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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
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Whats That

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Composition :

TOFACITINIB-11MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tofatas XR 11 mg Tablet

Tofatas XR 11 mg Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is an inflammatory condition of the joints, often associated with psoriasis. Ulcerative colitis is an inflammatory disease of the large intestine.
 
Tofatas XR 11 mg Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
 
In some cases, you may experience common side-effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofatas XR 11 mg Tablet if you are pregnant or breastfeeding. Tofatas XR 11 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Tofatas XR 11 mg Tablet

Rheumatoid arthritis, Psoriatic arthritis, Ulcerative colitis.

Directions for Use

Swallow Tofatas XR 11 mg Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Tofatas XR 11 mg Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Tofatas XR 11 mg Tablet works by blocking Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. Tofatas XR 11 mg Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

Storage

Store in a cool and dry place away from sunlight
Side effects of Tofatas XR 11 mg Tablet
  • Practice good hygiene by washing hands frequently when touching any wounds.
  • Apply creams or lotions to the dry skin and moisturize it.
  • Wear the proper clothing and footwear when working outside.
  • Cover the wounds with bandage and change it daily.
  • Avoid baths at swimming pools, lakes and rivers.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Drink a lot of water to control diarrhoea and prevent dehydration.
  • Avoid spicy, fatty, or high-fiber foods that may irritate the colon.
  • Reduce stress through methods such as deep breathing or meditation.
  • Include probiotics or supplements containing live bacteria to maintain the health of the gut.
  • Quit smoking since smoking makes colitis symptoms worse.
  • See your doctor right away if you experience extreme inflammation, bleeding stools, or abdominal pain.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • To promote overall health, drink plenty of water and consume hydrating foods like watermelon and leafy greens.
  • Support gut health with probiotic-rich foods such as yoghurt and sauerkraut.
  • Eat antioxidant-rich foods like berries and green tea, while limiting sugary drinks, alcohol, and processed foods.
  • Additionally, reduce stress through relaxation techniques like deep breathing and meditation.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Drug Warnings

Do not take Tofatas XR 11 mg Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, active tuberculosis, or if you have severe liver problems such as cirrhosis. Avoid taking Tofatas XR 11 mg Tablet if you are pregnant or breastfeeding. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, or were in close contact with someone who has/had tuberculosis; chronic lung disease, liver problems, hepatitis B/C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney problems, planning to get vaccinated, heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking Tofatas XR 11 mg Tablet . Tofatas XR 11 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Tofatas XR 11 mg Tablet:
Taking Tofatas XR 11 mg Tablet with Cladribine may increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladribine and Tofatas XR 11 mg Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tofatas XR 11 mg Tablet:
Using Tofatas XR 11 mg Tablet together with adalimumab can increase the risk of serious infections

How to manage the interaction:
Although taking Tofatas XR 11 mg Tablet and Adalimumab together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tofatas XR 11 mg Tablet:
Combining Infliximab with Tofatas XR 11 mg Tablet can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Although taking Tofatas XR 11 mg Tablet and Infliximab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tofatas XR 11 mg Tablet:
When Tofatas XR 11 mg Tablet is taken with Daunorubicin, it may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofatas XR 11 mg Tablet and Daunorubicin, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Tofatas XR 11 mg Tablet:
Posaconazole can raise the levels of Tofatas XR 11 mg Tablet in the bloodstream. You may experience increased side effects, including low blood cell counts, anemia, severe infections, and elevated blood lipid levels.

How to manage the interaction:
Although using Posaconazole and Tofatas XR 11 mg Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience any side effects of Tofatas XR 11 mg Tablet, such as exhaustion, dizziness, fainting, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Tofatas XR 11 mg Tablet:
Taking Dacarbazine with Tofatas XR 11 mg Tablet may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Dacarbazine and Tofatas XR 11 mg Tablet, but it can be taken if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tofatas XR 11 mg Tablet:
Using Tofatas XR 11 mg Tablet together with bendamustine may increase the risk of developing serious infections.

How to manage the interaction:
Taking Tofatas XR 11 mg Tablet with Bendamustine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tofatas XR 11 mg Tablet:
When Tofatas XR 11 mg Tablet is taken with Vinblastine it may increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Vinblastine and Tofatas XR 11 mg Tablet, but it can be taken if prescribed by a doctor. It is important to keep a close eye on your symptoms. If you notice any of the following - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating - make sure to contact your doctor right away. They will be able to help you and provide the necessary care. Do not discontinue any medications without first consulting your doctor.
TofacitinibPralatrexate
Severe
How does the drug interact with Tofatas XR 11 mg Tablet:
Taking Tofatas XR 11 mg Tablet with Pralatrexate may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Pralatrexate and Tofatas XR 11 mg Tablet, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tofatas XR 11 mg Tablet:
Co-administration of Tofatas XR 11 mg Tablet with Capecitabine may increase the risk of serious and potential infections.

How to manage the interaction:
Although there is an interaction, Capecitabine can be taken with Tofatas XR 11 mg Tablet if prescribed by the doctor. Consult the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Tofatas XR 11 mg Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Tofatas XR 11 mg Tablet, as it can lead to an interaction.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Tofatas XR 11 mg Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of Tofatas XR 11 mg Tablet . Consult your doctor before taking Tofatas XR 11 mg Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of Tofatas XR 11 mg Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Tofatas XR 11 mg Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofatas XR 11 mg Tablet if you are trying to become pregnant or if you have any concerns regarding this.

Tofatas XR 11 mg Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.

Drug-Drug Interactions Checker List

  • RIFAMPICIN
  • FLUCONAZOLE
  • KETOCONAZOLE
  • AZATHIOPRINE
  • MERCAPTOPURINE
  • CYCLOSPORINE
  • TACROLIMUS
  • PREDNISONE

Special Advise

  • Your doctor may advise you to get a blood test done before starting treatment with Tofatas XR 11 mg Tablet , after 4-8weeks of treatment and then every three months to determine your blood cell count.
  • Your doctor might advise regular tests to determine blood cholesterol levels and liver functioning.
  • Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties.
  • If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofatas XR 11 mg Tablet and for 4 weeks after discontinuation.

Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those who have relatives with psoriasis. It affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

Ulcerative colitis: It is a type of chronic inflammatory bowel disease that causes inflammation of the lining of the large intestine (colon) and produces ulcers on the lining of the colon, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever, and weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite or nausea. 

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