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  3. Topotec 2.5Mg Inj

Topotec 2.5Mg Inj, Pack of 1 Tablet
Topotec 2.5Mg Inj, Pack of 1 Tablet
Topotec 2.5Mg Inj, Pack of 1 Tablet
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Composition :

TOPOTECAN-2.5MG

Manufacturer/Marketer :

Unitech Health Care Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Topotec 2.5Mg Inj

Topotec 2.5Mg Inj belongs to a group of medicines called 'anti-cancer/anti-neoplastic agents', used to treat ovarian and small cell lung cancer. On the other hand, it may use to treat advanced cervical cancer if surgery or radiotherapy treatment is not possible. It may sometimes be used to treat other cancers. Ovarian cancer begins in the ovaries (a pair of female reproductive glands in which the ova, or eggs, are formed). Small-cell lung cancer is a disease in which malignant (cancer) cells form in the lung tissues.

Topotec 2.5Mg Inj contains 'Topotecan'. It works by penetrating into the cell wall and binding to the cell's DNA, stopping it from naturally dividing and functioning, ultimately destroying it. These medicines target cancer cells because they often affect rapidly dividing cells.

The amount of medicine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule. Topotec 2.5Mg Inj is prescribed by a doctor experienced in the use of medications to treat cancer. You may sometimes experience nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy (nerves malfunction), nephrotoxicity at high doses, and electrolyte disturbances. Most of these side effects of Topotec 2.5Mg Inj do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Topotec 2.5Mg Inj for as long as your doctor has prescribed. Do not stop using the Topotec 2.5Mg Inj midway. Talk to your doctor before taking Topotec 2.5Mg Inj if you have severe allergic reactions to Topotec 2.5Mg Inj or other medicines or suffer from severe lung problems, Infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Topotec 2.5Mg Inj if you are pregnant or breastfeeding because this Topotec 2.5Mg Inj can cause harmful effects on the unborn baby. Both women and men using this Topotec 2.5Mg Inj should use birth control to avoid pregnancy.

Uses of Topotec 2.5Mg Inj

Ovarian cancer and Small cell lung cancer

Directions for Use

Topotec 2.5Mg Inj will be administered by a qualified healthcare professional. Hence, do not self-administer.

Medicinal Benefits

Topotec 2.5Mg Inj contains 'Topotecan', which belongs to a group of anti-cancer medicines used to treat ovarian cancer and small cell lung cancer. It works by damaging the genetic material (DNA) of the cancer cells, which stops their growth and multiplication. It can be used alone or together with other chemotherapy drugs depending on the type of cancer you have.

Storage

Keep Topotec 2.5Mg Inj out of the sight and reach of children.
Side effects of Topotec 2.5Mg Inj
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug Warnings

Topotec 2.5Mg Inj will be administered by a healthcare professional. To treat your condition effectually, continue taking Topotec 2.5Mg Inj for as long as your doctor has prescribed. Do not stop Topotec 2.5Mg Inj midway. Talk to your doctor before taking Topotec 2.5Mg Inj if you have severe allergic reactions to Topotec 2.5Mg Inj or other medicines or suffer from severe lung problems, Infections, renal dysfunction, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), hepatic disorders. Topotec 2.5Mg Inj should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Topotec 2.5Mg Inj if you are pregnant or breastfeeding because this Topotec 2.5Mg Inj can cause harmful effects on the unborn baby. Both women and men using this Topotec 2.5Mg Inj should use birth control to avoid pregnancy. Peripheral blood counts should be frequently monitored during Topotec 2.5Mg Inj treatment and appropriate until recovery is achieved. Do not receive any kind of immunization or vaccination without your doctor's approval while taking the Topotec 2.5Mg Inj.

Drug-Drug Interactions

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TopotecanInfliximab
Severe
TopotecanCarboplatin
Severe

Drug-Drug Interactions

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TopotecanInfliximab
Severe
How does the drug interact with Topotec 2.5Mg Inj:
Combining Infliximab with Topotec 2.5Mg Inj can increase the risk and severity of side effects.

How to manage the interaction:
Co-administration of Topotec 2.5Mg Inj with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TopotecanCarboplatin
Severe
How does the drug interact with Topotec 2.5Mg Inj:
When carboplatin is used with Topotec 2.5Mg Inj, it may increase the risk of side effects.

How to manage the interaction:
Co-administration of carboplatin with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting your doctor.
TopotecanClozapine
Severe
How does the drug interact with Topotec 2.5Mg Inj:
When Clozapine is taken with Topotec 2.5Mg Inj, the effect of Clozapine in the blood can go up.

How to manage the interaction:
Although there is a possible interaction between Topotec 2.5Mg Inj and Clozapine, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, weight loss, pain or burning during urination - it's important to contact your doctor right away. They may be able to recommend other options that won't cause any problems with your current medications. Do not stop using any medications without a doctor's advice.
TopotecanTofacitinib
Severe
How does the drug interact with Topotec 2.5Mg Inj:
Taking Tofacitinib with Topotec 2.5Mg Inj may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and Topotec 2.5Mg Inj, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TopotecanThalidomide
Severe
How does the drug interact with Topotec 2.5Mg Inj:
Taking thalidomide together with Topotec 2.5Mg Inj may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Topotec 2.5Mg Inj together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
TopotecanBaricitinib
Severe
How does the drug interact with Topotec 2.5Mg Inj:
Coadministration of baricitinib and Topotec 2.5Mg Inj can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Topotec 2.5Mg Inj if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
TopotecanEtanercept
Severe
How does the drug interact with Topotec 2.5Mg Inj:
When Etanercept is used with Topotec 2.5Mg Inj, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Topotec 2.5Mg Inj and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Topotec 2.5Mg Inj Substitute

Substitutes safety advice

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:46 AM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Topotec 2.5Mg Inj contains 'Topotecan'. Topotecan works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.

If you are allergic to topotecan or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Topotec 2.5Mg Inj.

Yes, Topotec 2.5Mg Inj can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.

Avoid taking Topotec 2.5Mg Inj if you are pregnant because Topotec 2.5Mg Inj can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Topotec 2.5Mg Inj.

The live vaccine may not work while on treatment with Topotec 2.5Mg Inj. Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Topotec 2.5Mg Inj is used to treat ovarian or small cell lung cancer that has come back after chemotherapy. On the other hand, it can also treat advanced cervical cancer if surgery or radiotherapy treatment is not possible. When treating cervical cancer, Topotec 2.5Mg Inj is used with another medication called cisplatin.

Drug-Drug Interactions Checker List

  • PACLITAXEL
  • BEVACIZUMAB

Special Advise

  • Topotec 2.5Mg Inj should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Topotec 2.5Mg Inj.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
  • Peripheral blood counts should be frequently monitored during Topotec 2.5Mg Inj treatment and, when appropriate until recovery is achieved.
  • Avoid unnecessary or prolonged exposure to sunlight and UV light (such as tanning booths) and wear protective clothing, sunglasses, and sunscreen. Topotec 2.5Mg Inj may make your skin sensitive to sunlight.

Disease/Condition Glossary

Cancer: Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs. Cancer sometimes begins in one body part before spreading to other areas.

Ovarian cancer: Ovarian cancer is a type of cancer that begins in the ovaries (one of a pair of female reproductive glands in which the ova, or eggs, are formed).

Small cell lung cancer: Small cell lung cancer is a disease in which malignant (cancer) cells form in the lung tissues.

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