Tresiba 100U/ml Penfil Injection 3 ml belongs to a group of medication called 'anti-diabetic' primarily used for the treatment of type 1 and type 2 diabetes mellitus in both children (above 1 year of age) and adults. Diabetes is a disease where your body does not produce enough insulin to control the level of your blood sugar. Treatment with Tresiba 100U/ml Penfil Injection 3 ml helps to prevent complications from your diabetes.

Tresiba 100U/ml Penfil Injection 3 ml contains insulin degludec which is a fast-acting insulin that works rapidly to normalize blood sugar levels by helping the sugar move from the blood into other tissues of the body. It typically begins working after 60 minutes and is a long-acting insulin preparation (lasts for more than 24 hours). It prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses the production of sugar in the liver.

In patients with type 1 diabetes, Tresiba 100U/ml Penfil Injection 3 ml must be used with another type of insulin (like with short-acting insulin). On the other hand, in patients with type 2 diabetes, Tresiba 100U/ml Penfil Injection 3 ml can be used with another type of insulin or with oral antidiabetic medicines. The common side effects of Tresiba 100U/ml Penfil Injection 3 ml are hypokalaemia (low potassium), hypoglycemia (low blood sugar level), local injection site reactions, lipodystrophy (fat deposition under the skin), rash, and pruritus (itch skin) which may occur at the injection site. Most of these side effects of Tresiba 100U/ml Penfil Injection 3 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking Tresiba 100U/ml Penfil Injection 3 ml of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Do not take Tresiba 100U/ml Penfil Injection 3 ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. Along with Tresiba 100U/ml Penfil Injection 3 ml , you should take a healthy diet, do regular exercise, and maintain weight as advised by your doctor. Tresiba 100U/ml Penfil Injection 3 ml is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer of the fridge.
 

Tresiba 100U/ml Penfil Injection 3 ml works by ensuring rapid and consistent sugar control. Tresiba 100U/ml Penfil Injection 3 ml is a long-acting synthetic form of insulin that helps lower blood sugar levels by replacing the insulin that is produced by the body naturally. This drug also helps in moving sugar from the blood into different parts of the body so that body can effectively use the sugar in producing energy. Prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses the production of sugar in the liver. Tresiba 100U/ml Penfil Injection 3 ml helps in improving the glycaemic control which in turn decreases the risk of progression of complications of diabetes like damage of retina (retinopathy), damage of kidney (nephropathy), damage of nerve cells (neuropathy), delayed wound healing, diabetic foot ulcer, and others. Besides this, Tresiba 100U/ml Penfil Injection 3 ml can be safely prescribed to the diabetic mother in the pregnancy as well as lactation stage.

• Hypokalaemia (low potassium)
• Hypoglycemia (low blood sugar level)
• Local injection site reactions
• Lipodystrophy (fat deposition under the skin)
• Rash
• Pruritus (itchy skin)

Tresiba 100U/ml Penfil Injection 3 ml is for subcutaneous (under the skin) use only. However, in rare cases, it can be given via infusion intravenously under medical supervision. If you are changing the insulin brand or if you need to inject your insulin by another method, it should be done under strict medical supervision. Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. The first hyperglycemia symptoms (high blood sugar level) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and acetone odour of the breath. You should closely monitor these symptoms. Symptoms like heart failure, weight gain, and oedema (fluid deposition in tissue) should not be overruled. It is advisable not to consume alcohol as it may either increase or decrease your blood glucose level. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. Tresiba 100U/ml Penfil Injection 3 ml may decrease the level of potassium, leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death. Do not take Tresiba 100U/ml Penfil Injection 3 ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs.

Drug-Drug Interaction: Tresiba 100U/ml Penfil Injection 3 ml may have an interaction with drugs that may increase the risk of antiarrhythmic (disopyramide), hemorheological agents (pentoxifylline), antidiabetic (pramlintide), bleeding disorder drugs (octreotide), antipsychotic (propoxyphene, phenothiazines), female sex hormones (progestogen, oestrogen), thyroid hormones (levothyroxine), anti-asthmatics (albuterol, epinephrine, terbutaline), an antidepressant (fluoxetine, lithium), lipid-lowering pills (reserpine, niacin, clonidine, fenofibrate, guanethidine), pain killers (aspirin), antibiotics (isoniazid), blood sugar enhancing pills (glucagon), male hormone testosterone analogue (danazol), antibiotic (pentamidine).

Drug-Food Interaction: Tresiba 100U/ml Penfil Injection 3 ml may interact with an ayurvedic, homoeopathy, Unani, herbal supplements or OTC items. Tell your doctor if you are using these products. Try to avoid alcoholic beverages with Tresiba 100U/ml Penfil Injection 3 ml as it may increase or decrease your blood sugar level.

Drug-Disease Interaction: Tresiba 100U/ml Penfil Injection 3 ml should not be given to patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycaemia), and low potassium level (hypokalaemia).

• LEVOTHYROXINE SODIUM
• METOPROLOL
• FUROSEMIDE
• ASPIRIN

• Exercise may lower your body’s need for insulin during and for some time after the physical activity.
• Exercise may also speed up the effect of an insulin dose, especially if the exercise involves the area of the injection site (for example, the leg should not be used for injection just prior to running). 
• Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise. 
• Avoid eating sugar food and prefer food cooked food low in calories.
• When traveling across more than 2 time zones, you should talk to your doctor concerning adjustments in your insulin schedule.

• Your doctor may tell you to have a regular potassium level as prolonged administration causes a life-threatening condition of hypokalemia (low potassium). 
• Do not mix Tresiba 100U/ml Penfil Injection 3 ml with other insulin form or dilute it.
• Store Tresiba 100U/ml Penfil Injection 3 ml between 2-8 degree celsius temperature only. 

Type 1 diabetes mellitus: In type 1 diabetes mellitus, our body does not make insulin (the hormone which helps to decrease sugar levels in the blood) to control blood sugar levels.

Type 2 diabetes mellitus: In type 2 diabetes mellitus, either the body stops producing enough insulin, or there is resistance to the action of insulin. As a result, insulin is produced in sufficient amounts but is unable to act on the tissues of the organs.