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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

TACROLIMUS-5MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Tacrotaj 5mg Capsule

Tacrotaj 5mg Capsule belongs to a class of drugs called immunosuppressants used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Tacrotaj 5mg Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. Thus, prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Take Tacrotaj 5mg Capsule as prescribed. You are advised to use Tacrotaj 5mg Capsule for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Tacrotaj 5mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Tacrotaj 5mg Capsule. Avoid alcohol consumption with Tacrotaj 5mg Capsule. Drive only if you are alert, as Tacrotaj 5mg Capsule may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Tacrotaj 5mg Capsule. Tacrotaj 5mg Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Tacrotaj 5mg Capsule

Prevent transplanted organ rejection

Directions for Use

Capsule: Take the capsule as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.Granules: The granules should be mixed with water to make an oral suspension. Drink the prepared suspension immediately. Do not save the suspension for later use.

Medicinal Benefits

Tacrotaj 5mg Capsule contains Tacrolimus, an immunosuppressant used to prevent organ rejection after a transplant. Tacrotaj 5mg Capsule suppresses the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tacrotaj 5mg Capsule
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Drug Warnings

Please tell your doctor if you are allergic to Tacrolimus or other medicines. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Tacrotaj 5mg Capsule. Avoid alcohol consumption with Tacrotaj 5mg Capsule. Drive only if you are alert, as Tacrotaj 5mg Capsule may cause vision problems or nervous disturbances in some people. If you are about to get vaccinated, inform your doctor before taking Tacrotaj 5mg Capsule. Tacrotaj 5mg Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system. While taking Tacrotaj 5mg Capsule, you are advised to wear protective clothing and sunscreen while going out. You are recommended to use glass or metal materials to prepare the oral suspension. Avoid using plastic (PVC) materials to prepare the suspension as the granules will stick to a plastic container, and your child may not receive their full dose. Do not inhale or let the granules or prepared oral suspension come in contact with your skin or eyes. In case of accidental contact with skin, wash the area well with soap and water, and if it comes in contact with the eyes, rinse with plain water.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Tacrotaj 5mg Capsule:
Taking Tacrotaj 5mg Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrotaj 5mg Capsule with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tacrotaj 5mg Capsule:
Combining Tacrotaj 5mg Capsule with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrotaj 5mg Capsule with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusSaquinavir
Critical
How does the drug interact with Tacrotaj 5mg Capsule:
Taking Tacrotaj 5mg Capsule with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrotaj 5mg Capsule with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tacrotaj 5mg Capsule:
Taking Tacrotaj 5mg Capsule with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrotaj 5mg Capsule with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tacrotaj 5mg Capsule:
Taking Tacrotaj 5mg Capsule with Mifepristone may significantly increase the blood levels of Tacrotaj 5mg Capsule, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Tacrotaj 5mg Capsule with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tacrotaj 5mg Capsule:
Taking cidofovir with Tacrotaj 5mg Capsule can increase the risk of kidney problems.

How to manage the interaction:
Taking Tacrotaj 5mg Capsule with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Tacrotaj 5mg Capsule:
Taking Tacrotaj 5mg Capsule with omeprazole may significantly increase the blood levels of Tacrotaj 5mg Capsule, which may increase the risk of serious side effects (high sugars, infections, kidney problems, hyperkalemia - high blood levels of potassium).

How to manage the interaction:
Although taking omeprazole with Tacrotaj 5mg Capsule can lead to interaction, they can be taken if recommended by a doctor. However, consult the doctor if you experience irregular heart rhythm, palpitations (fast heartbeat), muscle spasm, tremor (shaking of hands & legs), and seizures(fits). Do not stop using any medications without talking to a doctor.
How does the drug interact with Tacrotaj 5mg Capsule:
Taking leflunomide together with Tacrotaj 5mg Capsule may increase the risk of serious infections.

How to manage the interaction:
Although taking Tacrotaj 5mg Capsule and leflunomide together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
How does the drug interact with Tacrotaj 5mg Capsule:
Coadministration of Tacrotaj 5mg Capsule with amikacin can increase the risk of kidney problems.

How to manage the interaction:
Although taking amikacin and Tacrotaj 5mg Capsule together can result in an interaction but can be taken if a doctor has prescribed it. Consult the doctor if you experience vomiting, irregular urination, swelling, shortness of breath, muscle cramps, weakness, or palpitation. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Tacrotaj 5mg Capsule:
Taking Tacrotaj 5mg Capsule with posaconazole may significantly increase the blood levels of Tacrotaj 5mg Capsule, which may increase the risk of kidney problems, diabetes, hyperkalemia (high potassium levels in the blood), high blood pressure, irregular heart rhythm and infections.

How to manage the interaction:
Although using Posaconazole and Tacrotaj 5mg Capsule together can result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, red or irritated skin, body sores, discomfort or burning during urination, numbness or tingling, fits, dizziness, lightheadedness, fainting, and chest pain. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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TACROLIMUS-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TACROLIMUS-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Tacrotaj 5mg Capsule treatment may lead to increased Tacrotaj 5mg Capsule levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Tacrotaj 5mg Capsule.

Diet & Lifestyle Advise

Kidney transplant:

  • Include fruits and vegetables in your daily routine.
  • Follow a vitamin-C-rich diet.
  • Reduce salt intake.
  • Eat a handful of walnuts and almonds every day.
  • Reduce intake of unhealthy cholesterol and fats.
  • Consume dark chocolate with at least 70% cocoa.

Liver and Heart transplant:

  • Eat whole-grain bread, cereals and other grains, fruits and vegetables, lean meats, fish and poultry.
  • Maintain a low-fat and low-salt diet.
  • Drink low-fat milk or eat other low-fat dairy products to maintain adequate calcium.
  • Stay hydrated by drinking sufficient water and other fluids.
  • Avoid alcohol consumption.
  • Avoid grapefruit and grapefruit juice. 

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Drug-Drug Interactions Checker List

  • CYCLOSPORINE
  • SIROLIMUS
  • NELFINAVIR
  • PHENYTOIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • VORICONAZOLE
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • TRIAMTERENE
  • AMILORIDE

Special Advise

Regular blood tests and certain other tests are recommended while taking Tacrotaj 5mg Capsule to check blood sugar levels, kidney functioning and potassium levels in the blood.

Disease/Condition Glossary

Organ rejection: It occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it. Organ rejection may be hyperacute (occurs in minutes to hours), acute (occurs within the first few months), or chronic (occurs after a year or anytime beyond). The symptoms of organ rejection may vary based on the type of organ transplant you have had. However, if you experience pain, fever, or other signs of illness, contact your doctor immediately.

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