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  3. TYROGEF 250MG TABLET

TYROGEF 250MG TABLET, Pack of 10 TABLETS
Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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Whats That

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Composition :

GEFITINIB-250MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About TYROGEF 250MG TABLET

TYROGEF 250MG TABLET belongs to the group of medicine called ‘anti-cancer’, primarily indicated in lung cancer treatment. Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. These abnormal cells do not carry out normal lung cell functions and do not develop into healthy lung tissue. In this disease, cells of the lung grow uncontrollably, and if not detected at an early stage may spread to other body parts, including the brain.

TYROGEF 250MG TABLET contains 'Gefitinib' which belongs to the group of medicines known as 'kinase inhibitors'. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Take TYROGEF 250MG TABLET as prescribed by your doctor. You are suggested to take TYROGEF 250MG TABLET as long as your doctor has prescribed it after checking your medical condition.  In some cases, you may experience certain common side effects such as itching or skin rash, acne, nail problems, vomiting, diarrhea, and loss of appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking TYROGEF 250MG TABLET for as long as your doctor has prescribed. Do not take TYROGEF 250MG TABLET if you are pregnant or planning for pregnancy as TYROGEF 250MG TABLET causes serious birth defects. TYROGEF 250MG TABLET should not be taken by breastfeeding mothers as it passes into breast milk and may cause a possible risk to the infant. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition. Avoid consuming alcohol along with TYROGEF 250MG TABLET as it could lead to increased dizziness.

Uses of TYROGEF 250MG TABLET

Non-small cell lung cancer

Directions for Use

TYROGEF 250MG TABLET can be taken without food on an empty stomach at least one or two hours before taking a meal. Swallow it as a whole with water; do not crush, break or chew it. Do not drink any liquid other than water to swallow the medicine.

Medicinal Benefits

TYROGEF 250MG TABLET is indicated to the patients dealing with non-small cell lung cancer. Cancer of this type tends to spread quickly in other parts of the body. TYROGEF 250MG TABLET travels through the bloodstream and effectively destroys cancerous cells of the lung and other parts of the body. TYROGEF 250MG TABLET is a ' tyrosine kinase inhibitor (TKI)', that stops the uncontrolled growth and spread of cancerous cells.  It acts by stopping the abnormal protein action that is responsible for the multiplication of cancerous cells. Whenever a new healthy cell is formed, it undergoes a usual process of maturity. Cancerous cells form new cells more quickly, so TYROGEF 250MG TABLET targets cancerous cells and blocks the action of Tyrosine kinase enzymes (responsible for causing cancer). It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, TYROGEF 250MG TABLET stops the production, spread and growth of cancerous cells in the body.

Storage

Keep TYROGEF 250MG TABLET out of reach and sight of children.
Side effects of Tyrogef 250mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Inflammation in the lungs needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Intake of cod liver oil can smoothen the functioning of the body process.
  • Rest and refrain from physical activity, and restart after a few days.
  • Avoid smoking as it can worsen the swelling.
  • Practice meditation and yoga to enhance lung efficiency gradually after consulting with your doctor.

Drug Warnings

Tell your doctor if you have liver or kidney disease, vision problems, breathing problems or taking any blood thinner like warfarin. Before undergoing any surgery, it is advised to tell the medical professional who performs the procedure about all the medicines you are taking. Some persons may experience diarrhoea as a side effect of TYROGEF 250MG TABLET, so it is advised to drink a lot of water and tell your doctor in such a case. Inform your doctor if you notice any severe side effects of TYROGEF 250MG TABLET, including shortness of breath, worsening cough, and other vision problems. You need to go to regular blood tests to check if this medicine is working fine for you.  Avoid high-fibre foods, raw fruits, cereals, vegetables, and drink lots of water as TYROGEF 250MG TABLET may cause diarrhoea. 

Drug-Drug Interactions

verifiedApollotooltip
GefitinibThioridazine
Critical
GefitinibPhenobarbital
Severe

Drug-Drug Interactions

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GefitinibThioridazine
Critical
How does the drug interact with Tyrogef 250mg Tablet:
When Tyrogef 250mg Tablet is taken with Thioridazine it can increase the levels of Thioridazine in the body. This increases the risk or severity of side effects in the body.

How to manage the interaction:
Co-administration of Tyrogef 250mg Tablet with Thioridazine is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms, such as sudden dizziness, lightheadedness, fainting, trouble breathing, or experiencing heart palpitations, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GefitinibPhenobarbital
Severe
How does the drug interact with Tyrogef 250mg Tablet:
Phenobarbital can drastically lower Tyrogef 250mg Tablet levels in the blood, making the medicine less effective.

How to manage the interaction:
Although taking phenobarbital with Tyrogef 250mg Tablet can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
GefitinibSodium bicarbonate
Severe
How does the drug interact with Tyrogef 250mg Tablet:
Taking Sodium bicarbonate with Tyrogef 250mg Tablet together can reduce the levels and treatment outcomes of Tyrogef 250mg Tablet.

How to manage the interaction:
Although taking Tyrogef 250mg Tablet and Sodium bicarbonate together can cause an interaction, it can be taken if a doctor has suggested it. Contact your doctor if your symptoms do not improve. Do not stop using any medications without talking to a doctor.
GefitinibTeriflunomide
Severe
How does the drug interact with Tyrogef 250mg Tablet:
Tyrogef 250mg Tablet can cause higher levels of Teriflunomide in the blood by reducing its excretion rate.

How to manage the interaction:
Co-administration of Tyrogef 250mg Tablet with Teriflunomide can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding. Do not discontinue any medications without consulting a doctor.
GefitinibRabeprazole
Severe
How does the drug interact with Tyrogef 250mg Tablet:
Taking Rabeprazole together with Tyrogef 250mg Tablet results in decreased levels of Tyrogef 250mg Tablet in your blood. This can result in a decreased effectiveness of Tyrogef 250mg Tablet in treating the disease.

How to manage the interaction:
Although taking Rabeprazole and Tyrogef 250mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. To lessen the effects of the interaction, it is advised that you take Tyrogef 250mg Tablet 12 hours before or 12 hours after rabeprazole. Do not discontinue any medications without a doctor's advice.
GefitinibNizatidine
Severe
How does the drug interact with Tyrogef 250mg Tablet:
Nizatidine can make Tyrogef 250mg Tablet less effective by reducing its absorption and lowering its concentration in the blood. This decreases the treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Tyrogef 250mg Tablet and Nizatidine, you can take these medicines together if prescribed by your doctor. It is recommended that you take Tyrogef 250mg Tablet 6 hours before or 6 hours after nizatidine to help minimize the impact of the interaction. Do not stop using any medications without talking to a doctor.
GefitinibRanitidine bismuth citrate
Severe
How does the drug interact with Tyrogef 250mg Tablet:
Coadministration of Tyrogef 250mg Tablet and Ranitidine bismuth citrate can reduce the absorption and decrease the levels of Ranitidine bismuth citrate in the body.

How to manage the interaction:
There may be a possibility of interaction between Tyrogef 250mg Tablet and Ranitidine bismuth citrate, but it can be taken if prescribed by a doctor. It is recommended to take Tyrogef 250mg Tablet 6 hours before or 6 hours after Ranitidine bismuth citrate to help minimize the impact of the interaction. Do not stop using any medications without talking to a doctor.
GefitinibLansoprazole
Severe
How does the drug interact with Tyrogef 250mg Tablet:
Co-administration of Lansoprazole with Tyrogef 250mg Tablet may interfere with the absorption of Tyrogef 250mg Tablet and reduce its effectiveness.

How to manage the interaction:
Although taking Lansoprazole and Tyrogef 250mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. To decrease the effects of the interaction, it is advised to take Tyrogef 250mg Tablet either 12 hours before or 12 hours after lansoprazole. Do not discontinue any medications without a doctor's advice.
GefitinibMagnesium hydroxide
Severe
How does the drug interact with Tyrogef 250mg Tablet:
Taking Tyrogef 250mg Tablet with magnesium hydroxide can reduce the effectiveness of Tyrogef 250mg Tablet

How to manage the interaction:
Although taking Dolutegravir and Tyrogef 250mg Tablet together can possibly result in an interaction, they can be taken together if prescribed by your doctor. In case you experience any unusual side effects, consult a doctor. Do not discontinue using any medications without consulting a doctor.
GefitinibEnzalutamide
Severe
How does the drug interact with Tyrogef 250mg Tablet:
Coadministration of Tyrogef 250mg Tablet with Enzalutamide can alter the blood levels of Tyrogef 250mg Tablet which can lead to poor treatment outcomes.

How to manage the interaction:
Taking Tyrogef 250mg Tablet with Enzalutamide together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles reduce fatigue, helps in weight loss, and give strength. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga and other relaxation techniques may also improve physical and mental health and may reduce your stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting helps in improving your health, mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains,  nuts, and seeds.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

TYROGEF 250MG TABLET Substitute

Substitutes safety advice

Product Substitutes

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

It usually takes three to six months for most types of lung cancer to double their size. It took many years for lung cancer to reach a size that could be diagnosed in X-Ray.

The most common sign of lung cancer is a cough that lasts long and gets worse with time. Sometimes, a patient may notice blood in the cough. Chest pain is also a sign of lung cancer followed by coughing.

TYROGEF 250MG TABLET may affect the ability of women to have a child. Thus it is advised to tell your doctor if you have such a plan.

It is suggested to avoid taking an antacid or stomach acid-reducing medicine within 6 hours after taking TYROGEF 250MG TABLET as it may make the medicine less effective if taken simultaneously.

TYROGEF 250MG TABLET is safe to be taken by a diabetic person. However, take TYROGEF 250MG TABLET only after asking with a doctor as they may adjust the dosing according to the patient's condition.

TYROGEF 250MG TABLET is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least 6 months after taking the last dose of TYROGEF 250MG TABLET.

TYROGEF 250MG TABLET should be stopped in cases where a person faces a serious side effect that affects life quality. Otherwise, it would be best if you kept taking TYROGEF 250MG TABLET until your doctor asks you to stop it.

Drug-Drug Interactions Checker List

  • SORAFENIB
  • PACLITAXEL
  • NEOMYCIN
  • CARBAMAZEPINE
  • PHENYTOIN
  • IBUPROFEN
  • NAPROXEN
  • WARFARIN
  • OMEPRAZOLE

Special Advise

  • It is suggested to avoid taking an antacid or stomach acid-reducing medicine within 6 hours after taking TYROGEF 250MG TABLET as it may make the medicine less effective if taken simultaneously. 
  • Your doctor may suggest periodic liver function test to monitor the function of the liver due to the use of TYROGEF 250MG TABLET.

Disease/Condition Glossary

Lung cancer: It happens when cells in the lung begin to grow in an uncontrolled manner. The most common form of lung cancer is non-small cell lung cancer (NSCLC). It happens when cells that form the lining of the lung start growing uncontrollably. Persons who smoke are at high risk of lung cancer. A common symptom of NSCLC is a cough that does not go easily followed by shortness of breath. Cancerous cells of the lung spread off and travel through the bloodstream to distant regions of the body and grow.

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