Trypentin-At Tab 10'S

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

MRP ₹200

(Inclusive of all Taxes)

₹30.0 Cashback (15%)

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Non returnable*

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COD available

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Prescription drug

Whats That

About Trypentin-At Tab

Trypentin-At Tab is a combination medicine indicated for the management of neuropathic pain. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain due to damaged sensory nerves. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful).

Trypentin-At Tab is a combination of two drugs: Gabapentin (anti-convulsant) and Amitriptyline (tricyclic antidepressant). Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps relieve nerve pain. Amitriptyline works by increasing the serotonin and noradrenaline (natural substances) levels in the brain, thereby preventing the movement of pain signals in the brain. Together, Trypentin-At Tab helps in providing relief from neuropathic pain.

You are advised to take Trypentin-At Tab for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, sleepiness, tiredness, headache, nausea, vomiting, blurred vision, and dry mouth. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Trypentin-At Tab may cause drowsiness and dizziness, so drive only if you are alert. Please consult your doctor if you have any concerns regarding the usage of Trypentin-At Tab in children. Avoid consuming alcohol along with Trypentin-At Tab as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of Trypentin-At Tab

Neuropathic pain

Directions for Use

Take Trypentin-At Tab with or without food. Swallow Trypentin-At Tab as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Trypentin-At Tab is a combination of two drugs: Gabapentin and Amitriptyline. Gabapentin belongs to a class of drugs called anti-convulsants whereas Amitriptyline belongs to tricyclic antidepressants. Trypentin-At Tab is used to treat neuropathic pain. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps relieve nerve pain. Amitriptyline works by increasing the level of chemical messengers such as noradrenaline and serotonin, thereby preventing the movement of pain signals in the brain. Together, Trypentin-At Tab helps in providing relief from neuropathic pain.

Storage

Keep Trypentin-At Tab out of reach and sight of children.

Side effects of Trypentin-At Tab

Uncoordinated Muscle Movements

Uncoordinated muscle movements need immediate medical attention.
Observe your movements and try to understand and control the particular movement.
Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
Implement massage techniques to enhance blood flow to organs.
Take a balanced diet and quit smoking.
Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.

Delayed Electrical Conduction Between The Atria And Ventricles

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Aggression

Try to practice deep breathing exercises or repeat calming words or phrases.
Seek for medical help if aggression occurs frequently, as it can worsen gradually if not attended.
You can also try listening to music or relaxing or writing a journal to express the feeling that aggravates to find a solution.

Low Sodium In Blood

Consume controlled amounts of salt to raise sodium levels.
Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
Choose frozen vegetables without added butter or sauce.
Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
Avoid excessive salt intake, but allow for controlled increases as needed.
Monitor and manage underlying health conditions that may contribute to hyponatremia.

Impotence

Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
Maintain a healthy weight as overweight can cause erectile dysfunction.
Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
Consume a healthy diet loaded with whole grains, fruits and vegetables.
Limit alcohol consumption as excessive alcohol intake can impair erectile function.
Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
Openly discuss your concerns with your partner.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Drug Warnings

Do not take Trypentin-At Tab if you are allergic to any of its contents; if you recently had a heart attack, if you have heart rhythm problems, severe liver disease or if you are taking monoamine oxidase inhibitors (MAOI) or have taken them in the last 14days. Inform your doctor if you have/had heart, kidney or liver problems, nervous system disorders, respiratory disorders, or muscle weakness. Consult your doctor if you are pregnant or breastfeeding. Trypentin-At Tab may cause drowsiness, dizziness and blurred vision, so drive only if you are alert. Avoid consuming alcohol along with Trypentin-At Tab as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Drug-Drug Interactions

AmitriptylinePimozide

Critical

AmitriptylineThioridazine

Critical

Drug-Drug Interactions

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AmitriptylinePimozide

Critical

How does the drug interact with Trypentin-At Tab:
Combining Trypentin-At Tab and Pimozide may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Trypentin-At Tab with Pimozide may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.

AmitriptylineThioridazine

Critical

How does the drug interact with Trypentin-At Tab:
Trypentin-At Tab and Thioridazine can enhance each other's effects when used together.

How to manage the interaction:
Although using Trypentin-At Tab and Thioridazine together can cause an interaction, they can be used if prescribed by a doctor. If you have extreme sleepiness, confusion, anxiety, vomiting, vision problems, feeling hot or cold, sweating, muscle stiffness, fainting, fits, or coma, seek medical help. Do not discontinue any medications without consulting a doctor.

AmitriptylineSaquinavir

Critical

How does the drug interact with Trypentin-At Tab:
Combining Trypentin-At Tab and Saquinavir may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Trypentin-At Tab with Saquinavir may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.

AmitriptylineSelegiline

Critical

How does the drug interact with Trypentin-At Tab:
Co-administration of Trypentin-At Tab together with Selegiline can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a mood stabilizer).

How to manage the interaction:
Although using Selegiline and Trypentin-At Tab together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Trypentin-At Tab. Do not discontinue any medications without consulting a doctor.

AmitriptylinePotassium chloride

Critical

How does the drug interact with Trypentin-At Tab:
The combination of Trypentin-At Tab and Potassium chloride may cause stomach and upper intestinal discomfort. (Only applicable to an oral preparation)

How to manage the interaction:
Although co-administration of Trypentin-At Tab and Potassium chloride is not recommended as it can possibly lead to an interaction, they can be taken if prescribed by a doctor. If you experience severe stomach pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (in particular with blood), decreased hunger, and black stools while taking these medications, consult a doctor immediately. Do not discontinue any medications without talking to a doctor.

AmitriptylineMesoridazine

Critical

How does the drug interact with Trypentin-At Tab:
Coadministration of Trypentin-At Tab and Mesoridazine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Trypentin-At Tab with Mesoridazine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.

AmitriptylineMethylene blue

Critical

How does the drug interact with Trypentin-At Tab:
Combining Methylene blue with Trypentin-At Tab can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Methylene blue and Trypentin-At Tab together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Trypentin-At Tab. Do not discontinue any medications without consulting a doctor.

AmitriptylinePhenelzine

Critical

How does the drug interact with Trypentin-At Tab:
Using Trypentin-At Tab together with Phenelzine can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Phenelzine and Trypentin-At Tab together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Trypentin-At Tab. Do not discontinue any medications without consulting a doctor.

AmitriptylineLinezolid

Critical

How does the drug interact with Trypentin-At Tab:
Taking Linezolid with Trypentin-At Tab can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Linezolid and Trypentin-At Tab together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Trypentin-At Tab. Do not discontinue any medications without consulting a doctor.

AmitriptylineZiprasidone

Critical

How does the drug interact with Trypentin-At Tab:
Taking Trypentin-At Tab and Ziprasidone may increase the risk of irregular heartbeat.

How to manage the interaction:
Although there is a interaction between Trypentin-At Tab with Ziprasidone, but it can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats . Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Include food rich in vitamin B and D in your diet.
Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
Exercising regularly helps in improving overall health and combating pain.
Rest well, get plenty of sleep.
Try taking a warm bath, as it can be soothing.
Avoid smoking and alcohol consumption.
Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
Acupuncture can be helpful by stimulating pressure points.
Using essential oils for massages can help increase circulation.

Side Effects of Trypentin-At Tab

Dizziness
Sleepiness
Tiredness
Headache
Nausea
Vomiting
Dry mouth

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:33 AM IST

We provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Trypentin-At Tab work?

Trypentin-At Tab contains Gabapentin and Amitriptyline. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps relieve nerve pain. Amitriptyline works by increasing the level of chemical messengers such as noradrenaline and serotonin, thereby preventing the movement of pain signals in the brain. Together, Trypentin-At Tab helps in providing relief from neuropathic pain.

Can I stop taking Trypentin-At Tab if I feel well?

To treat your condition effectually, continue taking Trypentin-At Tab for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Trypentin-At Tab .

Is Trypentin-At Tab used to treat peripheral neuropathy?

Trypentin-At Tab is used to treat peripheral neuropathic pain caused due to disease conditions such as diabetes or shingles (viral infection). Peripheral neuropathy occurs due to damaged peripheral nerves.

How to cope with dry mouth?

Dry mouth could be a side-effect of Trypentin-At Tab . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Is it safe to take Trypentin-At Tab if I have heart problems?

Do not take Trypentin-At Tab if you recently had a heart attack. Consult your doctor before taking Trypentin-At Tab if you have any heart problems.

Drug-Drug Interactions Checker List

ZOLPIDEM
DULOXETINE
ESCITALOPRAM
SERTRALINE
HYDROCODONE
ACETAMINOPHEN
DIPHENHYDRAMINE
CETIRIZINE
CYCLOBENZAPRINE
PREGABALIN
TOPIRAMATE
LEVOTHYROXINE
ALPRAZOLAM
QUETIAPINE

Disease/Condition Glossary

Neuropathic pain: Neuropathic pain is caused due to damaged sensory nerves. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury; the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful).