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  3. Tecentriq 1200 Injection 20 ml

Tecentriq 1200 Injection 20 ml, Pack of 1
Tecentriq 1200 Injection 20 ml, Pack of 1
Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Composition :

ATEZOLIZUMAB-60MG/ML

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Tecentriq 1200 Injection

Tecentriq 1200 Injection is an anti-cancer medicine used in the treatment of unresectable, stage II-IIIa non-small cell lung cancer (NSCLC). Tecentriq 1200 Injection is also used in combination with other cancer medicine for the treatment of metastatic NSCLC (bevacizumab, paclitaxel, carboplatin), extensive-stage small cell lung cancer and biliary tract cancer (carboplatin, etoposide), metastatic melanoma (cobimetinib, vemurafenib), and unresectable hepatocellular cancer (bevacizumab).

Tecentriq 1200 Injection contains Atezolizumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the action of a programmed death ligand receptor-1 (PD-L1), thereby stopping the abnormal growth of cancer cells.

Tecentriq 1200 Injection may cause certain side effects such as fatigue, cough, diarrhoea, nausea, vomiting, tiredness, itching, rash, headache, fever, shortness of breath, muscle/joint pain, abdominal pain, loss of appetite and injection site reactions. Inform your doctor if any of these side effects persist for longer. Tecentriq 1200 Injection will be administered by an oncologist trained in administering anti-cancer agents. 

Avoid receiving Tecentriq 1200 Injection and inform your doctor if you are allergic to it or any other components of it. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy. Avoid breastfeeding while taking this Tecentriq 1200 Injection. Before starting treatment with Tecentriq 1200 Injection, tell your doctor if you have/had liver or kidney disease, autoimmune disorders such as ulcerative colitis or Crohn's disease, a history of organ transplants, received an allogeneic stem cell transplant, or had radiation treatment to the chest, and myasthenia gravis.

Uses of Tecentriq 1200 Injection

Non-small cell lung cancer, Hepatocellular carcinoma, Biliary tract cancer, Small cell lung cancer, Metastatic melanoma.

Directions for Use

Tecentriq 1200 Injection will be administered by a trained oncologist in the hospital setting. Hence, do not self-administer. Your doctor will decide the dose and duration of the treatment based on the severity and type of cancer.

Medicinal Benefits

Tecentriq 1200 Injection contains Atezolizumab, which is used in the treatment of different types of cancers. It works by inhibiting the action of a programmed death ligand receptor-1 (PD-L1) that causes the multiplication of cancer cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other body parts.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tecentriq 1200 Injection 20 ml
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.

Drug Warnings

To treat your condition effectually, continue receiving Tecentriq 1200 Injection for the period that your doctor has prescribed. Tecentriq 1200 Injection may cause severe immune-mediated adverse reactions (IMAR) such as immune-mediated colitis, hepatitis, hepatotoxicity, nephritis, endocrinopathies, pneumonitis, cardiac problems, and dermatologic reactions. It may also cause infusion-related reactions in some patients. Therefore, caution should be exercised if you have/had liver or kidney disease, any history of organ transplant, gastrointestinal disorders, autoimmune disorders such as ulcerative colitis or Crohn’s disease, lung disease, heart problems, and breathing difficulty while receiving Tecentriq 1200 Injection. This medicine may also cause severe infusion-related reactions. Hence, careful monitoring is recommended and discontinue the treatment if any severe infusion reactions occur. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. This medicine is not recommended for use in children below 12 years of age as the safety and efficacy are not established.

Drug-Drug Interactions

verifiedApollotooltip
AtezolizumabTofacitinib
Severe
AtezolizumabPomalidomide
Severe

Drug-Drug Interactions

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AtezolizumabTofacitinib
Severe
How does the drug interact with Tecentriq 1200 Injection 20 ml:
Using tofacitinib together with Tecentriq 1200 Injection 20 ml may increase the risk of serious infections.

How to manage the interaction:
Although taking Tofacitinib and Tecentriq 1200 Injection 20 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. However consult your doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to your doctor.
AtezolizumabPomalidomide
Severe
How does the drug interact with Tecentriq 1200 Injection 20 ml:
Taking Tecentriq 1200 Injection 20 ml and Pomalidomide together may increase the risk of serious side effects.

How to manage the interaction:
Although taking Tecentriq 1200 Injection 20 ml and Pomalidomide together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
AtezolizumabLenalidomide
Severe
How does the drug interact with Tecentriq 1200 Injection 20 ml:
Using Tecentriq 1200 Injection 20 ml and Lenalidomide can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Tecentriq 1200 Injection 20 ml and Lenalidomide, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
AtezolizumabLeflunomide
Severe
How does the drug interact with Tecentriq 1200 Injection 20 ml:
Taking leflunomide with Tecentriq 1200 Injection 20 ml may raise the risk of severe infections.

How to manage the interaction:
Although there is an interaction between leflunomide and Tecentriq 1200 Injection 20 ml, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
AtezolizumabBaricitinib
Severe
How does the drug interact with Tecentriq 1200 Injection 20 ml:
Combining Tecentriq 1200 Injection 20 ml with Baricitinib can increase the risk of developing a serious infection.

How to manage the interaction:
Taking Tecentriq 1200 Injection 20 ml with Baricitinib together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
AtezolizumabEtanercept
Severe
How does the drug interact with Tecentriq 1200 Injection 20 ml:
When Tecentriq 1200 Injection 20 ml is taken with Etanercept, the chance or severity of infection might be enhanced.

How to manage the interaction:
Although there is a possible interaction between Etanercept and Tecentriq 1200 Injection 20 ml, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AtezolizumabCladribine
Severe
How does the drug interact with Tecentriq 1200 Injection 20 ml:
The combined use of Tecentriq 1200 Injection 20 ml with cladribine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Tecentriq 1200 Injection 20 ml with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, contact a doctor right away. Do not stop using any medications without talking to a doctor.
AtezolizumabThalidomide
Severe
How does the drug interact with Tecentriq 1200 Injection 20 ml:
Taking thalidomide with Tecentriq 1200 Injection 20 ml may increase the risk of serious side effects.

How to manage the interaction:
Taking Thalidomide with Tecentriq 1200 Injection 20 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual symptoms, you should consult a doctor immediately. Do not stop using any medications without consulting your doctor.
AtezolizumabInfliximab
Severe
How does the drug interact with Tecentriq 1200 Injection 20 ml:
Combining Infliximab with Tecentriq 1200 Injection 20 ml can increase the risk or severity of developing infections.

How to manage the interaction:
Co-administration of Tecentriq 1200 Injection 20 ml with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, aids in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep while resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants, such as berries, spinach, etc.
  • Foods containing fibre help with digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Author Details

Lakshmithulasi YarraguntaDoctor badge

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 20, 2024 | 1:18 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Tecentriq 1200 Injection contains Atezolizumab, which works by inhibiting the action of a programmed death receptor-1 (PD-L1) that causes the multiplication of cancerous cells.

Drug-Drug Interactions Checker List

  • THALIDOMIDE
  • PREDNISOLONE
  • METHYLPREDNISOLONE

Special Advise

  • Your doctor may suggest periodic liver function tests, kidney function tests, and lung function tests to monitor the function of the liver, kidney and lungs due to the use of Tecentriq 1200 Injection.
  • Using contraceptive pills while using Tecentriq 1200 Injection to prevent pregnancy is advised.
  • Thyroid function and adrenocorticotropic hormone levels will be monitored during treatment to avoid any life-threatening side effects.

Disease/Condition Glossary

Non-Small Cell Lung Cancer (NSCLC): It is the most common form of lung cancer, which occurs when cells that form the lining of the lung start growing uncontrollably. It is mostly seen in persons who smoke. Symptoms may include chest pain, weight loss, hoarseness, and difficulty breathing.

Hepatocellular carcinoma: It occurs when the cancer/ malignant cells grow out of control in the liver. This infects the liver, destroys the liver cells and affects the ability of the liver to work properly. Symptoms may include abdominal pain, loss of appetite, weight loss, and pale bowel motions.

Biliary tract cancer: Also known as bile duct cancer or Cholangiocarcinoma. It is a rare type of cancer in which the cancer cells grow abnormally in the epithelial cells lining the biliary tract. Symptoms may include abdominal pain, itching, fever, weight loss, changes in the colour of urine and stools, and jaundice.

Metastatic Malignant Melanoma: Melanoma is a type of skin cancer in which the cancer cells grow in melanocytes. It is mainly caused by harmful UV radiation from the sun. Malignant melanoma is common in fair-skinned and freckled individuals. It results in mole formation, typically on the skin of the face. Tecentriq 1200 Injection is used in combination with ipilimumab in adults and children above 12 years of age.

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