Trespin Respules 5 ml is an aminoglycoside antibiotic used to treat bacterial infections. It is mostly used to treat eye infections such as conjunctivitis. Besides this, it is also useful in the treatment of various bacterial infections of the brain and spinal cord (meningitis), stomach or intestines, bladder or kidney (urinary tract infection), lungs (pneumonia), and also used for infections of the bone, skin or soft tissue including burns. A bacterial infection is a condition in which bacteria grows in the body and cause infection. It can target any body part and multiply very quickly. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick.

Trespin Respules 5 ml contains tobramycin. It inhibits bacteria growth by interfering with protein synthesis. It binds to the proteins in the bacteria, disrupting the cell membrane, and eventually leading to cell death. It is active against various gram-negative bacteria and gram-positive bacteria (Staphylococcus aureus). It will not work for other types of infections such as viral, fungal, or parasitic infections.

It is available in the form of drops, ointment, injection, and inhalation. Trespin Respules 5 ml can cause some common side-effects (when eye drops are used) including redness, itching, swelling, burning sensation, tearing, and temporary blurred vision (with ointment use). Long term use of eye drops may cause a fungal eye infection. So, take this medicine for a duration prescribed by your doctor. When given as an injection, you may experience fever, rash, pain at the injection site, confusion, headache, and diarrhoea. Some patients may also experience serious side-effects such as hearing problems, muscle twitching, and convulsions that may require medical attention.

Inform your doctor if you are allergic to Trespin Respules 5 ml, other aminoglycoside antibiotics, or any other ingredients present in it. Inform your doctor if you are using other antibiotics, antifungal medication, antiviral drugs, diuretics, general anaesthetics, anti-cancer medicine, immune suppressant, and medications used to treat muscle weakness. Tell your doctor if you have myasthenia gravis (muscle disorders), Parkinson’s disease (a brain disorder), and kidney problems. Inform your doctor if you have any vision problems after using this medication. Tell your doctor if you are pregnant or breastfeeding.

Trespin Respules 5 ml belongs to a class of drugs called aminoglycoside antibiotics. It works by stopping the growth of bacteria. It reduces the infection by inhibiting bacterial growth. It irreversibly binds to a site on the bacterial ribosomes (ribosomes are responsible for protein synthesis), inhibiting protein formation. Proteins are essential for bacterial growth. So, if bacteria cannot make proteins, it will eventually die.

Trespin Respules 5 ml may show side-effects such as redness, itching, tearing, or swelling in the eye after the application of eye drops. These side-effects usually go away after a short time. With the injection, you may experience side-effects such as fever, rash, pain at the injection site, itching, fatigue, drowsiness, weakness, headache, confusion, and diarrhoea. Other side-effects of Trespin Respules 5 ml are hearing problems, dizziness, ringing in the ears, convulsions, and muscle twitching. These side-effects are serious, and you may require medical attention right away.

Inform your doctor if you are allergic to Trespin Respules 5 ml, other aminoglycoside antibiotics, or any other ingredients present in it. Inform your doctor if you are using any prescription, nonprescription medications, nutritional supplements, or herbal products. Inform your doctor if you are using other antibiotics, antifungal medication, diuretics, general anaesthetics, chemotherapeutic agents, immune suppressants, and medications used to treat muscle weakness. Inform your doctor if you have any history of myasthenia gravis, Parkinson’s diseases, kidney problems, and eye problems. Inform your doctor if you have any vision problems after using this medication. Do not drive or operate heavy machinery until your vision stabilizes. Tell your doctor if you are pregnant or breastfeeding.

Drug-drug interactions: Trespin Respules 5 ml may interact with other antibiotics (vancomycin, gentamicin, kanamycin, streptomycin, and cephalothin), diuretics (ethacrynic acid and furosemide), antifungal medication (amphotericin-B), general anesthetics, anti-cancer medicine (cisplatin), immune suppressant (ciclosporin), and medications used to treat muscle weakness (neostigmine and pyridostigmine).

Drug-food interactions: No food interactions found.

Drug-disease interactions: Trespin Respules 5 ml should be used with caution in patients with myasthenia gravis, Parkinson’s disease, and renal impairment.

• VANCOMYCIN
• KANAMYCIN
• GENTAMICIN
• STREPTOMYCIN
• FUROSEMIDE
• NEOSTIGMINE
• PYRIDOSTIGMINE
• CYCLOSPORINE
• AMPHOTERICIN B
• CISPLATIN
• CEPHALOTHIN
• ETHACRYNIC ACID

• Sleep for at least six to eight hours to rejuvenate your eyes in a natural way.
• Wash your eyes with clean water at least two to three times a day
• Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
• Keep your ear clean and dry.

Trespin Respules 5 ml may alter liver and kidney function, and blood cells count. So, laboratory tests may be performed to monitor these levels. Your doctor may also check for vision and hearing problems. 

Conjunctivitis: Conjunctivitis is an eye condition caused by infection or allergies.

Meningitis: Meningitis is an infection of the protective membranes that surround the brain and spinal cord (meninges).

Pneumonia: Pneumonia is swelling (inflammation) of the tissue in one or both lungs. It's usually caused by a bacterial infection. It can also be caused by a virus, such as a coronavirus (COVID-19).