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  3. Synclar 500mg Infusion

Synclar 500mg Infusion, Pack of 1 Injection
Synclar 500mg Infusion, Pack of 1 Injection
Synclar 500mg Infusion, Pack of 1 Injection
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Non returnable*
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Whats That

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Composition :

CLARITHROMYCIN-500MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Synclar 500mg Infusion

Synclar 500mg Infusion belongs to the group of medicines known as macrolide antibiotics used to treat infections caused by bacteria such as bronchitis, pneumonia, throat, sinus, skin and soft tissue infections. It is prescribed for treating severe infections or when oral therapy is ineffective. A bacterial infection is a condition in which bacteria grow in the body and cause infection. It can target any body part and multiply very quickly.

Synclar 500mg Infusion contains 'Clarithromycin', which works by killing the bacteria that cause the infection by preventing the synthesis of essential proteins necessary for the survival of the bacteria. Thereby, it effectively treats bacterial infections.

Synclar 500mg Infusion will be administered by a healthcare professional; do not self-administer. You may experience injection site phlebitis (redness, swelling, and pain), headache, nausea (feeling sick) or vomiting (being sick), stomach cramps or tummy pain, and diarrhoea. Most of these side effects of Synclar 500mg Infusion do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

Inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby or if you are breastfeeding; your doctor will prescribe Synclar 500mg Infusion only if the benefits outweigh the risk. Let your doctor know if you have/had liver problems; your doctor may need to monitor your liver function. Synclar 500mg Infusion may cause dizziness, confusion, and loss of balance. If you experience these, you should not drive or operate machinery. Let your doctor know about your medical condition and the medications you are taking to avoid any interactions.

Uses of Synclar 500mg Infusion

Bacterial infections

Directions for Use

Synclar 500mg Infusion will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Synclar 500mg Infusion belongs to the group of medicines known as macrolide antibiotics used to treat infections caused by bacteria such as lower respiratory tract infections (acute and chronic bronchitis and pneumonia), upper respiratory tract infections (sinusitis and pharyngitis), and skin & soft tissue infections [folliculitis (inflammation of hair follicles), erysipelas (large raised red patches on the skin), cellulitis (bacterial skin infection)]. Synclar 500mg Infusion works by preventing the production of proteins required by the bacteria for its survival. Thereby killing the bacteria and treating infections. Synclar 500mg Infusion is prescribed for treating severe infections or when oral therapy is ineffective. 

Storage

Store in a cool and dry place away from sunlight
Side effects of Synclar 500mg Infusion
  • Use a warm compress on the affected area to help reduce discomfort.
  • Elevate the affected limb above heart level.
  • Remove the IV catheter (if applicable) and reinsert at a different site.
  • Consult your healthcare provider if symptoms are severe or persist.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug Warnings

Do not take Synclar 500mg Infusion if you are allergic or hypersensitive to clarithromycin, any of the ingredients in Synclar 500mg Infusion, any other macrolide antibiotic, or ketolide (macrolide derivatives). Consult your doctor if you are pregnant or breastfeeding. Inform your doctor if you have/had hypokalemia (abnormally low levels of potassium in the blood), hypomagnesemia (abnormally low levels of magnesium in the blood), severe kidney or liver problems, heart rhythm disorders, heart problems, or are prone to fungal infections (e.g. thrush).

Drug-Drug Interactions

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ClarithromycinTerfenadine
Critical
ClarithromycinQuinidine
Critical

Drug-Drug Interactions

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ClarithromycinTerfenadine
Critical
How does the drug interact with Synclar 500mg Infusion:
When Terfenadine is taken with Synclar 500mg Infusion, the amount of Terfenadine in the blood can go up.

How to manage the interaction:
Co-administration of Synclar 500mg Infusion and Terfenadine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinQuinidine
Critical
How does the drug interact with Synclar 500mg Infusion:
When Quinidine is taken with Synclar 500mg Infusion, can increase the blood levels and effects of Quinidine. This may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Synclar 500mg Infusion and Quinidine can lead to an interaction, it can be taken if advised by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats. However, if you experience any symptoms like headache, confusion, vomiting, diarrhea, ringing in the ears, hearing loss, blurred or double vision, or sensitivity to light, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinLurasidone
Critical
How does the drug interact with Synclar 500mg Infusion:
Using Lurasidone together with Synclar 500mg Infusion may result in significantly higher Lurasidone blood levels. This may increase the possibility of side effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Lurasidone and Synclar 500mg Infusion may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
ClarithromycinNaloxegol
Critical
How does the drug interact with Synclar 500mg Infusion:
When Naloxegol is taken with Synclar 500mg Infusion, the amount of Naloxegol in the blood can go up.

How to manage the interaction:
Co-administration of Synclar 500mg Infusion and Naloxegol can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like sweating, tearing, runny nose, chills, diarrhea, abdominal pain, anxiety, insomnia, irritability, restlessness, and yawning, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinDronedarone
Critical
How does the drug interact with Synclar 500mg Infusion:
When Dronedarone is taken with Synclar 500mg Infusion, can increase the blood levels of dronedarone and cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Synclar 500mg Infusion with Dronedarone can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinBepridil
Critical
How does the drug interact with Synclar 500mg Infusion:
Co-administration of Bepridil with Synclar 500mg Infusion may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Synclar 500mg Infusion with Bepridil is not recommended as it can result in an interaction, it should be taken only if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinZiprasidone
Critical
How does the drug interact with Synclar 500mg Infusion:
Taking Synclar 500mg Infusion with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Synclar 500mg Infusion and Ziprasidone can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinLovastatin
Critical
How does the drug interact with Synclar 500mg Infusion:
Taking Synclar 500mg Infusion with Lovastatin can increase the risk of muscle problems.

How to manage the interaction:
Co-administration of Synclar 500mg Infusion and Lovastatin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinErgotamine
Critical
How does the drug interact with Synclar 500mg Infusion:
When Ergotamine is taken with Synclar 500mg Infusion, the amount of Ergotamine in the blood can go up.

How to manage the interaction:
Taking Synclar 500mg Infusion with Ergotamine can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinAlprazolam
Critical
How does the drug interact with Synclar 500mg Infusion:
The combination of Alprazolam and Synclar 500mg Infusion may considerably increase the risk of side effects.

How to manage the interaction:
Despite the fact that there is an interaction between Alprazolam and Synclar 500mg Infusion, it can be used if prescribed by a doctor. Consult a doctor if you have excessive drowsiness, problems with movement, memory loss, anxiety, hallucinations (illogical thoughts), or breathing issues (particularly if you have asthma or obstructive sleep apnea). Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take probiotics after completing the full course of Synclar 500mg Infusion to restore healthy bacteria in the intestine that may have been killed due to the use of antibiotics. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Whole grains like whole-grain bread, and brown rice, should be included in the diet.
  • Avoid intake of alcoholic beverages with Synclar 500mg Infusion as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid Synclar 500mg Infusion in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

Synclar 500mg Infusion Substitute

Substitutes safety advice

Product Substitutes

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 8, 2025 | 9:46 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
CLARITHROMYCIN-500MGOther bacterial intestinal infections
Severe
CLARITHROMYCIN-500MGToxic liver disease
Moderate

Drug-Diseases Interactions

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CLARITHROMYCIN-500MGOther bacterial intestinal infections
Severe
How does the disease interact with Synclar 500mg Infusion:
Almost all antibacterial medications have been associated with cases of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis. Clindamycin and lincomycin are two of the most frequent those involved.

How to manage the interaction:
Anti-bacterial medicines may cause Clostridioides difficile-associated diarrhea (CDAD) ranging from mild diarrhoea to colitis. Therapy should be administered with caution in patients with history of gastrointestinal disease, particularly colitis and pseudomembranous colitis. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile is advised.
CLARITHROMYCIN-500MGToxic liver disease
Moderate
How does the disease interact with Synclar 500mg Infusion:
Patients on Synclar 500mg Infusion have been reported to experience hepatic dysfunction, including elevated liver enzymes, cholestatic and/or hepatocellular hepatitis, with or without jaundice. Using this medication to patients with hepatic impairment requires caution and close monitoring. If hepatitis signs and symptoms appear, treatment must be stopped.

How to manage the interaction:
Caution and monitoring is advised if Synclar 500mg Infusion is used in patients with liver impairment. Treatment must be discontinued immediately if signs and symptoms of hepatitis such as anorexia, jaundice, dark urine, pruritus, or tender abdomen occur. The use of Synclar 500mg Infusion is contraindicated in patients with a history of cholestatic jaundice or liver impairment associated with the prior use of Synclar 500mg Infusion.
CLARITHROMYCIN-500MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Synclar 500mg Infusion:
The kidney and liver are the organs that eliminate of Synclar 500mg Infusion the most. In individuals with severe renal impairment (CrCl 30 mL/min), a lower dose or longer dosing intervals are advised. Patients with mild to moderate renal impairment often do not require dosage modifications, while medication accumulation may happen if there is concurrent liver illness. It is suggested to monitor.

How to manage the interaction:
Dose adjustment may be needed in patients with severe kidney impairment. Monitoring is advised in patients with mild to moderate kidney impairment.
CLARITHROMYCIN-500MGMyasthenia gravis and other myoneural disorders
Moderate
How does the disease interact with Synclar 500mg Infusion:
Myasthenia gravis symptoms have been observed to worsen and new myasthenic syndrome symptoms appear when macrolide antibiotics are used, according to reports. In patients who have a history of myasthenia gravis, therapy with these medicines should be used with caution.

How to manage the interaction:
Therapy should be administered cautiously in patients with a history of myasthenia gravis as the use of macrolide antibiotics has been reported to exacerbate symptoms of myasthenia gravis.
CLARITHROMYCIN-500MGAbnormal results of function studies
Moderate
How does the disease interact with Synclar 500mg Infusion:
Macrolides have been associated with an increase in the QT interval and occasional cases of arrhythmia. Patients with known QT interval prolongation, ventricular cardiac arrhythmia, including torsades de pointes, patients with proarrhythmic conditions like untreated hypokalemia or hypomagnesemia, clinically significant bradycardia, or patients taking other drugs that prolong the QT interval should avoid taking Synclar 500mg Infusion and erythromycin.

How to manage the interaction:
Synclar 500mg Infusion should be avoided in patients with known prolongation of the QT interval, abnormal heart rhythm, uncorrected low potassium or low magnesium, clinically significant slow heart rate, or receiving other drugs that prolong the QT interval.

FAQs

Drug-Drug Interactions Checker List

  • ERGOTAMINE
  • DIHYDROERGOTAMINE
  • TERFENADINE
  • ASTEMIZOLE
  • CISAPRIDE
  • DOMPERIDONE
  • PIMOZIDE
  • LOVASTATIN
  • SIMVASTATIN
  • LOMITAPIDE
  • ATORVASTATIN
  • MIDAZOLAM
  • COLCHICINE
  • TICAGRELOR
  • RANOLAZINE
  • ALPRAZOLAM
  • BUDESONIDE/FORMOTEROL

Special Advise

  • Synclar 500mg Infusion might affect blood and liver tests. Inform the person doing the tests that you are taking Synclar 500mg Infusion.

Disease/Condition Glossary

Bacterial infection: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. It can target any body part and multiply very quickly. When you get infected with bacteria, you can experience generalized symptoms like fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicines are more prone to bacterial infection.

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