SYNDOL MR TABLET belongs to the class of ‘analgesics’ used in treating acute musculoskeletal (bone, muscles, or ligaments) spasms associated with low back pain. Low back pain, also called lumbago, is a condition that affects the lower portion of the spine. It often occurs due to injury, strain, or sprain in the muscles, bones, or ligaments present in the lower back. In most cases, the only symptom of this condition is a pain in the lower back.

SYNDOL MR TABLET contains Eperisone and Diclofenac. Eperisone is an antispasmodic. It works by relaxing skeletal muscles and reducing myotonia (inability of muscles to relax). It can relax vascular smooth muscles (present in the blood vessels wall) to improve blood circulation. It can also suppress pain reflex. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing prostaglandins' production (chemical substances that cause pain and inflammation) at the affected site (muscle) and reduce pain.

You should use this medicine exactly as prescribed by the doctor. The common side-effects of SYNDOL MR TABLET are nausea, vomiting, stomach pain, heartburn, diarrhoea, indigestion, flatulence (gas), loss of appetite, headache, weakness, drowsiness, dizziness, and skin rash or spots. These side-effects are usually mild and temporary. However, if any of these side-effects persist or get worse, inform your doctor immediately.

It is not recommended to take SYNDOL MR TABLET if you are allergic to any contents of it. Before taking SYNDOL MR TABLET, inform your doctor if you have bleeding or ulcer in the stomach, history of stomach or bowel problems with NSAIDs, severe liver, kidney, heart failure, history of heart attack or stroke, and problems blood circulation. It is not recommended in children, pregnant women, and breastfeeding mothers. It should be used with caution in elderly patients. Avoid consumption of alcohol as it may increase the risk of side-effects. SYNDOL MR TABLET may cause dizziness or drowsiness, so do not drive or operate heavy machinery if you are not fully alert.

SYNDOL MR TABLET is used to treat pain associated with muscle spasms that usually occur due to muscle strains, sprains, or injuries in the lower back. It contains eperisone and diclofenac. Eperisone is a muscle relaxant that shows an analgesic effect (relieve pain), whereas diclofenac can reduce pain, swelling, and inflammation in the muscles. It provides fast relief from pain, within a few hours after taking this medicine. It reduces muscle stiffness and enables the easy movement of the muscle. It is also well tolerated when taken at recommended doses. For the best results, rest and physical therapy are also essential along with this medicine.

• Nausea
• Vomiting
• Stomach pain
• Heartburn
• Diarrhoea
• Indigestion
• Flatulence (gas)
• Loss of appetite
• Headache
• Weakness
• Drowsiness
• Dizziness
• Skin rash or spots

Before taking SYNDOL MR TABLET, inform your doctor if you have any bowel disorders such as colitis (inflammation of the intestine), kidney or liver problems, porphyria (inherited blood disorder), bleeding disorders, asthma, seasonal allergies, long-term respiratory infections or illnesses, angina (chest pain), blood clots, high blood pressure, high cholesterol, diabetes, systemic lupus erythematosus (a skin disorder), smoking habit, and intolerance to some sugars. SYNDOL MR TABLET increases the risk of heart attack or stroke if high doses are used for prolonged periods. So, use it in the dose and duration as prescribed by the doctor. If you notice chest pain, breathing difficulties, weakness, or slurry speech, inform your doctor immediately as it can be a sign of problems with heart or blood vessels. SYNDOL MR TABLET is an anti-inflammatory and can mask the symptoms of an infection, so consult your doctor if you feel unwell.

Drug-Drug Interactions: SYNDOL MR TABLET may interact with anticoagulant (warfarin), medications used to treat diabetes, an antidepressant (lithium), water pills, anticancer agent (methotrexate), medications that suppress the immune system (tacrolimus and ciclosporin), a medicine used to treat urinary tract infections (trimethoprim), quinolone antibiotics, other pain killers (aspirin and ibuprofen), a medication used to terminate the pregnancy (mifepristone), a medicine used to treat heart problems (digoxin), steroids, medications used to treat high blood pressure, a medication used to treat fungal infections (voriconazole), a medication used to treat fits (phenytoin), medications used to lower cholesterol levels (colestipol and cholestyramine), and a muscle relaxant (methocarbamol).

Drug-Food Interactions: Avoid the consumption of alcohol as it may increase dizziness and the risk of gastrointestinal bleeding.

Drug-Disease Interactions: SYNDOL MR TABLET should not be used in patients with bleeding or ulcer in the stomach, history of stomach or bowel problems with NSAIDs, severe liver, kidney, heart failure, heart attack history or stroke, and problems with blood circulation.

• WARFARIN
• LITHIUM
• METHOTREXATE
• TACROLIMUS
• CICLOSPORIN
• TRIMETHOPRIM
• ASPIRIN
• IBUPROFEN
• MIFEPRISTONE
• DIGOXIN
• VORICONAZOLE
• PHENYTOIN
• COLESTIPOL
• CHOLESTYRAMINE
• METHOCARBAMOL

• Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear, and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
• Deep tissue massages with the help of muscle massager are considered helpful.
• Avoid wearing tight-fitting clothes, instead, wear loose garments.
• Rest well and get optimal sleep (at least 8 hours for adults).
• Hot or cold therapy can help treat muscle spasms.
• Apply an ice-pack or hot-pack on the muscle for 15-20 minutes.
• Try to include glycine (protein) in your daily diet, which is good food for your muscle.

• Your doctor may advise you to undergo regular blood tests to monitor liver function while using SYNDOL MR TABLET if it is prescribed for longer durations.
• Take SYNDOL MR TABLET with food to minimize side-effects associated with stomach and intestine such as diarrhoea/upset stomach.

Low back pain: It is also called lumbago. It is a common condition that occurs due to injury, sprain, or strain to the muscles, bones, or ligaments present in the lower portion of the spine. The common causes are lack of regular exercise, improper postural lifting, bad or poor posture, and fracture. Pain in the lower back is the only symptom often seen with this condition. Analgesics (pain relievers) and physical therapy can help to relieve pain. Exercise helps in muscle stretching so that they are less likely to spasm, tear and sprain.