TRAMADIN PLUS TABLET belongs to a class of drugs called analgesics (pain killers) primarily used to treat moderate to severe pain. Pain is an unpleasant sensation caused by an injury or illness. Pain may be acute (short term) or chronic (long term). It can be general (overall body pains) or localized (pain in a specific area of the body).

TRAMADIN PLUS TABLET is a combination of two drugs, namely: Tramadol (opioid analgesic) and Acetaminophen (analgesic and antipyretic). Tramadol works by mimicking the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby inhibits the transmission of pain signals from nerves to the brain. Also, it improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain. Acetaminophen is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins that are responsible for pain and fever.

Take TRAMADIN PLUS TABLET as prescribed by your doctor. You are advised to take TRAMADIN PLUS TABLET for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience drowsiness, nausea, dizziness, headache, vomiting, dry mouth, constipation, excessive sweating, shaking, confusion or mood changes. Most of these side effects of TRAMADIN PLUS TABLET do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

If you are allergic to TRAMADIN PLUS TABLET or any other medicines, please tell your doctor. TRAMADIN PLUS TABLET is not recommended for children below 12 years of age, as the safety and effectiveness were not established. Avoid taking TRAMADIN PLUS TABLET if you are pregnant as it may cause withdrawal symptoms in the newborn baby. TRAMADIN PLUS TABLET may be excreted in human milk. Please consult a doctor if you are breastfeeding. It is an offence to drive if TRAMADIN PLUS TABLET affects you. Therefore, avoid driving if you feel drowsy or dizzy after taking TRAMADIN PLUS TABLET. Avoid alcohol consumption with TRAMADIN PLUS TABLET as it may increase drowsiness.

TRAMADIN PLUS TABLET is a combination of two drugs: Tramadol and Acetaminophen to treat moderate to severe pain. Tramadol mimics the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby inhibits the transmission of pain signals from nerves to brain. Also, it improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain. Acetaminophen is an analgesic (relieves pain) and antipyretic (reduces fever) that inhibits the production of certain chemical messengers in the brain known as prostaglandins responsible for pain and fever.

• Drowsiness
• Nausea
• Dizziness
• Headache
• Vomiting
• Dry mouth
• Constipation
• Excessive sweating
• Shaking
• Confusion
• Mood changes

If you are allergic to TRAMADIN PLUS TABLET or any other medicines, please tell your doctor. TRAMADIN PLUS TABLET is not recommended for children below 12 years of age, as the safety and effectiveness were not established. Avoid taking TRAMADIN PLUS TABLET if you are pregnant as it may cause withdrawal symptoms in the newborn baby. TRAMADIN PLUS TABLET may be excreted in human milk. Please consult a doctor if you are breastfeeding. If you have fits, asthma, severe lung problems, drug dependence,  liver or kidney problems, inform your doctor before taking TRAMADIN PLUS TABLET. It is an offence to drive if TRAMADIN PLUS TABLET affects you. Therefore, avoid driving if you feel drowsy or dizzy after taking TRAMADIN PLUS TABLET. Avoid alcohol consumption with TRAMADIN PLUS TABLET as it may increase drowsiness. Do not take TRAMADIN PLUS TABLET if you are taking pain relievers, sleeping pills, or taking medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine and methylene blue injection in the past 14 days. Inform your doctor immediately if you experience any sleep-related breathing problems such as sleep apnoea (breathing stops and starts repeatedly) while taking TRAMADIN PLUS TABLET.

Drug-Drug Interactions: TRAMADIN PLUS TABLET may interact with anticonvulsants (carbamazepine, pregabalin), opioid pain killers (pentazocine, buprenorphine, nalbuphine, morphine), cough medication (codeine), muscle relaxant (baclofen), blood thinners (warfarin, phenprocoumon), antiemetic drugs (ondansetron, metoclopramide, domperidone), high cholesterol lowering medicine (cholestyramine), sedative-hypnotics (zolpidem), pain relievers (celecoxib), antidepressants (duloxetine, escitalopram), and anti-anxiety drugs (alprazolam).

Drug- Food Interactions: Avoid foods rich in carbohydrates, pectin including jellies, cabbage, Brussels sprouts and broccoli as TRAMADIN PLUS TABLET may interact with these foods. TRAMADIN PLUS TABLET may interact with grapefruit juice. Therefore, avoid intake of grapefruit juice with TRAMADIN PLUS TABLET as it may increase TRAMADIN PLUS TABLET levels in the body. Also, avoid alcohol consumption while taking TRAMADIN PLUS TABLET as it may increase drowsiness.

Drug-Disease Interactions: If you have fits, asthma, severe lung problems, severe headaches associated with vomiting, drug dependence,  liver or kidney problems or if you have recently suffered from shock or head injury, inform your doctor before taking TRAMADIN PLUS TABLET.

• CARBAMAZEPINE
• PREGABALIN
• PENTAZOCIN
• BUPRENORPHINE
• MORPHINE
• CODEINE
• BACLOFEN
• WARFARIN
• PHENPROCOUMON
• ONDANSETRON
• METOCLOPRAMIDE
• DOMPERIDONE
• CHOLESTYRAMINE
• ZOLPIDEM
• CELECOXIB
• DULOXETINE
• ESCITALOPRAM
• ALPRAZOLAM
• NALBUPHINE

• Do regular exercises such as swimming or walking.
• Drink plenty of water while taking TRAMADIN PLUS TABLET to avoid dry mouth.
• Maintain a fibre rich diet and eat plenty of fresh fruits and vegetables to avoid constipation while taking TRAMADIN PLUS TABLET.
• Avoid consumption of alcohol and quit smoking.

• Patients with severe liver or kidney insufficiency should avoid taking TRAMADIN PLUS TABLET.
• Do not give TRAMADIN PLUS TABLET to others. Use TRAMADIN PLUS TABLET only when prescribed by a doctor and avoid frequent or high doses as it may cause addiction.
• Please do not stop taking TRAMADIN PLUS TABLET suddenly as it may cause withdrawal symptoms such as difficulty in sleeping, anxiety, nervousness, shaking, stomach or bowel disorders or make you overactive. Therefore, take TRAMADIN PLUS TABLET for as long as your doctor has prescribed it.

Pain is an unpleasant sensation caused by an injury or illness. Pain may be acute (short term) or chronic (long term). It can be general (overall body pains) or localized (pain in a specific area of the body). Pain is highly subjective as some people have a high tolerance for pain while others have a low tolerance. Although pain is inconvenient and unpleasant, it hints about causes when something is wrong in the body. Pain may be caused due to cramps, headache, bone fractures, stomach pain, arthritis (swelling of one or more joints), muscle strain or overuse, cuts, flu, irritable bowel syndrome (an intestinal disorder causing stomach pain, diarrhoea or constipation) and fibromyalgia (muscle pain with stiffness and tenderness).