TOPIRATE 25MG TABLET belongs to a group of medicines called “antiepileptic (AED)/ anticonvulsant agent' that is primarily indicated in the treatment of epilepsy (Monotherapy and Adjunctive therapy) and It can also be taken to prevent migraine. Epilepsy is a chronic disorder that is responsible for causing unprovoked, recurrent seizures in the body. A seizure is a sudden attack in the brain that makes a person lose control of their actions. Migraine is a mental condition that often causes intense or debilitating headaches with difficulty speaking, nausea, vomiting, and sensitivity to light or sound.

TOPIRATE 25MG TABLET is responsible for restoring the balance of neural activity by diminishing the spread of seizure movement in the brain. By controlling the electrical activity of the brain, it controls seizures and relieves the symptoms of migraine. Take TOPIRATE 25MG TABLET in an empty stomach without food with one glass of water. TOPIRATE 25MG TABLET is only available on prescription. It comes as tablets or capsules intended to be taken by mouth only. Swallow the medication as a whole without crushing or breaking it. TOPIRATE 25MG TABLET doses are sometimes advised according to the weight of children so the doctor will change the dose if the child gains or lose weight.

The possible side effects of topiramate include feeling sleepy, dizziness, diarrhoea and feeling sick. Some of the side effects do not even require medical attention and these are usually mild and go away by themselves. Consult with the doctor if any of these side effects continue or get worse with time.

The use of $mame is restricted in persons who are hypersensitive to it, so tell your doctor if you have any allergy to any of the chemical constituents present in this medicine. Tell your doctor if you ever had or already dealing with diarrhoea, glaucoma, metabolic acidosis, lung disease, breathing problems, liver disease, a blood disorder called acute porphyria etc. If a woman is pregnant or planning to pregnant then they should tell their doctor as the use of this medicine during pregnancy may increase the risk of cleft lip and/or cleft palate which is a birth defect in the newborn that may develop during early pregnancy.

TOPIRATE 25MG TABLET is an antiepileptic (AED) medicine that is used to treat epilepsy in mono or adjunctive therapy and migraine. In Monotherapy epilepsy, TOPIRATE 25MG TABLET is suggested for patients above 2 years of age with partial-onset or primary generalized tonic-clonic seizures. In Adjunctive therapy epilepsy, TOPIRATE 25MG TABLET is suggested in patients of 2 to 16 years of age with partial-onset seizures or primary generalized tonic-clonic seizures while in patients more than 2 years of age, TOPIRATE 25MG TABLET is suggested in patients with seizures associated with Lennox-Gastaut syndrome (LGS). In migraine, TOPIRATE 25MG TABLET is suggested for prophylaxis of migraine. TOPIRATE 25MG TABLET works by blocking the voltage-dependent sodium and calcium channels and increasing the inhibitory actions of GABA. In epilepsy, TOPIRATE 25MG TABLET controls the uncontrolled activity of nerves in the brain and thus prevents or controls seizures. While in migraine, TOPIRATE 25MG TABLET tranquilizes the overactive nerve cells in the brain that are responsible for causing migraine.

• Tingling of the arms and legs
• Not feeling hungry
• Nausea
• Change in taste
• Diarrhoea
• Weight loss
• Nervousness
• Upper respiratory tract infection

TOPIRATE 25MG TABLET may cause a congenital disability called cleft lip in unborn baby, so the use of this medicine is not allowed in pregnant females. TOPIRATE 25MG TABLET may increase the body temperature and reduce sweating, so one should report it to the doctor if they are noticing decreased sweating and hot, dry skin. TOPIRATE 25MG TABLET may enhance the level of acid in the blood so one should tell their doctor if they have irregular heartbeats or loss of hunger. Before taking TOPIRATE 25MG TABLET, tell the doctor if you have diarrhoea, metabolic acidosis, eye problems, liver disease. TOPIRATE 25MG TABLET may affect the working of contraceptives that include the combined pill, vaginal ring, patches,progestogen-only contraceptive pill, and emergency contraception. So, one should tell their doctor if they are using any contraceptives to prevent pregnancy.

Drug-Drug Interaction: A person should tell the doctor about all the medications they are using, including the medicines used to treat diabetes (metformin, glibenclamide, pioglitazone), medicines used to treat depression or anxiety  (venlafaxine, amitriptyline), medicines for heart or blood pressure (diltiazem, hydrochlorothiazide, propranolol), antipsychotic medicines (risperidone), and or any other epilepsy medicines.

Drug-Food Interaction: The use of alcohol with TOPIRATE 25MG TABLET is restricted as alcohol may worsen the side effects of the medicine.

Drug-Disease Interaction: The use of TOPIRATE 25MG TABLET is restricted in patients dealing with bone marrow depression/blood dyscrasias, hyperthermia, severe liver disease, suicidal tendency, renal dysfunction, metabolic acidosis, angle-closure glaucoma, hemodialysis, and nephrolithiasis.

• METFORMIN
• GLIBENCLAMIDE
• PIOGLITAZONE
• VENLAFAXINE
• AMITRIPTYLINE
• DILTIAZEM
• HYDROCHLOROTHIAZIDE
• PROPRANOLOL
• RISPERIDONE

• Eat a balanced diet that consists of good fats, proteins, carbohydrates, vegetables, and fruit which helps the body and brain to work properly and keep a person healthy and energetic.
• Fatigue is one of the primary reasons that trigger seizures in the body, so sleeping properly can help in relaxing the brain.
• One should avoid the consumption of alcohol as it can trigger seizures in patients. Even one or two glasses can trigger epilepsy and worsen the side effects of TOPIRATE 25MG TABLET.
• Keep yourself happy and avoid taking emotional stress as stress causes seizures. Persons who maintain healthy stress levels have reported that they have responded well to the medicine.

Epilepsy: It is a neurological disorder in which brain activity becomes abnormal characterized by intense electrical bursts in the brain (seizures). When these bursts happen in one part of the brain it is called a partial seizure while if these bursts occur in the complete brain it is called a generalized seizure. Sometimes, a person starts experiencing the symptoms before starting of seizure that includes a sudden feeling of fear, dizziness, changes in vision, shakiness in arms and legs, and headache. While the symptoms that occur during a seizure include losing consciousness, characterized by confusion, uncontrollable muscle spasms, falling, biting tongue, sudden, rapid eye movements, unusual noises, such as grunting, sudden mood changes, etc.

Migraine: It is a mild to severe headache that starts as a dull ache in the region around the eye. It usually lasts a few hours up to several days and gets worst with the movement. The possible warning signs that can start before the occurrence of migraine include visual changes, unusual tiredness, tingling in an arm or leg. A person facing migraine may also face mild to severe pain in the head, pulsing, throbbing pain in the head, sensitivity to sound and light, vomiting, and Nausea.