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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

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Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Trenaxa Injection 5 ml

Trenaxa Injection 5 ml belongs to the class of medications called ‘anti-fibrinolytic drugs. It is mainly used to treat abnormal bleeding in various conditions such as menorrhagia (heavy bleeding in periods), epistaxis (nose bleeds), cervical surgery (conization of the cervix), post-prostatectomy (prostate surgery), post-cystectomy (bladder surgery), traumatic hyphaema (bleeding inside the eye), before tooth removal (dental extraction) in hemophiliacs (people who bleed more easily than normal) and a hereditary disease called angioneurotic oedema (HANO).

Trenaxa Injection 5 ml contains an anti-fibrinolytic drug, tranexamic acid. Tranexamic acid helps the body's natural blood clotting system by reducing fibrin breakdown, which inhibits fibrinolysis, a process that limits the development of blood clots. As a result, Trenaxa Injection 5 ml contributes to the prevention of excessive bleeding.

Trenaxa Injection 5 ml is a parenteral form. It will be administered by the healthcare professional; do not self-administer. Trenaxa Injection 5 ml may cause side effects such as feeling sick (nausea), diarrhoea, vomiting, itchy skin, and pain at the injection site. These side effects usually disappear with time. However, consult your doctor immediately if these side effects persist or if you develop any other serious side effects, such as vision problems while using Trenaxa Injection 5 ml.

If you are allergic to Trenaxa Injection 5 ml or any other medicines, please inform your doctor. Inform your doctor if you have pre-existing or a history of kidney disease, disseminated intravascular coagulation (a disease where blood clots form throughout your body), thrombosis (formation of blood clots in the blood vessels) or seizures (fits), as this medicine is not recommended in such cases. Also, inform your doctor before receiving this injection if you are using any birth control pills or fibrinolytic agents (medicines that dissolve blood clots) or if you are pregnant, planning pregnancy or breastfeeding.

Uses of Trenaxa Injection 5 ml

Abnormal heavy bleeding

Directions for Use

A healthcare professional will administer the injection, so do not self-administer.

Medicinal Benefits

Trenaxa Injection 5 ml contains tranexamic acid, which is an anti-fibrinolytic medication. Tranexamic acid helps the body's natural blood clot process by preventing fibrin's breakdown, and this stops fibrinolysis, a process that stops blood clot formation. Thus Trenaxa Injection 5 ml helps to prevent excessive bleeding.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Trenaxa Injection 5 ml

  • Nausea
  • Diarrhoea
  • Itchy skin
  • Pain at the injection site
  • Injection site reactions
  • Vomiting

Drug Warnings

Before administering Trenaxa Injection 5 ml, inform your doctor if you notice blood in your urine (except during periods), or have a history of uncontrollable bleeding, disseminated intravascular coagulation (DIC) (a disease where blood clots form throughout your body), irregular periods and kidney disease. Also, inform your doctor if you or your family has a history of thrombosis (formation of blood clots in the blood vessels). Let your doctor know if you are taking medicine to treat a hereditary disease called angioneurotic oedema (HANO) every day for a long time. Your doctor may advise regular eye tests and blood tests to check your vision problems and also liver/kidney functioning. Inform your doctor if you are using birth control pills, including the patch, vaginal ring, and an intrauterine device (IUD), as there is a risk of deep vein thrombosis (a condition in which a blood clot is formed in the deeper vein, mostly the legs). Inform your doctor if you are using fibrinolytic agents (drugs that break blood clots) such as streptokinase, as they may stop the effect of Trenaxa Injection 5 ml. Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding.

Drug-Drug Interactions

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Tranexamic acidDrospirenone
Critical
Tranexamic acidLevonorgestrel
Critical

Drug-Drug Interactions

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Tranexamic acidDrospirenone
Critical
How does the drug interact with Trenaxa Injection 5 ml:
Taking drospirenone with Trenaxa Injection 5 ml may increase the risk of blood clot formation.

How to manage the interaction:
Taking Trenaxa Injection 5 ml with Drospirenone is not recommended, as it can lead to an interaction but can be taken if prescribed by the doctor. However, If you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult your doctor immediately.
Tranexamic acidLevonorgestrel
Critical
How does the drug interact with Trenaxa Injection 5 ml:
Taking Levonorgestrel with Trenaxa Injection 5 ml may increase the risk of blood clot formation which can lead to serious conditions such as heart problems and kidney failure.

How to manage the interaction:
Taking Trenaxa Injection 5 ml with Levonorgestrel may leads to an interaction but can be taken if prescribed by the doctor. However, if you experience chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Tranexamic acidEtonogestrel
Critical
How does the drug interact with Trenaxa Injection 5 ml:
Co-administration of Trenaxa Injection 5 ml may cause blood clotting when taken with Etonogestrel.

How to manage the interaction:
Taking Trenaxa Injection 5 ml with Etonogestrel is not recommended, as it can lead to an interaction but can be taken if prescribed by the doctor. However, If you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult your doctor immediately.
Tranexamic acidEthinylestradiol
Critical
How does the drug interact with Trenaxa Injection 5 ml:
Taking Ethinylestradiol with Trenaxa Injection 5 ml may increase the risk of blood clot formation.

How to manage the interaction:
Taking Ethinylestradiol with Trenaxa Injection 5 ml is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
Tranexamic acidMedroxyprogesterone
Critical
How does the drug interact with Trenaxa Injection 5 ml:
Taking Medroxyprogesterone acetate with Trenaxa Injection 5 ml may increase the risk of blood clots.

How to manage the interaction:
Taking Medroxyprogesterone with Trenaxa Injection 5 ml is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to your doctor.
Tranexamic acidEstradiol
Severe
How does the drug interact with Trenaxa Injection 5 ml:
Co-administration of Estradiol with Trenaxa Injection 5 ml can increase the risk of blood clots.

How to manage the interaction:
Taking Estradiol with Trenaxa Injection 5 ml can lead to an interaction; however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidRaloxifene
Severe
How does the drug interact with Trenaxa Injection 5 ml:
Co-administration of raloxifene with Trenaxa Injection 5 ml can increase the risk of blood clots.

How to manage the interaction:
Taking raloxifene with Trenaxa Injection 5 ml is not recommended due to its increased effects, however, it can be taken only if your doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidNorethisterone
Severe
How does the drug interact with Trenaxa Injection 5 ml:
Using Trenaxa Injection 5 ml together with norethindrone may increase the risk of blood clots.

How to manage the interaction:
Taking norethisterone with Trenaxa Injection 5 ml can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg, contact a doctor immediately .Do not discontinue any medications without consulting a doctor.
Tranexamic acidOspemifene
Severe
How does the drug interact with Trenaxa Injection 5 ml:
Co-administration of ospemifene with Trenaxa Injection 5 ml can increase the risk of blood cots.

How to manage the interaction:
Taking ospemifene with Trenaxa Injection 5 ml can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidConjugated Estrogens
Severe
How does the drug interact with Trenaxa Injection 5 ml:
Co-administration of Conjugated estrogen with Trenaxa Injection 5 ml can increase the risk of blood clots.

How to manage the interaction:
Taking Conjugated estrogen with Trenaxa Injection 5 ml may result in interaction, it can be taken only if your doctor has advised it. However, if you experience chest pain, shortness of breath, coughing up blood, or weakness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Follow a healthy diet. Include vegetables, fruits, and whole grains in your meals.
  • Stay hydrated; drink plenty of water.
  • Cut down on sugars, salts, spicy food, coffee, and alcohol.
  • A heating pad can help ease the pain by placing it on the belly or lower back.
  • Exercise can help ease the pain of menstrual cramps.
  • Avoid stress by performing meditation or yoga.
  • Massage your lower back or abdomen to relieve the pain.
  • Take proper rest.

Habit Forming

No

Therapeutic Class

ANTIFIBRINOLYTIC AGENTS

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Trenaxa Injection 5 ml contains tranexamic acid, an anti-fibrinolytic drug. Tranexamic acid helps the body's natural blood clotting mechanism by reducing fibrin breakdown, which prevents fibrinolysis, a process that prevents blood clot formation. As a result, Trenaxa Injection 5 ml helps to prevent excessive bleeding.

Taking this medication together with birth control pills may raise your chance of getting blood clots. To avoid pregnancy, use another method of birth control (such as condoms or spermicide). Consult your doctor in case of concerns.

People who have frequent nosebleeds or heavy periods can take tranexamic acid for a long time, for months or years. They normally only take it for a few days or a week at a time when the bleeding is severe. Take this medicine as your doctor prescribed.

Appropriate investigations have not revealed any geriatric-specific issues that would restrict the use of Trenaxa Injection 5 ml in the elderly. However, senior people are more prone to develop age-related renal issues. Thus, patients getting this medication should exercise caution.

Drug-Drug Interactions Checker List

  • CHLORPROMAZINE
  • TRETINOIN
  • STREPTOKINASE
  • UROKINASE
  • LEVONORGESTREL

Disease/Condition Glossary

Menorrhagia: It is a condition characterized by heavy or prolonged bleeding during menstrual periods which last for more than seven days

Epistaxis: Bleeding from the nose when the blood vessels of the nose lining burst. This can occur due to dryness or nose injury.

Post-operative bleeding: It is bleeding after surgery due to the blood vessel rupture. Some people may experience mild to severe bleeding due to cuts made during surgery.

Traumatic hyphema: It is a condition characterized by the presence of blood in the anterior chamber of the eye due to a blunt injury. This condition may also result in vision loss.

Hereditary angioneurotic oedema (HANO): Hereditary angioneurotic oedema is a hereditary disease that causes recurrent painless swelling under the skin.

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