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  3. Tolaz LA 405mg/vial Convenience Kit 1's

Tolaz LA 405mg/vial Convenience Kit 1's, Pack of 1 INJECTION
Tolaz LA 405mg/vial Convenience Kit 1's, Pack of 1 INJECTION
Tolaz LA 405mg/vial Convenience Kit 1's, Pack of 1 INJECTION
Tolaz LA 405mg/vial Convenience Kit 1's, Pack of 1 INJECTION
Written By Divya L , PharmaD
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Composition :

OLANZAPINE-405MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Tolaz LA 405mg/vial Convenience Kit

Tolaz LA 405mg/vial Convenience Kit belongs to a group of medicines called 'atypical antipsychotics,' primarily used to treat schizophrenia and manic or mixed episodes of bipolar I disorder. Schizophrenia is a mental condition in which you may feel, hear or see things that are not there (hallucinations), believe things that are not true, and feel unusually suspicious or confused. Bipolar I disorder is a serious brain disorder where you experience extreme mood swings (variance in thinking) and frequent mood and behaviour changes.

Tolaz LA 405mg/vial Convenience Kit contains 'Olanzapine' that works by restoring the balance of chemical messengers in the brain and improves thinking mood, and behaviour. Tolaz LA 405mg/vial Convenience Kit improves mental clarity and lessens hallucinations. It is used to treat schizophrenia-related agitation and the manic phases of bipolar disorder.

Tolaz LA 405mg/vial Convenience Kit will be administered by a health care professional; do not self-administer. Common side effects include drowsiness, dizziness, headache, dry mouth, nausea, vomiting, diarrhoea, constipation, stomach pain, back pain, runny/stuffy nose, cough, increased appetite, weight gain, and redness/pain/swelling at the injection site. These side effects are not common for everyone. If you notice any side effects that are not manageable, please consult your doctor. 

Tolaz LA 405mg/vial Convenience Kit is not recommended for treatment in patients with Dementia-Related Psychosis. Inform your doctor beforehand if you have a history of allergic reactions to Olanzapine, Alzheimer's disease, liver or kidney diseases, heart problems, breathing problems, high cholesterol, glaucoma, diabetes, breast cancer, enlarged prostate, and fits before taking this medicine. If you are pregnant, planning to conceive, or breastfeeding, inform your doctor before receiving Tolaz LA 405mg/vial Convenience Kit. Avoid consuming alcohol along with Tolaz LA 405mg/vial Convenience Kit as it can make you dizzy or drowsy. Do not drive or operate machinery after using Tolaz LA 405mg/vial Convenience Kit since it can make you sleepy. Olanzapine is not recommended for children and adolescents below 18 years of age; however, please seek medical advice.

Uses of Tolaz LA 405mg/vial Convenience Kit

Schizophrenia and bipolar I disorder.

Directions for Use

It will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Tolaz LA 405mg/vial Convenience Kit is used to treat manic episodes of bipolar I disorder and agitation in schizophrenia. It contains 'Olanzapine,' which belongs to the class of atypical antipsychotics. It works by restoring the balance of chemical messengers in the brain. It is also known to improve thinking, mood, and behaviour. It helps in clear thinking and relieves psychotic symptoms like hallucinations.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tolaz LA 405mg/vial Convenience Kit
  • Exercise for at least 30 minutes most days of the week.
  • Limit alcohol consumption.
  • Consider a low carbohydrate diet that limits grains, starchy vegetables and fruit. Include foods rich in protein and fat.
  • Avoid excess sugar, fatty foods and carbohydrates.
  • Aim for weight loss as it helps to improve cardiovascular health and minimize the risk of complications related to obesity.
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Discuss with your doctor if you suspect a medicine is causing hyperprolactinemia. Your doctor may reduce the dose or switch to an alternative medicine with low impact on prolactin levels.
  • Assess the severity of your symptoms related to high prolactin levels, like sexual dysfunction in men and menstrual irregularities in women for treatment choices.
  • Regular blood tests are recommended to monitor prolactin levels to assess treatment effectiveness.

Drug Warnings

Tolaz LA 405mg/vial Convenience Kit is not recommended for use in patients with Dementia-Related Psychosis. Brief your medical history to the doctor if you have any allergic reactions, liver or kidney diseases, Alzheimer's disease, dementia, heart problems, breathing problems, high cholesterol, glaucoma, diabetes, bowel problems, sleep apnea, low white blood cell count, breast cancer, enlarged prostate, or fits before starting Tolaz LA 405mg/vial Convenience Kit. Please inform your doctor if you are pregnant or planning to conceive before starting this medicine. Tolaz LA 405mg/vial Convenience Kit is not recommended during breastfeeding. Avoid consuming alcohol as it might lead to increased side effects like dizziness and drowsiness. Avoid driving or operating machinery as Tolaz LA 405mg/vial Convenience Kit may decrease your mental alertness, making you feel dizzy or drowsy. Tolaz LA 405mg/vial Convenience Kit is not recommended for people below 18 years of age as safety and effectiveness have not been established.

Drug-Drug Interactions

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OlanzapineRopinirole
Critical
OlanzapinePotassium citrate
Critical

Drug-Drug Interactions

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OlanzapineRopinirole
Critical
How does the drug interact with Tolaz LA 405mg/vial Convenience Kit:
When Ropinirole is taken with Tolaz LA 405mg/vial Convenience Kit, it may reduce the effectiveness of ropinirole.

How to manage the interaction:
Taking Ropinirole with Tolaz LA 405mg/vial Convenience Kit is not recommended as it can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as drowsiness, low blood pressure, dizziness, and lightheadedness. Do not stop using any medications without consulting doctor.
OlanzapinePotassium citrate
Critical
How does the drug interact with Tolaz LA 405mg/vial Convenience Kit:
Taking Tolaz LA 405mg/vial Convenience Kit with Potassium citrate can increase the irritant effects of potassium on your stomach and upper intestine.

How to manage the interaction:
Co-administration of Tolaz LA 405mg/vial Convenience Kit and Potassium citrate is not recommended as it leads to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OlanzapinePramipexole
Critical
How does the drug interact with Tolaz LA 405mg/vial Convenience Kit:
Taking Tolaz LA 405mg/vial Convenience Kit with Pramipexole can increase the risk and severity of side effects and reduce the effectiveness of Pramipexole.

How to manage the interaction:
Co-administration of Tolaz LA 405mg/vial Convenience Kit and Pramipexole is not recommended as it leads to an interaction, it can be taken if advised by a doctor. If you experience any symptoms such as drowsiness, dizziness, and lightheadedness, contact a doctor immediately. Avoid driving or operating dangerous machinery, and be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
OlanzapinePotassium chloride
Critical
How does the drug interact with Tolaz LA 405mg/vial Convenience Kit:
Taking Tolaz LA 405mg/vial Convenience Kit with Potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Co-administration of Tolaz LA 405mg/vial Convenience Kit and Potassium chloride is not recommended as it leads to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OlanzapineSodium oxybate
Severe
How does the drug interact with Tolaz LA 405mg/vial Convenience Kit:
Using sodium oxybate together with Tolaz LA 405mg/vial Convenience Kit may increase side effects such as drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination.

How to manage the interaction:
Co-administration of sodium oxybate and Tolaz LA 405mg/vial Convenience Kit can lead to an interaction, it can be taken if advised by your doctor. If you experience any symptoms, contact your doctor immediately. Avoid driving, operating machinery, or engaging in potentially hazardous activities requiring mental alertness and motor coordination for at least six hours after taking sodium oxybate and until you know how the medications affect you, and use caution when getting up from a sitting or lying position. Do not discontinue any medications without first consulting your doctor.
OlanzapineMidazolam
Severe
How does the drug interact with Tolaz LA 405mg/vial Convenience Kit:
When used together, Midazolam and Tolaz LA 405mg/vial Convenience Kit can cause low blood pressure, shallow breathing, weak pulse, muscle weakness, drowsiness, dizziness and slurred speech.

How to manage the interaction:
Combining of Tolaz LA 405mg/vial Convenience Kit and Midazolam can lead to an interaction, it can be taken if your doctor has suggested it. If you experience any symptoms consult the doctor immediately. Avoid activities requiring mental alertness until you know how these medications will affect you and do not discontinue any medications without consulting a doctor.
OlanzapineHydromorphone
Severe
How does the drug interact with Tolaz LA 405mg/vial Convenience Kit:
Combining Tolaz LA 405mg/vial Convenience Kit with Hydromorphone can cause central nervous system depression such as Tolaz LA 405mg/vial Convenience Kit can lead to serious side effects including respiratory distress, intestinal obstruction, fecal impaction.

How to manage the interaction:
Although taking Tolaz LA 405mg/vial Convenience Kit and Hydromorphone together can lead to an interaction, it can be taken if your doctor has suggested it. If you experience any symptoms like feeling tired, having trouble breathing, feeling dizzy or drowsy, difficulty focusing, taking pain or cough medications, constipation, blockage in your intestines, difficulty passing stool, hard or dry stool, less frequent bowel movements, stomach problems, feeling sick, feeling bloated, having stomach pain, or swelling contact the doctor immediately. you should avoid driving or operating hazardous machinery until you know how they affect you and do not discontinue any medications without consulting your doctor.
OlanzapineDiazepam
Severe
How does the drug interact with Tolaz LA 405mg/vial Convenience Kit:
Taking diazepam together with Tolaz LA 405mg/vial Convenience Kit can cause low blood pressure, weak pulse, shallow breathing, muscle weakness, drowsiness, dizziness and slurred speech.

How to manage the interaction:
Combining Tolaz LA 405mg/vial Convenience Kit and Diazepam can lead to an interaction, it can be taken if your doctor has suggested it. If you experience any symptoms consult the doctor immediately. Avoid activities requiring mental alertness until you know how these medications will affect you. Do not stop using any medications without first talking to your doctor.
OlanzapineFentanyl
Severe
How does the drug interact with Tolaz LA 405mg/vial Convenience Kit:
Taking Tolaz LA 405mg/vial Convenience Kit with fentanyl can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Tolaz LA 405mg/vial Convenience Kit and fentanyl, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sleepiness, difficulty concentrating, and impaired judgment. Do not discontinue any medications without consulting a doctor.
OlanzapineNalbuphine
Severe
How does the drug interact with Tolaz LA 405mg/vial Convenience Kit:
Combining Tolaz LA 405mg/vial Convenience Kit with Nalbuphine can cause central nervous system depression such as Tolaz LA 405mg/vial Convenience Kit can lead to serious side effects including respiratory distress, intestinal obstruction, fecal impaction.

How to manage the interaction:
Although taking Tolaz LA 405mg/vial Convenience Kit and Nalbuphine together can lead to an interaction, it can be taken if your doctor has suggested it. If you experience any symptoms like feeling tired, having trouble breathing, feeling dizzy or drowsy, difficulty focusing, taking pain or cough medications, constipation, blockage in your intestines, difficulty passing stool, hard or dry stool, less frequent bowel movements, stomach problems, feeling sick, feeling bloated, having stomach pain, or swelling contact the doctor immediately. you should avoid driving or operating hazardous machinery until you know how they affect you and do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain proper weight by following a healthy diet.
  • Exercise regularly as it helps in less cognitive decline and brain volume loss.
  • Avoid smoking and alcohol consumption.
  • Try to avoid stress by practising meditation or yoga.
  • Include fruits and vegetables in your diet as they contain antioxidants.
  • Eat nutritious food as it helps in cognitive stimulation.
  • Limit foods with high cholesterol and saturated fats.
  • Cut down on sugar, salt and processed foods.
  • Drink plenty of water.
  • Follow a healthy lifestyle as it helps in improving overall health and possibly protects the brain.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Author Details

Doctor image

Written By

Divya L

PharmaD

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:47 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Tolaz LA 405mg/vial Convenience Kit contains Olanzapine, an antipsychotic that balances the chemical messengers in the brain, improving mood, behaviour and thoughts.

Tolaz LA 405mg/vial Convenience Kit should be used with caution in the medical history of allergic reactions, liver or kidney diseases, heart problems, Alzheimer's disease, high cholesterol, glaucoma, diabetes, stomach/intestinal problems, breathing problem during sleep (sleep apnea), low white blood cell count, breast cancer, enlarged prostate, or fits. Please let your doctor know if you have any other medical history before starting the treatment with Tolaz LA 405mg/vial Convenience Kit.

Tolaz LA 405mg/vial Convenience Kit may make you sweat less and can likely cause a heart stroke. Hence, limiting activities that cause overheating, like an exercise in hot weather or using hot tubs, is advised. Drink plenty of fluids and dress lightly.

Tolaz LA 405mg/vial Convenience Kit may cause dizziness. It is advised to avoid getting up too fast from a sitting or lying position that can make you feel dizzy.

Olanzapine can cause side effects like orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. This medicine should be cautiously advised in people with cardiovascular and cerebrovascular diseases. Patients taking Tolaz LA 405mg/vial Convenience Kit are advised to regularly monitor their blood pressure levels to avoid any unpleasant events. It is also advised to be aware of a condition called tardive dyskinesia (uncontrolled movements of the face, lips, mouth, tongue, arms or legs) that may rarely occur while using this medicine.

Drug-Drug Interactions Checker List

  • CODEINE
  • HYDROCODONE
  • ALPRAZOLAM
  • DIAZEPAM
  • CARISOPRODOL
  • CYCLOBENZAPRINE
  • CETIRIZINE
  • DIPHENHYDRAMINE
  • CIMETIDINE
  • CARBAMAZEPINE
  • FLUVOXAMINE
  • FLUOXETINE
  • WARFARIN

Special Advise

  • Let your doctor know that you are taking Tolaz LA 405mg/vial Convenience Kit if you are undergoing any medical tests.
  • Weight gain has been noticed in patients who use Olanzapine; hence, regular weight monitoring is recommended.
  • Orthostatic hypotension is also recorded in patients using this medicine. Hence caution is recommended in patients with cardiovascular and cerebrovascular diseases. 
  • Tolaz LA 405mg/vial Convenience Kit may affect blood glucose levels; hence it is advised to monitor blood sugar levels regularly while using Tolaz LA 405mg/vial Convenience Kit. 
  • Timely monitoring of the cholesterol/triglyceride levels and Prolactin hormone levels is advised for the patient while using this medicine.

Disease/Condition Glossary

Schizophrenia: It is a condition in which the person may see, hear or feel things that are not there, believe things that are not true, or feel unusually suspicious or confused. Symptoms include hallucinations, delusions, thought disorders, movement disorders, disorganised thinking, loss of interest, lack of emotions, etc. Schizophrenia is triggered by physical, genetic, psychological, and environmental factors. Patients suffering from this disease may require lifelong treatment. Treatment involves a combination of medications, psychotherapy and care services.

Bipolar I disorder: It is a serious brain disorder in which a person goes through unusual mood changes (mood swings) and frequent changes in his/her behaviour and thinking. The symptoms may last at least seven days (most of the day, nearly every day), or the manic symptoms are so severe that the person needs immediate hospital care. Treatment involves mood stabilizers, antipsychotics, and sometimes sedative-hypnotics.

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