Trofentyl OTFC Tablet 1's

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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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Prescription drug

Whats That

About Trofentyl OTFC Tablet

Trofentyl OTFC Tablet belongs to a class of medicines known as 'opioid analgesics,' primarily used to relieve pain. It is used to treat breakthrough pain (sudden episodes of pain occurring despite treatment with pain medication) in cancer patients. Pain can be temporary (acute) or long-lasting (chronic) in nature. Acute pain is caused by damage to the tissues of the muscle, bone, or other organs for a short time. Chronic pain lasts for a long duration and is caused due to pathologies like nerve damage and osteoarthritis.

Trofentyl OTFC Tablet contains Fentanyl. It works by blocking a chemical messenger in the brain responsible for causing pain. Hence, changing the way the brain and nervous system respond to pain.

Trofentyl OTFC Tablet should be used as recommended. Trofentyl OTFC Tablet may cause certain side effects such as dizziness, sleepiness, increased or decreased blood pressure, and irregular heartbeat in some cases. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Trofentyl OTFC Tablet should be avoided if you are allergic to opioids or any ingredients of Trofentyl OTFC Tablet. Inform your doctor before taking Trofentyl OTFC Tablet if you have respiratory disorders, heart diseases, high blood pressure, and liver or kidney disease. Avoid consuming alcohol along with Trofentyl OTFC Tablet as it could lead to increased dizziness. Do not take Trofentyl OTFC Tablet for a prolonged time as it may lead to mental or physical dependence on Trofentyl OTFC Tablet. This medicine is not recommended for children below 18 years of age. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, as it this combination may cause serious interaction. Blood pressure and cardiovascular (heart) status should be monitored closely during the treatment with Trofentyl OTFC Tablet, especially in people affected with high blood pressure and a history of heart failure.

Uses of Trofentyl OTFC Tablet

Pain relief

Directions for Use

Lozenge: Take Trofentyl OTFC Tablet as advised by your physician. Do not take more than the prescribed dose of medicine. Do not chew or break the medicine.

Medicinal Benefits

Trofentyl OTFC Tablet belongs to a class of drugs known as 'opioid analgesics,' containing Fentanyl, primarily used to relieve pain. It is used to treat breakthrough pain (sudden episodes of pain occurring despite treatment with pain medication) in cancer patients. It is also used as an anaesthetic agent for short operations and relieves pain in conditions like rheumatoid arthritis and osteoarthritis and pain affecting the joints and muscles. It works by blocking a chemical messenger in the brain responsible for causing pain. Hence, changing the way the brain and nervous system respond to pain.

Storage

Keep Trofentyl OTFC Tablet out of the sight and reach of children.

Side effects of Trofentyl OTFC Tablet

High Calcium Levels In Blood

Stay hydrated by drinking plenty of water.
Avoid dairy product such as cheese, milk, yogurt and ice cream.
Maintain healthy weight and exercise daily.
Following a low-calcium diet can help reduce hypercalcemia symptoms.

Low Levels Of Magnesium

Maintaining adequate hydration will help you control your magnesium levels and improve your general health.
Maintain a diet high in magnesium-rich foods such as spinach, almonds, chickpeas and brown rice.
Limit your alcohol intake because too much of it lowers your magnesium levels.
Plan blood testing on a regular basis to monitor magnesium levels.

Low Sodium In Blood

Consume controlled amounts of salt to raise sodium levels.
Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
Choose frozen vegetables without added butter or sauce.
Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
Avoid excessive salt intake, but allow for controlled increases as needed.
Monitor and manage underlying health conditions that may contribute to hyponatremia.

Eating Less Than Normal

Pain In Arm Or Leg

Eat fatty fish rich in omega-3 fatty acids to reduce inflammation.
Add whole grains such as brown rice, quinoa, and whole wheat bread to your diet for a nutritional boost.
Add nuts and seeds like almonds, walnuts, chia seeds for anti-inflammatory benefits.
Eat dark leafy greens like spinach, kale, collard greens for antioxidants.
Include berries like blueberries, strawberries, raspberries for anti-inflammatory properties.
Rest and take a break from usual activities.
Apply ice for 15-20 minutes, 3 times a day to reduce pain and inflammation.
Use compression with a stretchable bandage or wrap to lessen swelling and provide support.
Avoid strenuous activities and rest the affected area.
Try light stretching with gentle exercises to maintain flexibility.
Consider OTC pain medications like ibuprofen or acetaminophen but consult a doctor before taking any medication.

Involuntary Contractions Of A Muscle

Gently massage the affected area using your hands or a massager.
Light exercises such as walking or climbing stairs may help the muscles return to normal.
Apply heat/ice to the affected area.
Drink electrolyte-rich fluids.

Sore Neck

Take pain reliever medicines such as ibuprofen or paracetamol.
Apply an ice pack for 15 minutes multiple times a day during the first 48 hours. Then, use a heating pad or take warm shower.
Gently stretch the neck and massage to relieve pain.
Good posture and gentle exercise may help to prevent it.
Maintain proper sleep hygiene.

Drug Warnings

Do not take Trofentyl OTFC Tablet if you are allergic to opioids or any ingredients of Trofentyl OTFC Tablet. Inform your doctor if you have respiratory disorders, heart diseases, high blood pressure, and liver or kidney disease or hypothyroidism (underactive thyroid). Do not take Trofentyl OTFC Tablet for a prolonged time, Trofentyl OTFC Tablet contains fentanyl that may lead to mental or physical dependence on Trofentyl OTFC Tablet. Do not take Trofentyl OTFC Tablet if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. Trofentyl OTFC Tablet is not recommended for children below 18 years of age. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, as a dangerous drug interaction could occur. Trofentyl OTFC Tablet should be taken with extreme caution in patients who have a history of alcoholism or drug abuse. Avoid consuming alcohol while on this medication, as it can lead to excessive sleepiness. Blood pressure and cardiovascular (heart) status should be monitored closely during the treatment with Trofentyl OTFC Tablet, especially in people affected with high blood pressure and a history of heart failure.

Drug-Drug Interactions

FentanylMifepristone

Critical

FentanylSafinamide

Critical

Drug-Drug Interactions

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FentanylMifepristone

Critical

How does the drug interact with Trofentyl OTFC Tablet:
Taking Trofentyl OTFC Tablet and mifepristone may significantly increase the blood levels of Trofentyl OTFC Tablet, which may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between mifepristone and Trofentyl OTFC Tablet, they can be taken together if advised by a doctor. Do not stop using any medications without talking to your doctor.

FentanylSafinamide

Critical

How does the drug interact with Trofentyl OTFC Tablet:
Taking Safinamide with Trofentyl OTFC Tablet can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Trofentyl OTFC Tablet is not recommended as it can result in an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain, stomach cramps, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.

FentanylLinezolid

Critical

How does the drug interact with Trofentyl OTFC Tablet:
Taking Linezolid with Trofentyl OTFC Tablet may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is an interaction between Linezolid and Trofentyl OTFC Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, muscle pain, stomach cramps, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.

FentanylGabapentin

Severe

How does the drug interact with Trofentyl OTFC Tablet:
Taking Trofentyl OTFC Tablet with other drugs that cause central nervous system depression, such as gabapentin, might result in an increased risk of adverse effects.

How to manage the interaction:
Although combining Trofentyl OTFC Tablet and Gabapentin may cause an interaction, they can be used if advised by your doctor. Consult your doctor immediately if you feel drowsiness, trouble breathing, dizziness, or confusion. If you have any of the above symptoms, it is advised not to drive or use any hazardous machinery. Do not stop taking any medication without consulting your doctor.

FentanylSertraline

Severe

How does the drug interact with Trofentyl OTFC Tablet:
Co-administration of sertraline and Trofentyl OTFC Tablet can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of Sertraline and Trofentyl OTFC Tablet can lead to an interaction, and they can be taken together if prescribed by a doctor. However, if you experience confusion, hallucinations (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain or stiffness, stomach cramps, vomiting, or diarrhea, consult a doctor. Do not discontinue any medications without consulting a doctor.

FentanylThioridazine

Severe

How does the drug interact with Trofentyl OTFC Tablet:
Combining Thioridazine with Trofentyl OTFC Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Thioridazine and Trofentyl OTFC Tablet, you can take these medicines together if prescribed by your doctor. Consult your doctor immediately if you feel drowsiness, trouble breathing, or confusion. If you have any of the above symptoms, it is advised not to drive or use any hazardous machinery. Do not stop taking any medication without consulting your doctor.

FentanylTapentadol

Severe

How does the drug interact with Trofentyl OTFC Tablet:
Coadministration of Trofentyl OTFC Tablet with tapentadol can increase the risk of side effects such as breathing problems.

How to manage the interaction:
Although taking Trofentyl OTFC Tablet with Tapentadol can result in an interaction, they can be taken together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.

FentanylPosaconazole

Severe

How does the drug interact with Trofentyl OTFC Tablet:
Taking Trofentyl OTFC Tablet with posaconazole can raise the levels of Trofentyl OTFC Tablet in the blood and increase its effects.

How to manage the interaction:
Although taking Trofentyl OTFC Tablet together with Posaconazole can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you feel dizziness, drowsiness, or difficulty breathing. Do not stop taking any medication without consulting your doctor.

FentanylPentobarbital

Severe

How does the drug interact with Trofentyl OTFC Tablet:
Combining Pentobarbital with Trofentyl OTFC Tablet can increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Pentobarbital and Trofentyl OTFC Tablet, but it can be taken if prescribed by a doctor. Consult your doctor immediately if you feel drowsiness, trouble breathing, dizziness, or confusion. If you have any of the above symptoms, it is advised not to drive or use any hazardous machinery. Do not stop taking any medication without consulting your doctor.

FentanylArmodafinil

Severe

How does the drug interact with Trofentyl OTFC Tablet:
Taking Trofentyl OTFC Tablet and armodafinil may decreases Trofentyl OTFC Tablet levels in the blood, which may decrease the effectiveness of Trofentyl OTFC Tablet.

How to manage the interaction:
Although taking Armodafinil and Trofentyl OTFC Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience watery eyes, runny nose, fever, body aches, abdominal cramping, vomiting, or diarrhea. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscles by lifting light weights.
In the chronic condition of arthritis or joint pain, including fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that have a minimum level of chemicals called cytokines, which ramp up inflammation.
Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible, and only for a short duration of time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.
Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating many simple carbohydrates in processed foods.

Side Effects of Trofentyl OTFC Tablet

Nausea and vomiting
Muscle stiffness
Agitation
Drowsiness
Dizziness
Problems with vision
Difficulty in breathing or wheezing
Choking is caused by cramping (spasm) of the muscles in your throat
Low or high blood pressure
Irregular heartbeat (slow or fast)
Pain in your veins
Difficulty with body movements
Skin rash
Confusion after the operation

Habit Forming

No

Therapeutic Class

NARCOTIC (OPIOID) ANALGESIC

Author Details

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:47 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Trofentyl OTFC Tablet work?

Trofentyl OTFC Tablet contains Fentanyl which works by blocking a chemical messenger in the brain responsible for causing pain. Hence, changing the way the brain and nervous system respond to pain.

Can use of Trofentyl OTFC Tablet cause breathing problem?

Yes, Trofentyl OTFC Tablet sometimes may make you breathe more slowly than usual or can cause shortness of breath. If you feel so, please inform your doctor immediately. Also, people with any breathing problems should inform their doctor before starting Trofentyl OTFC Tablet.

Is Trofentyl OTFC Tablet safe for the elderly?

Elderly patients (aged more than 65 years) are more likely to have confusion and sleepiness or age-related health issues, which may require caution and an adjustment in the dose for patients taking Trofentyl OTFC Tablet. So, it is better to consult a doctor before taking this medicine.

Trofentyl OTFC Tablet is a habit-forming drug, so will I get addicted to it?

Trofentyl OTFC Tablet is a habit-forming drug. It is not likely to be addictive if you take it for 2-4 weeks. However, if the doctor has prescribed you for more than 2-4 weeks, your doctor may reduce your dose before completely stopping it.

What will happen if suddenly stopped taking Trofentyl OTFC Tablet?

Do not stop taking Trofentyl OTFC Tablet until instructed by your doctor. You may get side effects like confusion, depression, nervousness, sweating, and diarrhoea. Your doctor may lower the dose of Trofentyl OTFC Tablet if using it for more than 2-4 weeks of treatment to reduce side effects.

Drug-Drug Interactions Checker List

CETIRIZINE
PHENYLEPHRINE
RITONAVIR
PAROXETINE
FLUCONAZOLE
VORICONAZOLE
ESCITALOPRAM
CITALOPRAM

Special Advise

Regular monitoring of blood pressure and heart rate is required while taking Trofentyl OTFC Tablet.
Trofentyl OTFC Tablet causes drowsiness. Avoid doing activities that require complete focus and attention.
An abrupt stoppage of Trofentyl OTFC Tablet can lead to significant withdrawal symptoms. Always discuss with your doctor about decreasing the dosage before completely stopping its usage.
Avoid consuming alcohol while on this medication, as it can lead to dangerous side effects.
Trofentyl OTFC Tablet is unsafe for usage if you're pregnant or are planning to get pregnant. Discuss with your doctor in such situations about changing/replacing the medicine with safer alternatives.
To avoid getting addicted to this drug, take it in prescribed quantities and as directed by your doctor. Do not self-medicate.
Trofentyl OTFC Tablet should not be administered during labour as it may affect the baby’s breathing.

Disease/Condition Glossary

Pain: It can be short-term (acute) or long-term (chronic) in nature. Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone, or organs. Chronic pain lasts for a longer duration and is caused due to pathologies like nerve damage, osteoarthritis, and dental pain due to damage to the tooth nerve, infection, decay, extraction, or injury. Many women have painful periods known as dysmenorrhea, most often menstrual cramps. On the other hand, Osteoarthritis is a degenerative disease that results in chronic pain in joints (especially knee) and stiffness, making daily tasks difficult.