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Written By Divya L , PharmaD
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Composition :

NEOSTIGMINE-15MG

Manufacturer/Marketer :

Tablets India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tilstigmin Tablet

Tilstigmin Tablet belongs to a group of medicines called 'anticholinesterase agents/acetylcholinesterase inhibitors,' primarily used to treat myasthenia gravis. Tilstigmin Tablet is also used when the normal movements of the intestine are absent and to treat post-operative urinary retention.

Tilstigmin Tablet contains 'Neostigmine.' It increases levels of a neurotransmitter called acetylcholine by stopping the excess cholinesterase activity (an enzyme required to break down acetylcholine) involved in communication between nerve impulses and muscle movements. Neurotransmitters are chemical messengers that transmit the message from one nerve cell to another nerve cell, muscle cell, or gland cell. Thus Tilstigmin Tablet helps in proper muscle functioning and prevents muscle weakness.

Take this medicine as prescribed by your doctor. In some cases, you may experience common side effects, such as nausea, vomiting, abdominal cramps, diarrhoea, increased saliva production, dizziness, headache, trouble sleeping, and dry mouth. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Inform your doctor before using Tilstigmin Tablet if you have a history of liver, heart or kidney diseases, asthma, stomach ulcer, fits, Parkinson’s disease, overactive thyroid, and irritability of the vagus nerve (connects to the abdomen from the brain) that causes excess bowel contractions. Before starting this medicine, you must let your doctor know if you are pregnant, planning to conceive, or a breastfeeding mother. Avoid consuming alcohol during the course to prevent unwanted side effects. Tilstigmin Tablet can be given to children if prescribed by the doctor; the dose depends on the child’s age and weight.

Uses of Tilstigmin Tablet

Myasthenia gravis and post-operative urinary retention.

Directions for Use

Swallow it as a whole with a glass of water. Do not chew, crush or break it.

Medicinal Benefits

Tilstigmin Tablet belongs to the group of medicines called 'anticholinesterase agents/cholinesterase inhibitors and is used to treat myasthenia gravis (muscle weakness). Tilstigmin Tablet contains 'Neostigmine'. It works by stopping the excessive activity of cholinesterase, helping the muscles work correctly. Additionally, Tilstigmin Tablet is used to treat urinary retention and reverses the effects of neuromuscular blocking agents (tubocurarine, metocurine, gallamine or pancuronium) after surgery. Neostigmine affects the body's chemicals, which are involved in communication between nerve impulses and muscle movements. Thereby, Tilstigmin Tablet treats associated muscle disorders by improving muscle strength.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Brief your medical history if you have any liver or kidney diseases, heart diseases (coronary artery disease, irregular heartbeat), asthma, stomach ulcer, fits, urination problems, Parkinson's disease, overactive thyroid, and irritability of vagus nerve (connects to the abdomen from the brain) that causes excess bowel contractions before starting Tilstigmin Tablet . Please consult your doctor if you are pregnant, planning to conceive, or are a breastfeeding mother. Avoid consuming alcohol with Tilstigmin Tablet to get the maximum benefits of the medicine and prevent the aggravation of the disease. Drive or operate machinery only when you are alert and focused during the course.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Tilstigmin Tablet:
Co-administration of tramadol with Tilstigmin Tablet can increase the effect of tramadol.

How to manage the interaction:
Taking Tilstigmin Tablet with tramadol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain proper weight by following a healthy diet.
  • Avoid smoking and alcohol consumption.
  • Try to avoid stress by practising meditation or yoga.
  • Include fruits and vegetables in your diet as they contain antioxidants.
  • Eat warm meals rather than hot meals, as heat aggravates the disease.
  • Try sipping a cold drink while having hot or warm meals.
  • Avoid foods that require a lot of chewing, like tough meats.
  • Exercise regularly to keep your muscles strong
  • Limit foods with high cholesterol and saturated fats.
  • Cut down on sugar, salt and processed foods.
  • Drink plenty of water.

Habit Forming

No

Therapeutic Class

MUSCLE STIMULANTS AND CHOLINESTERASE INHIBITORS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Tilstigmin Tablet works by stopping the excessive cholinesterase activity (an enzyme necessary for the breakdown of a neurotransmitter called acetylcholine) involved in communication between nerve impulses and muscle movements. Thereby, Tilstigmin Tablet helps in proper muscle functioning and prevents muscle weakness.

Tilstigmin Tablet should be used with caution in the medical history of liver or kidney diseases, heart diseases (coronary artery disease, irregular heartbeat), chronic obstructive pulmonary disease, asthma, stomach ulcer, fits, urination problems, Parkinson's disease, overactive thyroid (hypothyroidism), and irritability of vagus nerve (connects to the abdomen from the brain) that causes excess bowel contractions. Please let your doctor know if you have any other medical problems before starting.

Do not stop taking Tilstigmin Tablet on your own. Please continue taking Tilstigmin Tablet for the prescribed period to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Tilstigmin Tablet .

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.

Keep Tilstigmin Tablet in a cool, dry place away from direct sunlight. Dispose of unused medicine and keep it out of sight and reach from children and pets.

Drug-Drug Interactions Checker List

  • HALOTHANE
  • CYCLOPROPANE
  • SUCCINYLCHOLINE
  • SUXAMETHONIUM
  • NEOMYCIN
  • STREPTOMYCIN
  • AMIFAMPRIDINE
  • BUPROPION
  • DONEPEZIL

Special Advise

Tilstigmin Tablet might interfere with the effects of skeletal muscle relaxants used in the surgery.

Disease/Condition Glossary

Myasthenia gravis: It is an autoimmune neuromuscular disease that causes skeletal muscle weakness. The immune system mistakenly attacks its own healthy tissues, damaging the neuromuscular membrane. This reduces the effect of acetylcholine, a neurotransmitter that plays a major role in the communication between nerve cells and muscles. Myasthenia gravis occurs when the communication between nerve cells and muscles becomes impaired. This prevents muscle contractions, thereby leading to muscle weakness. The most affected muscles are those of the face and eyes. Symptoms of myasthenia gravis include double vision, drooping eyelids, difficulty chewing or swallowing, weakness, problems with lifting objects, and trouble talking and walking.

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