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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About TORISEL 25MG INJECTION

TORISEL 25MG INJECTION belongs to the group of anti-cancer medicines called kinase inhibitors used to treat advanced renal cell carcinoma (a type of cancer that begins in the kidney). It may also be used for previously treated mantle cell lymphoma (a type of cancer affecting the lymph nodes).
 
TORISEL 25MG INJECTION contains Temsirolimus, which works by blocking the action of abnormal proteins needed for cancer cells to multiply. This helps slow the growth of tumours. Thereby, it helps treat kidney cancer.
 
In some cases, TORISEL 25MG INJECTION may cause side effects such as diarrhoea, nausea, vomiting, constipation, headache, fever, and decreased appetite. Most of these side effects may not require medical attention and resolve over time. Do not be reluctant to talk with your doctor if any of these side effects persist or worsen.
 
Consult the doctor if you are pregnant or breastfeeding. TORISEL 25MG INJECTION is not recommended for children below 18 years as the effectiveness has not been established. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

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Whats That

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Non returnable*
COD available

Online payment accepted

Manufacturer/Marketer

Pfizer Ltd

Consume Type

PARENTERAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of TORISEL 25MG INJECTION

 Renal cell cancer (Kidney cancer).

Medicinal Benefits

TORISEL 25MG INJECTION belongs to the group of anti-cancer medicines called kinase inhibitors used to treat advanced renal cell carcinoma (a type of cancer that begins in the kidney). It may also be used for previously treated mantle cell lymphoma (a type of cancer affecting the lymph nodes). TORISEL 25MG INJECTION contains Temsirolimus, a selective inhibitor of the enzyme mTOR (mammalian target of rapamycin) that blocks tumour cell growth and division. Thereby, it helps treat kidney cancer.

Side Effects of TORISEL 25MG INJECTION

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Fever
  • Loss of appetite
  • Sores or inflammation in the mouth
  • Cough

Directions for Use

TORISEL 25MG INJECTION will be administered by a healthcare professional who is trained and experienced in the administration of anticancer medicine; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not use TORISEL 25MG INJECTION if you are allergic to any of its components if you are allergic to sirolimus (immunosuppressant), or if you have mantle cell lymphoma or liver problems. Inform the doctor if you are allergic to or cannot use anti-histamines if you have/had a tumour in the brain or spinal cord, bruising/bleeding problems, infections, inflammation of lungs, liver or kidney problems, high cholesterol levels, diabetes, eye problems, if you are taking anticoagulants if you drink alcohol or are alcoholic if you are due to undergo any vaccination or surgery, or if you are over 65 years of age. Consult the doctor if you are pregnant or breastfeeding. TORISEL 25MG INJECTION is not recommended for children below 18 years as the effectiveness has not been established.

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

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TemsirolimusCladribine
Severe
TemsirolimusEzetimibe
Severe

Drug-Drug Interactions

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TemsirolimusCladribine
Severe
How does the drug interact with TORISEL 25MG INJECTION:
Combining Cladribine with TORISEL 25MG INJECTION can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladribine and TORISEL 25MG INJECTION together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
TemsirolimusEzetimibe
Severe
How does the drug interact with TORISEL 25MG INJECTION:
Taking TORISEL 25MG INJECTION and Ezetimibe can increase blood levels of cholesterol and triglycerides.

How to manage the interaction:
There may be a possibility of interaction between Ezetimibe and TORISEL 25MG INJECTION, but it can be taken if prescribed by a doctor. If you are taking sirolimus or TORISEL 25MG INJECTION along with your cholesterol-lowering medications, it is important to regularly check blood cholesterol and triglyceride levels with a doctor. Do not discontinue any medications without consulting a doctor.
TemsirolimusEtodolac
Severe
How does the drug interact with TORISEL 25MG INJECTION:
Taking Etodolac and TORISEL 25MG INJECTION can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Etodolac and TORISEL 25MG INJECTION, you can take these medicines together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
TemsirolimusPiroxicam
Severe
How does the drug interact with TORISEL 25MG INJECTION:
Taking Piroxicam with TORISEL 25MG INJECTION may increase the risk of kidney damage.

How to manage the interaction:
Taking Piroxicam with TORISEL 25MG INJECTION together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without consulting a doctor.
TemsirolimusAmphotericin b
Severe
How does the drug interact with TORISEL 25MG INJECTION:
Coadministration of Amphotericin b and TORISEL 25MG INJECTION may increase the risk of kidney problem.

How to manage the interaction:
Although taking Amphotericin b and TORISEL 25MG INJECTION together can cause an interaction, it can be taken if a doctor has suggested it. If you experience any changes like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not discontinue any medications without consulting the doctor.
TemsirolimusFosphenytoin
Severe
How does the drug interact with TORISEL 25MG INJECTION:
When TORISEL 25MG INJECTION is taken with Fosphenytoin, it can cause TORISEL 25MG INJECTION to be broken down faster in the body. This can lead to low treatment outcomes

How to manage the interaction:
Although taking Fosphenytoin and TORISEL 25MG INJECTION together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any unusual symptoms or if your condition worsens, make sure to contact your doctor right away. Do not stop using any medications without talking to your doctor.
TemsirolimusTofacitinib
Severe
How does the drug interact with TORISEL 25MG INJECTION:
Taking Tofacitinib with TORISEL 25MG INJECTION may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and TORISEL 25MG INJECTION, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TemsirolimusVoriconazole
Severe
How does the drug interact with TORISEL 25MG INJECTION:
Using TORISEL 25MG INJECTION together with Voriconazole may significantly increase the blood levels and effects of TORISEL 25MG INJECTION.

How to manage the interaction:
Although taking Voriconazole and TORISEL 25MG INJECTION together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
TemsirolimusApixaban
Severe
How does the drug interact with TORISEL 25MG INJECTION:
Coadministration of TORISEL 25MG INJECTION and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining TORISEL 25MG INJECTION and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
TemsirolimusFondaparinux
Severe
How does the drug interact with TORISEL 25MG INJECTION:
Taking fondaparinux with TORISEL 25MG INJECTION can increase the risk of bleeding.

How to manage the interaction:
Taking Fondaparinux with TORISEL 25MG INJECTION together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables, whole grains and fruits in your diet.
  • Avoid fast, fried foods, processed meats, highly processed foods and beverages, and salty snacks.
  • Get optimal sleep; rest well.

Habit Forming

No

Special Advise

Females of reproductive potential and males with partners of reproductive potential must use effective contraception during treatment and for three months after the last dose.

Disease/Condition Glossary

Renal cell carcinoma: Renal cell carcinoma, also known as kidney cancer or renal cell adenocarcinoma, is a type of cancer in which cancer cells are found in the lining of tubules in the kidney. Smoking and certain pain medicines may affect the risk of renal cell cancer. Symptoms include blood in the urine, a lump in the abdomen, pain in the side that does not go away, anaemia, loss of appetite, and weight loss for no known reason.

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