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  3. Trilith 450mg Tablet SR

Trilith 450mg Tablet SR, Pack of 1 Tablet
Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
COD available

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Whats That

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Composition :

LITHIUM CARBONATE-450MG

Manufacturer/Marketer :

Triton Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Trilith 450mg Tablet SR

Trilith 450mg Tablet SR belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low mood depression.

Trilith 450mg Tablet SR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Trilith 450mg Tablet SR as prescribed. Your doctor will advise you on how often you need to take Trilith 450mg Tablet SR based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Trilith 450mg Tablet SR do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Trilith 450mg Tablet SR or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Trilith 450mg Tablet SR. Regular blood tests are recommended while taking Trilith 450mg Tablet SR to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or had weight loss surgery, please inform your doctor before taking Trilith 450mg Tablet SR.

Uses of Trilith 450mg Tablet SR

Bipolar disorder, Mania

Directions for Use

Take Trilith 450mg Tablet SR with food for better absorption or take it as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Trilith 450mg Tablet SR is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Trilith 450mg Tablet SR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Trilith 450mg Tablet SR relaxes nerves and calms the mood, which helps in having a better social life and enables to do daily activities comfortably.

Storage

Keep Trilith 450mg Tablet SR out of the sight and reach of children.
Side effects of Trilith 450mg Tablet SR
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Limit or eliminate caffeine and alcohol from your diet, as these substances can worsen hand trembling.
  • Practice relaxation techniques like deep breathing, yoga, or mindfulness meditation to reduce stress-induced tremors.
  • Engage in regular exercise to improve muscle control and coordination.
  • Ensure adequate sleep (7-8 hours) to prevent fatigue, which can worsen tremors.
  • Identify and minimize triggers that cause tremors, such as stress or certain activities.
  • Consider occupational therapy for tailored exercises and adaptive tools to manage daily tasks with trembling hands.
  • Consult a doctor if hand trembling interferes with your daily activities or is accompanied by other concerning neurological symptoms such as weakness, numbness, or speech difficulties.

Drug Warnings

Regular blood tests are recommended while taking Trilith 450mg Tablet SR to check lithium levels in the blood. If you are pregnant or breastfeeding, please inform your doctor before taking Trilith 450mg Tablet SR. If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Trilith 450mg Tablet SR as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

verifiedApollotooltip
LithiumCisapride
Critical
LithiumCidofovir
Critical

Drug-Drug Interactions

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LithiumCisapride
Critical
How does the drug interact with Trilith 450mg Tablet SR:
Taking Cisapride with Trilith 450mg Tablet SR can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Trilith 450mg Tablet SR with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumCidofovir
Critical
How does the drug interact with Trilith 450mg Tablet SR:
Cidofovir can cause higher levels of Trilith 450mg Tablet SR carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Trilith 450mg Tablet SR with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumDisopyramide
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking Trilith 450mg Tablet SR together with Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Trilith 450mg Tablet SR and Disopyramide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
LithiumHaloperidol
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Coadministration of Haloperidol with Trilith 450mg Tablet SR can increase the levels and risk of developing Trilith 450mg Tablet SR side effects.

How to manage the interaction:
Although taking Haloperidol and Trilith 450mg Tablet SR together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience tiredness, dizziness, confusion, difficulty breathing, an irregular heartbeat, weakness, or fever, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
LithiumAnagrelide
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking Trilith 450mg Tablet SR together with Anagrelide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Trilith 450mg Tablet SR and Anagrelide together can evidently cause an interaction, but it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
LithiumPerindopril
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Perindopril when taken together with Trilith 450mg Tablet SR may significantly increase the blood levels of Trilith 450mg Tablet SR.

How to manage the interaction:
Although there is drug interaction between perindopril and Trilith 450mg Tablet SR, but can be taken together if advised by a doctor. if experience dizziness, confusion, diarrhea, vomiting, muscle weakness, tremor (shaking of hand & legs) blurred vision, ringing in the ear, excessive thirst, and/or increased urination consult a doctor immediately. Do not discontinue medications without consulting a doctor.
LithiumEsketamine
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking Trilith 450mg Tablet SR carbonate with Esketamine can increase the risk of side effects.

How to manage the interaction:
Although taking Trilith 450mg Tablet SR and Esketamine together can evidently cause an interaction, but it can be taken if your doctor has suggested it. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination contact a doctor. Do not stop using any medications without talking to a doctor.
LithiumVortioxetine
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking Vortioxetine with Trilith 450mg Tablet SR may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Vortioxetine and Trilith 450mg Tablet SR, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumIndometacin
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking Trilith 450mg Tablet SR with indomethacin may significantly increase the blood levels of Trilith 450mg Tablet SR.

How to manage the interaction:
Taking Indometacin with Trilith 450mg Tablet SR together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience drowsiness, dizziness, confusion, diarrhoea, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and increased urination consult a doctor. Do not stop using any medications without a doctor's advice.
LithiumBepridil
Severe
How does the drug interact with Trilith 450mg Tablet SR:
Taking Trilith 450mg Tablet SR together with Bepridil can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Trilith 450mg Tablet SR and Bepridil together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a constant sodium diet as it may affect lithium levels in the blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Trilith 450mg Tablet SR.
  • Do regular exercise and maintain a stable weight as Trilith 450mg Tablet SR may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink the same amount of water every day as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Side Effects of Trilith 450mg Tablet SR

  • Loss of appetite
  • Dizziness
  • Dry mouth
  • Taste change
  • Diarrhoea
  • Blurred vision
  • Slurred speech
  • Shaky movements
  • Increased thirst and urination

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Trilith 450mg Tablet SR Substitute

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 8, 2025 | 9:44 AM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Trilith 450mg Tablet SR helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Trilith 450mg Tablet SR is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Trilith 450mg Tablet SR.

Trilith 450mg Tablet SR may cause weight gain but it is not necessary for everyone taking Trilith 450mg Tablet SR to experience this side effect. However, in order to avoid gaining weight while taking Trilith 450mg Tablet SR, you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.

It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.

Trilith 450mg Tablet SR may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong-smelling urine or a decrease in urination, it indicates that you are dehydrated, and this may affect lithium levels in the blood. Therefore, you are recommended to drink plenty of fluids while taking Trilith 450mg Tablet SR to avoid dehydration.

You are not recommended to stop taking Trilith 450mg Tablet SR without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Trilith 450mg Tablet SR for as long as your doctor has prescribed it and if you experience any difficulty while taking Trilith 450mg Tablet SR, please consult your doctor so that the dose may be gradually reduced.

You are not recommended to take Trilith 450mg Tablet SR with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking, or shivering, please consult a doctor immediately. However, before using Trilith 450mg Tablet SR with any other medicines, you are advised to contact your doctor.

Drug-Drug Interactions Checker List

  • RAMIPRIL
  • LISINOPRIL
  • METHYLDOPA
  • AMLODIPINE
  • DILTIAZEM
  • IBUPROFEN
  • DICLOFENAC
  • CELECOXIB
  • INDOMETHACIN
  • THEOPHYLLINE
  • OLANZAPINE
  • HALOPERIDOL
  • CLOZAPINE
  • SERTINDOLE
  • PHENYTOIN
  • CLONAZEPAM
  • CARBAMAZEPINE
  • QUINIDINE
  • AMIODARONE
  • PROPAFENONE
  • RANOLAZINE
  • PROCAINAMIDE
  • DISOPYRAMIDE
  • HYDROQUINIDINE
  • IBUTILIDE
  • SOTALOL
  • DOFETILIDE
  • PAROXETINE
  • AMITRIPTYLINE
  • FLUOXETINE
  • TRIMETHOPRIM
  • SPECTINOMYCIN
  • METRONIDAZOLE
  • TETRACYCLINE

Special Advise

  • Regular blood tests are advised every week while taking Trilith 450mg Tablet SR to monitor the levels of lithium in blood. When lithium levels are constant, blood tests may be done every 3 months.
  • Drink a constant amount of water daily and maintain a constant sodium intake as any major changes in these two may alter the levels of lithium in blood.

Disease/Condition Glossary

Mania: It is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Mania may occur due to lack of sleep or changes in sleep pattern, high levels of stress, and alcohol intake. Seek medical help immediately if you have any self-harming or suicidal thoughts.

Bipolar disorder: It is also called manic depression, a mental condition associated with extreme mood swings ranging from manic highs to depressive lows. The symptoms of bipolar disorder include mania (high energy and excitability) and depression (loss of interest, hopelessness, and low energy). Bipolar disorder involves lifelong treatment.

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