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Reviewed By Sunny S , MBBS

About Tresiba 100U/ml Penfil Injection 3 ml

Tresiba 100U/ml Penfil Injection 3 ml belongs to a group of medication called 'anti-diabetic' primarily used for the treatment of type 1 and type 2 diabetes mellitus in both children (above 1 year of age) and adults. Diabetes is a disease where your body does not produce enough insulin to control the level of your blood sugar. Treatment with Tresiba 100U/ml Penfil Injection 3 ml helps to prevent complications from your diabetes.

Tresiba 100U/ml Penfil Injection 3 ml contains insulin degludec which is a fast-acting insulin that works rapidly to normalize blood sugar levels by helping the sugar move from the blood into other tissues of the body. It typically begins working after 60 minutes and is a long-acting insulin preparation (lasts for more than 24 hours). It prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses the production of sugar in the liver.

In patients with type 1 diabetes, Tresiba 100U/ml Penfil Injection 3 ml must be used with another type of insulin (like with short-acting insulin). On the other hand, in patients with type 2 diabetes, Tresiba 100U/ml Penfil Injection 3 ml can be used with another type of insulin or with oral antidiabetic medicines. The common side effects of Tresiba 100U/ml Penfil Injection 3 ml are hypokalaemia (low potassium), hypoglycemia (low blood sugar level), local injection site reactions, lipodystrophy (fat deposition under the skin), rash, and pruritus (itch skin) which may occur at the injection site. Most of these side effects of Tresiba 100U/ml Penfil Injection 3 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking Tresiba 100U/ml Penfil Injection 3 ml of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Do not take Tresiba 100U/ml Penfil Injection 3 ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. Along with Tresiba 100U/ml Penfil Injection 3 ml , you should take a healthy diet, do regular exercise, and maintain weight as advised by your doctor. Tresiba 100U/ml Penfil Injection 3 ml is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer of the fridge.
 

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Non returnable*
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Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Tresiba 100U/ml Penfil Injection 3 ml

Type 1 diabetes mellitus, Type 2 diabetes mellitus

Medicinal Benefits

Tresiba 100U/ml Penfil Injection 3 ml works by ensuring rapid and consistent sugar control. Tresiba 100U/ml Penfil Injection 3 ml is a long-acting synthetic form of insulin that helps lower blood sugar levels by replacing the insulin that is produced by the body naturally. This drug also helps in moving sugar from the blood into different parts of the body so that body can effectively use the sugar in producing energy. Prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses the production of sugar in the liver. Tresiba 100U/ml Penfil Injection 3 ml helps in improving the glycaemic control which in turn decreases the risk of progression of complications of diabetes like damage of retina (retinopathy), damage of kidney (nephropathy), damage of nerve cells (neuropathy), delayed wound healing, diabetic foot ulcer, and others. Besides this, Tresiba 100U/ml Penfil Injection 3 ml can be safely prescribed to the diabetic mother in the pregnancy as well as lactation stage.

Side Effects of Tresiba 100U/ml Penfil Injection 3 ml

  • Hypokalaemia (low potassium)
  • Hypoglycemia (low blood sugar level)
  • Local injection site reactions
  • Lipodystrophy (fat deposition under the skin)
  • Rash
  • Pruritus (itchy skin)

Directions for Use

Tresiba 100U/ml Penfil Injection 3 ml is for subcutaneous (under the skin) use only. However, in rare cases, it can be given via infusion intravenously under medical supervision. Wash your hands properly and adjust the dose as advised by the doctor. Clean the injection site and inject the dose subcutaneously into the abdomen area. Safely discard the needle. Your doctor will advise for how long you need to take Tresiba 100U/ml Penfil Injection 3 ml based on your medical condition.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Tresiba 100U/ml Penfil Injection 3 ml is for subcutaneous (under the skin) use only. However, in rare cases, it can be given via infusion intravenously under medical supervision. If you are changing the insulin brand or if you need to inject your insulin by another method, it should be done under strict medical supervision. Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. The first hyperglycemia symptoms (high blood sugar level) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and acetone odour of the breath. You should closely monitor these symptoms. Symptoms like heart failure, weight gain, and oedema (fluid deposition in tissue) should not be overruled. It is advisable not to consume alcohol as it may either increase or decrease your blood glucose level. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. Tresiba 100U/ml Penfil Injection 3 ml may decrease the level of potassium, leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death. Do not take Tresiba 100U/ml Penfil Injection 3 ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs.

Therapeutic Class

ANTIDIABETICS

Drug-Drug Interactions

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Insulin degludecLomefloxacin
Severe
Insulin degludecNorfloxacin
Severe

Drug-Drug Interactions

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Insulin degludecLomefloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with Lomefloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and Lomefloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Insulin degludecNorfloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with norfloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and norfloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.
Insulin degludecLevofloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Coadministration of levofloxacin and Tresiba 100U/ml Penfil Injection 3 ml can sometimes affect blood glucose levels - Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose).

How to manage the interaction:
Although using levofloxacin and Tresiba 100U/ml Penfil Injection 3 ml at the same time may cause an interaction, they can be taken together if a doctor has prescribed it. Inform doctor if you develop hypoglycemia (low blood glucose) or hyperglycemia (high blood glucose), or if you have trouble controlling your blood glucose. Hypoglycemia symptoms include headache, dizziness, tiredness, anxiety, disorientation, a shaking sensation, nausea, hunger, weakness, sweating, palpitation, and a rapid pulse. Hyperglycemia symptoms include Increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.
Insulin degludecGatifloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with Gatifloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia less frequently.

How to manage the interaction:
There could be a possible interaction between insulin aspart and Gatifloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms of hypoglycemia, which include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, or symptoms of hyperglycemia which may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Insulin degludecOfloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with ofloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and ofloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.
Insulin degludecMoxifloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with Moxifloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and Moxifloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience headache, dizziness, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, and increased urination. Do not stop using any medications without talking to a doctor.
Insulin degludecGrepafloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with grepafloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and grepafloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Insulin degludecSparfloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with sparfloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and sparfloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.
Insulin degludecEnoxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with Enoxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia(low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and cinoxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Insulin degludecTrovafloxacin
Severe
How does the drug interact with Tresiba 100U/ml Penfil Injection 3 ml :
Taking Tresiba 100U/ml Penfil Injection 3 ml with trovafloxacin affects blood glucose levels, which may cause hyperglycemia (high blood glucose) and hypoglycemia less frequently.

How to manage the interaction:
There could be a possible interaction between Tresiba 100U/ml Penfil Injection 3 ml and trovafloxacin but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • LEVOTHYROXINE SODIUM
  • METOPROLOL
  • FUROSEMIDE
  • ASPIRIN

Diet & Lifestyle Advise

  • Exercise may lower your body’s need for insulin during and for some time after the physical activity.
  • Exercise may also speed up the effect of an insulin dose, especially if the exercise involves the area of the injection site (for example, the leg should not be used for injection just prior to running). 
  • Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise. 
  • Avoid eating sugar food and prefer food cooked food low in calories.
  • When traveling across more than 2 time zones, you should talk to your doctor concerning adjustments in your insulin schedule.

Habit Forming

No

Special Advise

  • Your doctor may tell you to have a regular potassium level as prolonged administration causes a life-threatening condition of hypokalemia (low potassium). 
  • Do not mix Tresiba 100U/ml Penfil Injection 3 ml with other insulin form or dilute it.
  • Store Tresiba 100U/ml Penfil Injection 3 ml between 2-8 degree celsius temperature only. 

Disease/Condition Glossary

Type 1 diabetes mellitus: In type 1 diabetes mellitus, our body does not make insulin (the hormone which helps to decrease sugar levels in the blood) to control blood sugar levels.

Type 2 diabetes mellitus: In type 2 diabetes mellitus, either the body stops producing enough insulin, or there is resistance to the action of insulin. As a result, insulin is produced in sufficient amounts but is unable to act on the tissues of the organs.

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