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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
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Not Returnable

About Triplixam 4mg/1.25mg/5mg Tablet

Triplixam 4mg/1.25mg/5mg Tablet belongs to the group of anti-hypertensive medicines used to treat high blood pressure (hypertension). High blood pressure is a condition in which the blood exerts increased pressure on the walls of blood vessels. Triplixam 4mg/1.25mg/5mg Tablet helps lower the blood pressure, thereby reduces the chances of heart problems such as heart attack and stroke.  
 
Triplixam 4mg/1.25mg/5mg Tablet contains Indapamide, Amlodipine, and Perindopril erbumine. Indapamide lowers blood pressure by increasing the amount of urine produced by the kidneys. Amlodipine relaxes the blood vessels, thereby improves blood flow. Perindopril erbumine widens the blood vessels, making it easier for the heart to pump blood through them. Together, Triplixam 4mg/1.25mg/5mg Tablet helps treat hypertension.
 
You are advised to take Triplixam 4mg/1.25mg/5mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as oedema, headache, dizziness, flushing, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Triplixam 4mg/1.25mg/5mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Triplixam 4mg/1.25mg/5mg Tablet is not recommended for breastfeeding mothers and children. Triplixam 4mg/1.25mg/5mg Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects.

Uses of Triplixam 4mg/1.25mg/5mg Tablet

Hypertension (high blood pressure).

Directions for Use

Take Triplixam 4mg/1.25mg/5mg Tablet before a meal. Swallow Triplixam 4mg/1.25mg/5mg Tablet as a whole with water; do not crush, break or chew it.

Key Benefits

Triplixam 4mg/1.25mg/5mg Tablet is a combination of three drugs, namely: Indapamide, Amlodipine, and Perindopril erbumine. Triplixam 4mg/1.25mg/5mg Tablet belongs to the group of anti-hypertensive medicines used to treat high blood pressure (hypertension). Triplixam 4mg/1.25mg/5mg Tablet helps lower blood pressure, thereby reduces the chances of heart problems such as heart attack and stroke. Indapamide is a diuretic that lowers blood pressure by increasing the amount of urine produced by the kidneys. Amlodipine is a calcium channel blocker that relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine is an angiotensin-converting enzyme inhibitor that widens the blood vessels; this makes it easier for the heart to pump blood through them. Together, Triplixam 4mg/1.25mg/5mg Tablet helps treat hypertension.

Storage

Store in a cool and dry place away from sunlight
Side effects of Triplixam 4mg/1.25mg/5mg Tablet
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Avoid triggers like alcohol, caffeine, and energy drinks.
  • Try relaxation techniques such as yoga, meditation, or deep breathing.
  • Exercise regularly as it helps maintain heart health.
  • Follow a nutritious and balanced diet.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If you suspect the medication may be affecting your vision, consult your doctor or an eye specialist.
  • Get your vision checked before and during treatment to monitor for any problems.
  • You may need to adjust or stop your medication to manage side effects.
  • Vision loss due to high pressure inside the eye (intraocular pressure) can be treated with medication or laser therapy.
  • Cataract-related vision loss may require surgery.
  • Eating a diet rich in fruits and vegetables, including carrots and dark leafy greens such as kale, spinach, and collard greens, can provide essential nutrients to help keep your eyes healthy.

Drug Warnings

Do not take Triplixam 4mg/1.25mg/5mg Tablet if you are allergic to any of its contents; if you have angioedema, severe liver/kidney problems, liver encephalopathy, severe water retention, low blood pressure, or low blood potassium. Inform your doctor if you have diabetes, heart problems, gout, parathyroid gland problems, heart failure, collagen disease, atherosclerosis (hardening of arteries), excess acid in the blood, liver/kidney problems, if you are on a low-salt diet, if you are taking lithium/potassium-sparing diuretics, low blood pressure in the brain, or if you are taking any other blood pressure-lowering medicines. Triplixam 4mg/1.25mg/5mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Triplixam 4mg/1.25mg/5mg Tablet is not recommended for breastfeeding mothers and children. Triplixam 4mg/1.25mg/5mg Tablet may cause dizziness, so drive with caution. Keep your doctor informed about your health condition and medications to rule out any interactions.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Triplixam 4mg/1.25mg/5mg Tablet:
Using Triplixam 4mg/1.25mg/5mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Triplixam 4mg/1.25mg/5mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Triplixam 4mg/1.25mg/5mg Tablet:
Combining Aliskiren with Triplixam 4mg/1.25mg/5mg Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Triplixam 4mg/1.25mg/5mg Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
IndapamideDroperidol
Critical
How does the drug interact with Triplixam 4mg/1.25mg/5mg Tablet:
Taking Droperidol with Triplixam 4mg/1.25mg/5mg Tablet can lead to severe heart problems.

How to manage the interaction:
Taking Droperidol with Triplixam 4mg/1.25mg/5mg Tablet is not recommended, but can be taken if prescribed by the doctor.
IndapamideProtriptyline
Critical
How does the drug interact with Triplixam 4mg/1.25mg/5mg Tablet:
Taking Protriptyline along with Triplixam 4mg/1.25mg/5mg Tablet can lead to serious heart problems.

How to manage the interaction:
Taking Protriptyline with Triplixam 4mg/1.25mg/5mg Tablet is not recommended, but can be taken if prescribed by the doctor.
How does the drug interact with Triplixam 4mg/1.25mg/5mg Tablet:
Taking Triplixam 4mg/1.25mg/5mg Tablet with Thioridazine can increase the risk of heart problems.

How to manage the interaction:
Taking Thioridazine with Triplixam 4mg/1.25mg/5mg Tablet is not recommended, but can be taken if prescribed by the doctor.
AmlodipineMitotane
Severe
How does the drug interact with Triplixam 4mg/1.25mg/5mg Tablet:
Using Triplixam 4mg/1.25mg/5mg Tablet and mitotane together may drastically lower Triplixam 4mg/1.25mg/5mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Triplixam 4mg/1.25mg/5mg Tablet with mitotane can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Triplixam 4mg/1.25mg/5mg Tablet:
Using phenobarbital and Triplixam 4mg/1.25mg/5mg Tablet may drastically lower Triplixam 4mg/1.25mg/5mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of phenobarbital with Triplixam 4mg/1.25mg/5mg Tablet can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Triplixam 4mg/1.25mg/5mg Tablet:
Coadministration of Triplixam 4mg/1.25mg/5mg Tablet and carbamazepine together may significantly reduce Triplixam 4mg/1.25mg/5mg Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Although there is an interaction between Triplixam 4mg/1.25mg/5mg Tablet with carbamazepine, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Triplixam 4mg/1.25mg/5mg Tablet:
Using Triplixam 4mg/1.25mg/5mg Tablet and phenytoin together may drastically lower Triplixam 4mg/1.25mg/5mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although Triplixam 4mg/1.25mg/5mg Tablet with phenytoin can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Triplixam 4mg/1.25mg/5mg Tablet:
Using Triplixam 4mg/1.25mg/5mg Tablet and primidone together may lower Triplixam 4mg/1.25mg/5mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Triplixam 4mg/1.25mg/5mg Tablet with primidone can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • You are advised to consume low salt and low-fat diet. 
  • Exercise regularly.
  • Eat a diet rich in whole grains, vegetables, and fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Practice meditation or yoga as it helps in managing stress.

Side Effects of Triplixam 4mg/1.25mg/5mg Tablet

  • Oedema
  • Headache
  • Dizziness
  • Flushing
  • Tiredness
  • Weakness
  • Nausea
  • Vomiting

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Drug-Drug Interactions Checker List

  • LITHIUM
  • DANTROLENE
  • ESTRAMUSTINE
  • SACUBITRIL+VALSARTAN
  • TRIAMTERENE
  • AMILORIDE
  • CICLOSPORIN
  • ALISKIREN

Special Advise

  • Regular monitoring of blood pressure levels, kidney function and electrolyte levels while taking Triplixam 4mg/1.25mg/5mg Tablet is advised.
  • If you are due to have any surgery, inform the doctor that you are taking Triplixam 4mg/1.25mg/5mg Tablet

Disease/Condition Glossary

High blood pressure (hypertension): It is a condition in which the blood exerts increased pressure on the walls of blood vessels leading to hypertension. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). High blood pressure also causes brain damage (stroke) and kidney failure. Symptoms of high blood pressure include headache, dizziness, nose bleed, changes in vision, chest pain, weakness and dyspnoea (shortness of breath). However, most of the time, the signs and symptoms of hypertension are none.

Have a query?

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Alcohol

Safe if prescribed

Avoid consuming alcohol as it might cause increased dizziness.

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Pregnancy

Consult your doctor

Triplixam 4mg/1.25mg/5mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Please consult your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Consult your doctor

Triplixam 4mg/1.25mg/5mg Tablet is not recommended for breastfeeding mothers. Talk to your doctor if you have any concerns.

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Driving

Safe if prescribed

Triplixam 4mg/1.25mg/5mg Tablet may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Dose adjustment may be needed. Please consult your doctor if you have liver problems or any concerns regarding this. Avoid taking Triplixam 4mg/1.25mg/5mg Tablet if you have severe liver disease or hepatic encephalopathy.

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Kidney

Consult your doctor

Dose adjustment may be needed. Avoid taking Triplixam 4mg/1.25mg/5mg Tablet if you have severe kidney problems. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Safe if prescribed

Triplixam 4mg/1.25mg/5mg Tablet is not recommended for children as safety and effectiveness have not been established.

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