Trajenta Duo 2.5 mg/1000 mg Tablet 10's is a combination drug of Linagliptin (DPP4 inhibitors) and Metformin (Biguanides) belongs to the anti-diabetic class. Type 2 diabetes is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or resistance to insulin action. As a result, insulin is produced in large amounts but cannot act on the body's organs.

Trajenta Duo 2.5 mg/1000 mg Tablet 10's contains Linagliptin (DPP4 inhibitors) and Metformin (Biguanide). Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that blocks the action of DPP-4, an enzyme that destroys the hormone incretin that helps the body produce more insulin only when required. It also reduces the amount of sugar produced by the liver when not needed. Metformin functions by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's sensitivity to insulin. Together, it prevents blood glucose levels from rising to very high levels after meals.

Trajenta Duo 2.5 mg/1000 mg Tablet 10's should be taken with food to avoid an upset stomach. Trajenta Duo 2.5 mg/1000 mg Tablet 10's should be taken at the same time of the day each time for the best results. Your doctor will decide what dose should be taken for better advice, which can change quickly depending on your condition. The most common side effect of Trajenta Duo 2.5 mg/1000 mg Tablet 10's is hypoglycemia (low blood glucose levels) characterized by dizziness, sweating, palpitations, hunger pangs, dry mouth, skin, etc. So to avoid hypoglycemia, you should not miss meals and should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

Trajenta Duo 2.5 mg/1000 mg Tablet 10's should not be stopped even if you feel better without consulting your doctor as the sugar level keeps changing. If you stop taking Trajenta Duo 2.5 mg/1000 mg Tablet 10's abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy). Trajenta Duo 2.5 mg/1000 mg Tablet 10's should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have heart disease or are planning to get pregnant or breastfeed.

Trajenta Duo 2.5 mg/1000 mg Tablet 10's helps your pancreas produce more insulin, make effective insulin utilization, and decrease the excess sugar that your liver makes. It helps control the rise of blood sugar levels in your body after a meal. Besides this, it does not cause weight gain in prolonged use. Trajenta Duo 2.5 mg/1000 mg Tablet 10's plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer, and delayed wound healing.

• Low blood sugar
• Runny nose
• Sore throat
• Upper lung infection
• Diarrhoea
• Nausea
• Vomiting
• Gas
• Stomach upset
• Indigestion,
• General weakness
• Headache

Trajenta Duo 2.5 mg/1000 mg Tablet 10's should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking Trajenta Duo 2.5 mg/1000 mg Tablet 10's, might develop a rare but serious condition called lactic acidosis. In this condition, there is too much lactic acid accumulated in the blood that can damage the working of your liver and kidney required for the elimination of excess lactic acid from the blood. Before you start taking Trajenta Duo 2.5 mg/1000 mg Tablet 10's, tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 level. Trajenta Duo 2.5 mg/1000 mg Tablet 10's, when used with insulin, may extremely lower the blood sugar level leading to hypoglycemia condition, which can be fatal. Your doctor may adjust the dose by lowering the dose of insulin or Trajenta Duo 2.5 mg/1000 mg Tablet 10's in this case. A prolonged intake of Trajenta Duo 2.5 mg/1000 mg Tablet 10's may lower your thyroid-stimulating hormone (TSH); hence, TSH's annual check-up is recommended. You may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention in rare cases. Tell your doctor if you will have a diagnostic test with an injection of dye or X-ray contrast agent. The use of Trajenta Duo 2.5 mg/1000 mg Tablet 10's should be stopped for a short time before having an X-ray procedure.

Drug-Drug Interactions: Trajenta Duo 2.5 mg/1000 mg Tablet 10's interacts with anti-depressants (bupropion), pain killers (aspirin), antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (ranolazine, digoxin), anti-HIV drugs (dolutegravir), anti-hypertensives (amlodipine, verapamil), anti-epileptic drugs (topiramate, lamotrigine), oral contraceptives.

Drug-Food Interactions: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Trajenta Duo 2.5 mg/1000 mg Tablet 10's.

Drug-Disease Interactions: People affected with heart diseases (like congestive heart failure and myocardial infarction), Vitamin B12 deficiency, and alcoholism should avoid intake of Trajenta Duo 2.5 mg/1000 mg Tablet 10's.

• ASPIRIN
• CIPROFLOXACIN
• CIMETIDINE
• DIGOXIN
• AMLODIPINE
• TOPIRAMATE
• LAMOTRIGINE
• BUPROPION
• CEPHALEXIN
• RANOLAZINE
• DOLUTEGRAVIR
• VERAPAMIL

• Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.
• Eat at regular intervals. Do not take a long gap between a meal or snack.
• Monitor your blood sugar level regularly, especially when there are lots of fluctuations.
• Invest at least 150 minutes of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise weekly.
• Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
• Replace refined carbohydrates containing whole-grain foods and increase the intake of fruits, veggies, and other fibre-enriched foods.
• Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
• Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
• Keep your blood pressure as normal (140/90) as possible as it reduces the risk of cardiovascular diseases in diabetes patients.

Type 2 diabetes is a condition where the body cannot make sufficient insulin, or the insulin that it makes doesn't work properly or is utilized by our body. This can cause high blood sugar levels (hyperglycemia). Type 2 diabetes symptoms include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. There may be weight gain in some cases, while weight loss may be observed in rare cases. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), and retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increase the chance of heart attack or stroke.