa belongs to the class of medications name as central nervous system agents, While Carbidopa falls in decarboxylase inhibitors. The medicinal component Levodopa changes into dopamine in the brain and helps to control movement. At the same time, Carbidopa acts by preventing the breakdown of Levodopa in the bloodstream so that more Levodopa can effectively reach the brain to block acetylcholine (a chemical messenger in the brain). Entacapone blocks a certain natural substance, catechol-o-methyltransferase (COMT) (an enzyme that breaks down the levodopa in the body), which causes higher and more sustained levels of levodopa in the blood, so that more Levodopa can reach the brain, leading to greater relief from the symptoms of Parkinson’s disease. This effect allows the levodopa to last longer in the body so that it doesn't wear off before the next dose.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not stop taking Syncapone 50 Tablet suddenly without talking to your doctor. It may result in a serious neuroleptic malignant syndrome (NMS) that causes fever, muscle cramps or stiffness, unusual body movements, fast heartbeat, sweating, change in thinking, and confusion. Do not take Syncapone 50 Tablet if you are allergic to Syncapone 50 Tablet or any of its ingredients. Tell your doctor if you have any medical history of diabetes, heart attacks, mental illness, stomach ulcers, heart disease, or have recently undergone a surgical procedure. Syncapone 50 Tablet may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, especially when you start taking Syncapone 50 Tablet so please get up gradually. Besides this, a prolonged intake of Syncapone 50 Tablet may lead to greater neuropathy chances (nerve damage). Syncapone 50 Tablet should be given with caution in patients with eye problems (narrow-angle glaucoma), irregular heartbeat (arrhythmia), gastrointestinal bleeding, and psychosis. The use of Syncapone 50 Tablet is restricted if a person takes monoamine oxidase inhibitors (MAOs) or antidepressant drugs like isocarboxazid, phenelzine, selegiline, and tranylcypromine because it can lead to high blood pressure (hypertension) crisis.

Drug-Drug Interactions

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EntacaponePhenelzine
Critical
EntacaponeIsocarboxazid
Critical

Drug-Drug Interactions

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EntacaponePhenelzine
Critical
How does the drug interact with Syncapone 50 Tablet:
Combining Syncapone 50 Tablet with Phenelzine can increase the risk of serious condition called the serotonin syndrome.

How to manage the interaction:
Taking Syncapone 50 Tablet with Phenelzine is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeIsocarboxazid
Critical
How does the drug interact with Syncapone 50 Tablet:
Combining Syncapone 50 Tablet with Isocarboxazid can increase the risk of serious condition called the serotonin syndrome.

How to manage the interaction:
Taking Syncapone 50 Tablet with Isocarboxazid is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, Contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeLinezolid
Critical
How does the drug interact with Syncapone 50 Tablet:
Coadministration of Syncapone 50 Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Syncapone 50 Tablet with Linezolid is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeTranylcypromine
Critical
How does the drug interact with Syncapone 50 Tablet:
Coadministration of Syncapone 50 Tablet with Tranylcypromine can increase the risk of high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Syncapone 50 Tablet with Tranylcypromine can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
LevodopaTranylcypromine
Critical
How does the drug interact with Syncapone 50 Tablet:
Taking Tranylcypromine with Syncapone 50 Tablet can increase the risk of high blood pressure

How to manage the interaction:
Taking Syncapone 50 Tablet with Tranylcypromine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
LevodopaPhenelzine
Critical
How does the drug interact with Syncapone 50 Tablet:
Using Syncapone 50 Tablet together with phenelzine can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking Syncapone 50 Tablet with Phenelzine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
LevodopaProcarbazine
Critical
How does the drug interact with Syncapone 50 Tablet:
Using Syncapone 50 Tablet together with procarbazine can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking Procarbazine with Syncapone 50 Tablet together can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
EntacaponeProcarbazine
Severe
How does the drug interact with Syncapone 50 Tablet:
Combining Syncapone 50 Tablet with Procarbazine can increase the risk or severity of side effects like decreased rate of breathing, decreased heart rate, and loss of consciousness.

How to manage the interaction:
Although taking Syncapone 50 Tablet and Procarbazine together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like confusion, hallucinations, seizures, fast heartbeat, fever, sweating, shivering, blurred vision, muscle spasms, stiffness, trouble moving, cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
EntacaponeFurazolidone
Severe
How does the drug interact with Syncapone 50 Tablet:
Combining Syncapone 50 Tablet with Furazolidone can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although there is a possible interaction between Syncapone 50 Tablet and Furazolidone, you can take these medicines together if prescribed by your doctor. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling really unwell, confusion, seeing or hearing things that aren't there, having a seizure, a faster heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty moving, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
EntacaponeEsketamine
Severe
How does the drug interact with Syncapone 50 Tablet:
Combining Syncapone 50 Tablet with Esketamine can increase the risk and severity of side effects (drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination).

How to manage the interaction:
Although taking Syncapone 50 Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like feeling sleepy, having trouble concentrating, or feeling confused, it's important to let a doctor know right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Drink plenty of water to avoid headaches due to dehydration. 
  • Limit the consumption of sugar-containing food or food with too many calories but fewer nutrients, as it may cause tooth decay.
  • Engaging in physical activity like dancing or exercising will boost the metabolism and make a person more energetic.
  • Avoid intake of alcoholic beverages with Syncapone 50 Tablet as it can make a person dehydrated and may affect their sleep. This can make it harder for a person’s body to aid the Syncapone 50 Tablet in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Syncapone 50 Tablet Substitute

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Author Details

Doctor image

Written By

Urvashi Bharti

MBBS

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:34 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Syncapone 50 Tablet is a combination of three medicines namely; Carbidopa, Levodopa, and Entacapone. Levodopa belongs to the class of medications name as central nervous system agents, While Carbidopa fall in the category of decarboxylase inhibitors. The medicinal component Levodopa changes into dopamine in the brain and helps to control movement. While Carbidopa and Entacapone act by preventing the breakdown and causes higher and more sustained levels of Levodopa in the bloodstream so that more Levodopa can reach to brain.

Take Syncapone 50 Tablet medicine precisely as the doctor has directed. Take one dose on a regular basis. Try to take the tablets at the same time of day every day, as this will assist you in making sure to take them.

In some cases, prolonged intake of Syncapone 50 Tablet may lead to autoimmune hemolytic anaemia (red blood cells in the blood are destroyed earlier than normal). Levodopa in Syncapone 50 Tablet can cause the immune system to mistake your own red blood cells for foreign substances. The body responds by making antibodies to attack the body's own red blood cells. The antibodies attach to red blood cells and cause them to break down too early. So, your doctor might recommend regular blood tests while using Syncapone 50 Tablet .

You are recommended to avoid taking protein-rich food (such as chicken, beef, pork, eggs, meats, fish, dairy products, seeds, and nuts), iron supplements, or multivitamin tablets while taking Syncapone 50 Tablet as it may delay and reduce the absorption of levodopa. Thus, reduce the effectiveness of Syncapone 50 Tablet . Please consult your doctor and do as advised for the best results.

Yes, orthostatic hypotension could be a side-effect of Syncapone 50 Tablet . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better. People taking Syncapone 50 Tablet are advised to regularly monitor their blood pressure levels to avoid unpleasant events.

Consult your doctor before taking Syncapone 50 Tablet if you have glaucoma. Syncapone 50 Tablet is contraindicated in patients with narrow-angle glaucoma. Syncapone 50 Tablet may cause blindness on long-term use in the case of patients with narrow-angle glaucoma.

Hallucination is a medical condition in which the person may feel, hear, or believe things that are not true, see things that are not there, or feel unusually suspicious or confused. Syncapone 50 Tablet may cause hallucinations in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Syncapone 50 Tablet , please talk to your doctor immediately.

It is advised not to stop taking Syncapone 50 Tablet without consulting your doctor as it may lead to a severe condition called withdrawal-emergent hyperpyrexia with symptoms such as confusion, fever, muscle stiffness, changes in heartbeat, and breathing. Therefore, take Syncapone 50 Tablet for as long as your doctor has prescribed it and if you experience any of these symptoms while taking Syncapone 50 Tablet , please consult your doctor so that the dose may be gradually reduced.

Drug-Drug Interactions Checker List

  • RASAGILINE
  • SELEGILINE
  • PRAMIPEXOLE
  • APOMORPHINE
  • MOCLOBEMIDE
  • AMITRIPTYLINE
  • DESIPRAMINE
  • MAPROTILINE
  • VENLAFAXINE
  • PAROXETINE
  • ISOPRENALINE
  • ADRENALINE
  • METHYLDOPA
  • FUROSEMIDE
  • ATORVASTATIN
  • PYRIDOXINE (VITB6)
  • PHENYTOIN
  • METOCLOPRAMIDE
  • PHENOTHIAZINE
  • RISPERIDONE
  • ERYTHROMYCIN
  • RIFAMPICIN
  • AMPICILLIN
  • CHLORAMPHENICOL
  • ISONIAZID
  • NORADRENALINE
  • RIMITEROLE
  • PAPAVERINE
  • BUTYROPHENONES

Special Advise

  • Do not exceed more than 1 dose (2 capsules) for any off period (recurring symptoms in between regular doses).
  • If you have unusual urges like gambling, spending money, overeating, or increased sexual urges, please inform your doctor before taking the Syncapone 50 Tablet .

Disease/Condition Glossary

Parkinson’s disease: It is a disorder of central nervous system that affects movement due to damage of nerve cells in the brain which reduces the levels of dopamine and leads to symptoms such as stiffness, tremor in one hand, shaking, difficulty in walking, coordination and balance. This condition can last for many years or life-long. Treatment with medicines along with physiotherapy may help to control the symptoms and provide a quality life for as long as possible.

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