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Reviewed By Sunny S , MBBS
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Synonym

ATORVASTATIN+VITAMIN D3

Manufacturer/Marketer

Lupin Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Tonact D 20 Tablet 10's

Tonact D 20 Tablet 10's is a cholesterol-lowering medicine containing atorvastatin (statins or lipid reducer) and cholecalciferol (Vitamin D3). It helps lower bad cholesterol (low-density lipoprotein-LDL) and triglycerides (fats) levels. Hence, it reduces the risk of heart attack and stroke in the future. Two types of cholesterol are found in our body: good cholesterol (high-density lipoprotein) and bad cholesterol (low-density lipoprotein). Good cholesterol is good for our heart and helps reduce the bad cholesterol in our body. On the other hand, excess bad cholesterol (LDL) leads to the risk of heart diseases like heart attack and stroke.

Tonact D 20 Tablet 10's works by blocking liver enzymes, causing the liver to make less cholesterol. So, Tonact D 20 Tablet 10's increases the uptake and breakdown by the liver of cholesterol already in the blood. Thus, Tonact D 20 Tablet 10's lowers the levels of lipids known as cholesterol and triglycerides in the blood when lifestyle changes (like a low-fat diet) on their own have failed. Tonact D 20 Tablet 10's reduces the ‘bad’ cholesterol and increases the ‘good’ cholesterol by blocking our body’s production of ‘bad’ cholesterol. It also improves your body’s ability to remove it from your blood. Cholecalciferol is added to relieve the muscle pain caused due to atorvastatin. Collectively, Tonact D 20 Tablet 10's helps reduce cholesterol levels in the blood.

The prescribed dose of Tonact D 20 Tablet 10's is daily once a day at the same time. Your doctor will advise you on how often you take your tablets based on your medical condition. You can take Tonact D 20 Tablet 10's with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. In a few cases, you may experience allergic reactions, headache, blurred vision, pain, constipation, nausea, diarrhoea, muscle spasms, joint swelling, and back pain. Most of these side effects of Tonact D 20 Tablet 10's do not require medical attention and gradually resolve over time.

Tonact D 20 Tablet 10's may cause a breakdown of skeletal muscle tissue, leading to kidney failure. This condition usually occurs in the elderly, people with kidney disease, and poorly controlled hypothyroidism (underactive thyroid). Tonact D 20 Tablet 10's should not be prescribed to children less than ten years of age. You should contact a doctor before if you have had an allergic reaction to Tonact D 20 Tablet 10's, have liver or kidney problems, pregnant or planning to get pregnant, are breastfeeding, have severe lung disease, have a previous heart attack or stroke caused by bleeding in the brain, have hypothyroidism, drink more than two servings of alcohol per day and have a muscle disorder (fibromyalgia). The efficiency of Tonact D 20 Tablet 10's can be increased by taking low-fat or cholesterol-containing food and drinks.

Uses of Tonact D 20 Tablet 10's

High cholesterol, Prevention of heart attack and stroke.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Tonact D 20 Tablet 10's contains Atorvastatin (fat or lipid reducer) and Cholecalciferol (Vitamin D3). Atorvastatin works by blocking liver enzymes, causing the liver to make less cholesterol. So, Tonact D 20 Tablet 10's increases the uptake and breakdown by the liver of cholesterol already in the blood. Thus, Tonact D 20 Tablet 10's lowers the levels of lipids known as cholesterol and triglycerides in the blood when lifestyle changes (like a low-fat diet) on their own have failed. Tonact D 20 Tablet 10's reduces the ‘bad’ cholesterol and increases the ‘good’ cholesterol by blocking our body’s production of ‘bad’ cholesterol. It also improves your body’s ability to remove it from your blood. Cholecalciferol or Vitamin D3 is added to get relief from the musculoskeletal pain caused due to atorvastatin. Collectively, Tonact D 20 Tablet 10's helps reduce the raised cholesterol level in the bloodstream.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tonact D 20 Tablet 10's

  • Headache
  • Blurred vision
  • Muscle weakness
  • Allergic reactions
  • Constipation
  • Nausea
  • Diarrhoea
  • Back pain

Drug Warnings

Tonact D 20 Tablet 10's may cause serious muscle problems (myopathy and rhabdomyolysis) and can lead to kidney failure. This condition usually occurs in the elderly, people with kidney disease, and poorly controlled hypothyroidism (underactive thyroid). Tonact D 20 Tablet 10's should not be prescribed to children less than ten years of age. You should contact a doctor before if you have had an allergic reaction to Tonact D 20 Tablet 10's, have a liver problem (jaundice, liver cirrhosis), or kidney problems, are pregnant or planning to get pregnancy, are breastfeeding, have severe lung disease, have a previous heart attack or stroke caused by bleeding in the brain, have hypothyroidism, drink more than two servings of alcohol per day and have a muscle disorder (fibromyalgia) and damaged muscle tissue (rhabdomyolysis). Also, calcium levels can decrease in blood, so intake calcium supplements to avoid unpleasant side effects.

Drug-Drug Interactions

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AtorvastatinPosaconazole
Critical
AtorvastatinDarunavir
Severe

Drug-Drug Interactions

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AtorvastatinPosaconazole
Critical
How does the drug interact with Tonact D 20 Tablet:
Taking Tonact D 20 Tablet with Posaconazole can increase the blood levels of Tonact D 20 Tablet. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole with Tonact D 20 Tablet, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AtorvastatinDarunavir
Severe
How does the drug interact with Tonact D 20 Tablet:
Combining Tonact D 20 Tablet with darunavir may profoundly enhance Tonact D 20 Tablet levels in the blood. This can raise the chance of side effects (liver injury and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Tonact D 20 Tablet with darunavir can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinNicotinic acid
Severe
How does the drug interact with Tonact D 20 Tablet:
Combining Tonact D 20 Tablet with nicotinic acid may raise the risk of rhabdomyolysis, (an uncommon illness that leads to the destruction of skeletal muscle tissue). If you are elderly or have preexisting kidney disease, you may be at higher risk. This interaction is only relevant if you are taking large doses of nicotinic acid to treat high cholesterol. It does not apply if you are taking nicotinic acid in nutritional supplement amounts.

How to manage the interaction:
Taking Tonact D 20 Tablet and nicotinic acid together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you happen to experience, unexplained muscle pain, tenderness, weakness, fever, dark coloured urine, light coloured stools, you are advised to seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
AtorvastatinGemfibrozil
Severe
How does the drug interact with Tonact D 20 Tablet:
When Gemfibrozil is taken with Tonact D 20 Tablet, the chance of side effects such as liver damage and rhabdomyolysis, (an uncommon illness involving the breakdown of skeletal muscle tissue) increases.

How to manage the interaction:
Co-administration of Tonact D 20 Tablet along with Gemfibrozil together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinClofibrate
Severe
How does the drug interact with Tonact D 20 Tablet:
Using clofibrate together with Tonact D 20 Tablet can increase the risk of side effects.

How to manage the interaction:
Co-administration of Clofibrate with Tonact D 20 Tablet can result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on your health and contact a doctor right away if you notice any of these signs - liver problems, muscle damage, kidney problems, complications, pain, weakness, fever, dark urine, chills, joint pain, swelling, bruising, rash, itching, loss of appetite, tiredness, feeling sick, throwing up, or bleeding. Do not stop using any medications without a doctor's advice.
AtorvastatinClarithromycin
Severe
How does the drug interact with Tonact D 20 Tablet:
Co-administration of Tonact D 20 Tablet with Clarithromycin possibly enhances Tonact D 20 Tablet levels in the blood. This can raise the chance of side effects (liver damage and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Tonact D 20 Tablet if prescribed by the doctor. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinErlotinib
Severe
How does the drug interact with Tonact D 20 Tablet:
Coadministration of Erlotinib with Tonact D 20 Tablet can raise the chance of side effects (liver injury and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Erlotinib with Tonact D 20 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AtorvastatinAtazanavir
Severe
How does the drug interact with Tonact D 20 Tablet:
Combining Tonact D 20 Tablet with atazanavir may drastically elevate Tonact D 20 Tablet levels in the blood. This can raise the chance of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Tonact D 20 Tablet with atazanavir can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinKetoconazole
Severe
How does the drug interact with Tonact D 20 Tablet:
Using Tonact D 20 Tablet with ketoconazole, may raise the chance of side effects (liver injury and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Tonact D 20 Tablet with ketoconazole can result in an interaction, it can be taken if a doctor has recommended it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not discontinue any medication without consulting a doctor.
AtorvastatinRifampicin
Severe
How does the drug interact with Tonact D 20 Tablet:
Taking Tonact D 20 Tablet with rifampicin can decrease the blood levels of Tonact D 20 Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Tonact D 20 Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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ATORVASTATIN-20MG+CHOLECALCIFEROL-1000IUFruit juices
Moderate

Drug-Food Interactions

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ATORVASTATIN-20MG+CHOLECALCIFEROL-1000IUFruit juices
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Blood levels of Tonact D 20 Tablet can rise after consuming grapefruit juice. Before quitting the drug, speak to a doctor even though there may be an interaction. Additionally, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, or yellowing of the skin or eyes, you should consult a doctor. Without first consulting your doctor, never stop taking the medication.

Diet & Lifestyle Advise

  • Try aromatherapy, yoga, and meditation to help relax your body and mind.
  • Try to do breathing exercises to get more oxygen.
  • Eat a healthy diet rich in soluble fibre like beans, legumes, whole grain, flax, apples, and citrus fruits.
  • Try to replace most of your saturated fats with unsaturated fats that can reduce total cholesterol and LDL cholesterol quickly. Foods like avocados, olive oil, fatty fish, and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.
  • Try to adopt a Mediterranean-style diet rich in olive oil, fruits, vegetables, nuts, whole grains, and fish, low in red meat and most dairy.
  • Try to give priority to more fruits and veggies in your daily meal as these contain antioxidants which help to lower LDL
  • Minimize the intake of added sugar. The American Heart Association (ADA) recommends that one should not eat more than 100 calories (25 grams) of added sugar for women and children and no more than 150 calories (37.5 grams) for men every day.
  • American Heart Association recommends that sodium chloride (table salt) intake should not exceed more than 2,300 mg per day as part of a healthy eating pattern.
  • As a precautionary measure, do not consume alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIANGINALS

Tonact D 20 Tablet 10's Substitute

Substitutes safety advice
  • Lipicure-D 20 Tablet 10's

    by Others

    27.18per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • TETRACYCLINE
  • VERAPAMIL
  • DILTIAZEM
  • CIMETIDINE
  • FLUCONAZOLE
  • KETOCONAZOLE
  • ABACAVIR
  • RETROVIR
  • RIBAVIRIN
  • DIGOXIN
  • AMIODARONE

Disease/Condition Glossary

Hyperlipidemia: High cholesterol, known as hyperlipidemia or dyslipidemia, occurs when there is an excess of the unhealthy cholesterol balance in the blood. When there is a high cholesterol level in the blood, your arteries get narrowed and clogged, which finally contributes to heart diseases like stroke and heart attack. Eating high-fat or high-cholesterol-containing food/drinks and genetic factors are the primary causes of high cholesterol.

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