THEMISET 75/1.5MG INJECTION

Written By Veda Maddala , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹218

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Whats That

About THEMISET 75/1.5MG INJECTION

THEMISET 75/1.5MG INJECTION belongs to a class of drugs called antiemetics used to prevent nausea and vomiting during chemotherapy. Nausea is a feeling of uneasiness of the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

THEMISET 75/1.5MG INJECTION contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

THEMISET 75/1.5MG INJECTION will be administered by a healthcare professional; do not self-administer. In some cases, you may experience diarrhoea, constipation, dizziness or headache. Most of these side effects of THEMISET 75/1.5MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to THEMISET 75/1.5MG INJECTION or any other medicines, please tell your doctor. THEMISET 75/1.5MG INJECTION may be given to children above 1 month in doses as advised by a doctor based on the child's body weight. If you are pregnant or breastfeeding, please inform your doctor before taking THEMISET 75/1.5MG INJECTION. Drive only if you are alert as THEMISET 75/1.5MG INJECTION may cause tiredness or dizziness. You are recommended to avoid heavy meals and take small nourishing snacks throughout the day. Drink plenty of water to avoid dehydration.

Uses of THEMISET 75/1.5MG INJECTION

Nausea and vomiting

Directions for Use

THEMISET 75/1.5MG INJECTION will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

THEMISET 75/1.5MG INJECTION contains Palonosetron which blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting during chemotherapy.

Storage

Keep THEMISET 75/1.5MG INJECTION out of reach and sight of children.

Side effects of Themiset 75/1.5mg Injection

Anxiety

Managing Medication-Triggered Anxiety: A Comprehensive Approach:

Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Weakness

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Itching

Here are the few steps for dealing with itching caused by drug use:

Report the itching to your doctor immediately; they may need to change your medication or dosage.
Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
Try not to scratch, as this can worsen the itching and irritate your skin.
If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Drug Warnings

If you are allergic to THEMISET 75/1.5MG INJECTION or any other medicines, please tell your doctor. THEMISET 75/1.5MG INJECTION may be given to children above 1 month in doses as advised by a doctor based on the child's body weight. If you are pregnant or breastfeeding, please inform your doctor before taking THEMISET 75/1.5MG INJECTION. Drive only if you are alert as THEMISET 75/1.5MG INJECTION may cause tiredness or dizziness. You are recommended to avoid heavy meals and take small nourishing snacks throughout the day. Drink plenty of water to avoid dehydration.

Drug-Drug Interactions

PalonosetronZiprasidone

Critical

PalonosetronCeritinib

Severe

Drug-Drug Interactions

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PalonosetronZiprasidone

Critical

How does the drug interact with Themiset 75/1.5mg Injection:
Combining Themiset 75/1.5mg Injection with Ziprasidone can increase the risk of side effects.

How to manage the interaction:
Taking Ziprasidone with Themiset 75/1.5mg Injection is not recommended, please consult your doctor before taking it.

PalonosetronCeritinib

Severe

How does the drug interact with Themiset 75/1.5mg Injection:
Taking Ceritinib with Themiset 75/1.5mg Injection can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Ceritinib and Themiset 75/1.5mg Injection together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

PalonosetronLinezolid

Severe

How does the drug interact with Themiset 75/1.5mg Injection:
When linezolid is taken with Themiset 75/1.5mg Injection it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of linezolid along with Themiset 75/1.5mg Injection can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.

PalonosetronAmiodarone

Severe

How does the drug interact with Themiset 75/1.5mg Injection:
Coadministration of Amiodarone with Themiset 75/1.5mg Injection can lead to or increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Amiodarone with Themiset 75/1.5mg Injection together is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

PalonosetronAmitriptyline

Severe

How does the drug interact with Themiset 75/1.5mg Injection:
Combining Themiset 75/1.5mg Injection with Amitriptyline can increase the risk of serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although using Themiset 75/1.5mg Injection and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.

PalonosetronParoxetine

Severe

How does the drug interact with Themiset 75/1.5mg Injection:
Using Themiset 75/1.5mg Injection together with paroxetine can increase the risk of condition called the serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Paroxetine with Themiset 75/1.5mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, diarrhea, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

PalonosetronDextromethorphan

Severe

How does the drug interact with Themiset 75/1.5mg Injection:
Co-administration of Dextromethorphan and Themiset 75/1.5mg Injection may increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although there is a possible interaction between Dextromethorphan and Themiset 75/1.5mg Injection, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as seizures (fits), extreme changes in blood pressure, confusion, hallucination, increased heart rate, fever, excessive sweating, shivering or shaking, tremors, incoordination, blurred vision, muscle spasms or stiffness, nausea, vomiting, stomach cramp, and diarrhea, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.

PalonosetronClomipramine

Severe

How does the drug interact with Themiset 75/1.5mg Injection:
The combined use of Themiset 75/1.5mg Injection with clomipramine can increase the risk of serotonin syndrome (Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhea) to severe (muscle rigidity, fever, and seizures)).

How to manage the interaction:
Although taking clomipramine and Themiset 75/1.5mg Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor.

PalonosetronFentanyl

Severe

How does the drug interact with Themiset 75/1.5mg Injection:
Taking fentanyl with Themiset 75/1.5mg Injection may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Fentanyl with Themiset 75/1.5mg Injection can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience confusion, hallucinations (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain or stiffness, stomach cramps, vomiting, or diarrhoea, consult a doctor. Do not discontinue any medications without consulting your doctor.

PalonosetronBuspirone

Severe

How does the drug interact with Themiset 75/1.5mg Injection:
Using Buspirone together with Fenfluramine can increase the risk of a serious condition called serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a chemical that plays a role in overall wellbeing and especially a mood stabilizer).

How to manage the interaction:
Co- administration of buspirone along with Themiset 75/1.5mg Injection can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
Also, if you like to vomit at a specific time, avoid eating your favourite food at that particular time as your taste for that food may get turned off.
Drink any other liquid at least 30 minutes after eating food.
If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Side Effects of THEMISET 75/1.5MG INJECTION

Diarrhoea
Constipation
Dizziness
Headache

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:47 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does THEMISET 75/1.5MG INJECTION work?

THEMISET 75/1.5MG INJECTION contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

Can I take erythromycin with THEMISET 75/1.5MG INJECTION?

You are not recommended to take erythromycin with THEMISET 75/1.5MG INJECTION as it may increase the risk of severe irregular heart rhythm. However, please consult your doctor before taking other medicines with THEMISET 75/1.5MG INJECTION.

Does THEMISET 75/1.5MG INJECTION cause constipation?

THEMISET 75/1.5MG INJECTION may cause constipation as a side effect. It is not necessary for everyone taking THEMISET 75/1.5MG INJECTION to experience this side effect. However, if the condition persists or worsens, please consult a doctor.

Is THEMISET 75/1.5MG INJECTION safe for patients suffering from heart problems?

THEMISET 75/1.5MG INJECTION should be used with caution in patients suffering from heart problems as it may worsen the condition. Therefore, inform your doctor if you have any heart problems before taking have THEMISET 75/1.5MG INJECTION so that the dose may be adjusted appropriately.

Drug-Drug Interactions Checker List

CITALOPRAM
FLUVOXAMINE
PAROXETINE
SERTRALINE
ESCITALOPRAM
DULOXETINE
VENLAFAXINE
QUINIDINE
AMIODARONE
NICARDIPINE
MOXIFLOXACIN
ERYTHROMYCIN
DOMPERIDONE
THIORIDAZINE
QUETIAPINE
CHLORPROMAZINE
HALOPERIDOL

Disease/Condition Glossary

Nausea and vomiting: Nausea is a feeling of uneasiness of the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth. In short, nausea and vomiting are not diseases but are symptoms of many conditions like infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). There is a receptor located in our brain known as the chemoreceptor zone (CTZ) that controls vomiting.