Tysabri 300 mg Injection 15 ml

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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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Whats That

About Tysabri 300 mg Injection

Tysabri 300 mg Injection belongs to the class of monoclonal antibodies. It is used in the treatment of multiple sclerosis (a condition in which the immune system attacks the protective covering of the nerves called myelin, causing disrupted communication between the brain and body) and moderately to severe Crohn’s disease (a chronic bowel disease that affects any part of the gastrointestinal tract, mainly small and large intestine) in patients who are unable to tolerate conventional Crohn’s disease therapy and inhibitors of TNF-α.

Tysabri 300 mg Injection consists of Natalizumab, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation.

Tysabri 300 mg Injection may cause certain side effects, such as nausea, headache, fever, joint pain, upper respiratory tract infections, abdominal discomfort, diarrhoea, tiredness, back pain, itching, depression, and injection site reactions. Most of these side effects do not require medical attention. However, if these side effects persist, please consult your doctor. Tysabri 300 mg Injection will be administered by a trained healthcare doctor. Hence, do not self-administer.

Tysabri 300 mg Injection should be avoided if you are allergic to any of its components. Inform your doctor if you have any history of serious infections, tuberculosis, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Tysabri 300 mg Injection is contraindicated in patients with Progressive Multifocal Leukoencephalopathy (PML), as it can cause serious adverse effects. Consult the doctor if you are pregnant or breastfeeding.

Uses of Tysabri 300 mg Injection

Multiple sclerosis, Crohn’s disease.

Directions for Use

Tysabri 300 mg Injection will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Tysabri 300 mg Injection consists of Natalizumab, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation. This causes inhibition and alters the gene expression of blood monocytes and thus helps reduce inflammation of the bowel disease. It is used in the treatment of moderately to severe Crohn’s disease and multiple sclerosis.

Storage

Keep Tysabri 300 mg Injection out of the sight and reach of children.

Side effects of Tysabri 300 mg Injection 15 ml

Progressive Multifocal Leukoencephalopathy

Allergic Reactions

Managing Medication-Related Skin Allergies: A Step-by-Step Guide

If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
Your doctor may recommend or prescribe drugs to relieve discomfort.
Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
Staying hydrated by consuming plenty of water can help relieve discomfort.
Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Weakened Immune System

Your doctor may adjust the dose of the suspected medication based on your immune health; however, do not stop taking it suddenly without consulting them first.
Wash your hands often and handle food safely to avoid germs.
Get enough sleep and manage your stress levels to help your immune system stay strong.
Eat a balanced diet with plenty of vegetables, fruits, whole grains, dairy, and proteins.
Do not eat raw eggs, meat, fruits, unpasteurized milk, or uncooked vegetables.
Stay away from crowded places and individuals who are sick.
Have regular blood tests to check your immune system’s health.
Keep your vaccines up-to-date and ask your doctor about which vaccines you need.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Joint Pain

Here are the steps to manage Joint Pain caused by medication usage:

Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

Drug Warnings

Inform your doctor if you have any history of serious infections, tuberculosis, liver, or kidney diseases, or a weak immune system, as it can worsen your health condition. This medicine is contraindicated in patients with leukemia or lymphoma, or an organ transplant as it can cause life-threatening conditions. Tysabri 300 mg Injection may cause serious reactions including infusion-related or allergic reactions. This medicine may also increase the risk of serious infections and hypersensitivity reactions in some patients. Hence, patients should be carefully monitored for any changes during and after the treatment course. Tysabri 300 mg Injection is not recommended for use in children below 18 years of age as safety and efficacy are not established. This medicine can cause Progressive Multifocal Leukoencephalopathy (PML) in most patients with compromised immune system. The chance of getting PML is more if the patient is exposed to John Cunningham Virus, if received Tysabri 300 mg Injection for longer than 2 years or treated with other medicine that weakens your immune system. Hence it is important to inform your doctor about your complete medication history and previous medical history before receiving Tysabri 300 mg Injection.

Drug-Drug Interactions

NatalizumabPazopanib

Severe

NatalizumabGemcitabine

Severe

Drug-Drug Interactions

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NatalizumabPazopanib

Severe

How does the drug interact with Tysabri 300 mg Injection 15 ml:
Taking Pazopanib with Tysabri 300 mg Injection 15 ml can increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Pazopanib and Tysabri 300 mg Injection 15 ml, but it can be taken if your doctor has advised it. However, consult your doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

NatalizumabGemcitabine

Severe

How does the drug interact with Tysabri 300 mg Injection 15 ml:
Combining Gemcitabine with Tysabri 300 mg Injection 15 ml can increase the risk of side effects.

How to manage the interaction:
Co-administration of Gemcitabine with Tysabri 300 mg Injection 15 ml can result in an interaction, but it can be taken if your doctor has advised it. If you experience any symptoms such as fever, diarrhea, sore throat, muscle aches, or vision changes, contact a doctor right away. Do not discontinue any medications without consulting a doctor.

NatalizumabLenalidomide

Severe

How does the drug interact with Tysabri 300 mg Injection 15 ml:
Combining Lenalidomide with Tysabri 300 mg Injection 15 ml can increase the chances of experiencing harmful side effects.

How to manage the interaction:
Although there is a possible interaction between Lenalidomide and Tysabri 300 mg Injection 15 ml, you can take these medicines together if prescribed by your doctor. If you experience symptoms like infection, neurological problems, fever, diarrhea, or confusion, contact your doctor immediately. Do not stop using any medications without a doctor's advice.

NatalizumabMercaptopurine

Severe

How does the drug interact with Tysabri 300 mg Injection 15 ml:
Co-administration of Mercaptopurine with Tysabri 300 mg Injection 15 ml can increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Mercaptopurine and Tysabri 300 mg Injection 15 ml, you can take these medicines together if prescribed by a doctor. If you experience symptoms like fever, muscle aches, or confusion, contact a doctor right away. Do not stop using any medications without talking to a doctor.

NatalizumabDasatinib

Severe

How does the drug interact with Tysabri 300 mg Injection 15 ml:
Using Tysabri 300 mg Injection 15 ml together with Dasatinib may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Tysabri 300 mg Injection 15 ml and Dasatinib, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms - fever, muscle aches, difficulty breathing, pain or burning while urinating - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.

NatalizumabAzathioprine

Severe

How does the drug interact with Tysabri 300 mg Injection 15 ml:
Taking Azathioprine with Tysabri 300 mg Injection 15 ml can raise the risk of severe infections.

How to manage the interaction:
Although taking Azathioprine and Tysabri 300 mg Injection 15 ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm(a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory and personality, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.

NatalizumabEverolimus

Severe

How does the drug interact with Tysabri 300 mg Injection 15 ml:
Using Tysabri 300 mg Injection 15 ml together with everolimus, or using them sequentially with little to no time in between, may increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Everolimus and Tysabri 300 mg Injection 15 ml, but it can be taken if prescribed by a doctor. Inform a doctor if you have a fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. consult a doctor immediately, if you experience progressive weakening on one side of your body, clumsiness of limbs, visual disturbance, disorientation, or changes in your thinking, memory, or personality. Do not stop using any medications without talking to a doctor.

NatalizumabNilotinib

Severe

How does the drug interact with Tysabri 300 mg Injection 15 ml:
Combining Tysabri 300 mg Injection 15 ml and nilotinib can increase the risk of serious infections and progressive multifocal leukoencephalopathy (a disease of the white matter of the brain, caused by a virus infection (polyomavirus JC) that targets cells that make myelin—the material that insulates nerve cells (neurons)).

How to manage the interaction:
Taking Tysabri 300 mg Injection 15 ml and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory and personality, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

NatalizumabRuxolitinib

Severe

How does the drug interact with Tysabri 300 mg Injection 15 ml:
Taking Ruxolitinib together with Tysabri 300 mg Injection 15 ml may increase the risk of infections.

How to manage the interaction:
Although taking Ruxolitinib and Tysabri 300 mg Injection 15 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.

NatalizumabMycophenolate Mofetil

Severe

How does the drug interact with Tysabri 300 mg Injection 15 ml:
Using Tysabri 300 mg Injection 15 ml together with mycophenolate mofetil may increase the risk of developing serious infections.

How to manage the interaction:
Although taking Mycophenolate Mofetil and Tysabri 300 mg Injection 15 ml together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination call a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help heal faster.
Eat more fibre-rich foods such as fruits and vegetables.
Eat smaller meals all day and drink small amounts of water throughout the day.
If you are intolerant to lactose, lower your intake of milk.
Avoid foods high in sugar, fat, and processed foods, as these may cause inflammation.
Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.
Try to stay active. Choose moderate exercises.
Prevent stress by doing meditation or yoga.

Side Effects of Tysabri 300 mg Injection

Injection site reactions
Headache
Nausea
Upper respiratory tract infections.
Joint pain
Tiredness
Cough
Back pain
Itching
Diarrhoea
Depression

Habit Forming

No

Therapeutic Class

MONOCLONAL ANTIBODIES

Author Details

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Tysabri 300 mg Injection work?

Tysabri 300 mg Injection works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation. This alters the gene expression of blood monocytes and thus helps reduce inflammation.

Before receiving Tysabri 300 mg Injection, what should be informed to my healthcare provider?

Inform your doctor about your complete medical and medication history especially, if you have any history of serious infections, tuberculosis, liver or kidney diseases, or a weak immune system, as it can worsen your health condition.

Drug-Drug Interactions Checker List

INFLIXIMAB
ETANERCEPT
ADALIMUMAB
GOLIMUMAB
GLATIRAMER
INTERFERON BETA 1A
DOXORUBICIN
EPIRUBICIN
MERCAPTOPURINE
METHYLPREDNISOLONE
DEXAMETHASONE
PREDNISOLONE

Special Advise

It is advised to closely monitor the patient for infections like active tuberculosis, and HIV infection during and after the treatment.
It is essential to inform your doctor if you have any active viral, bacterial, and fungal infections before starting Tysabri 300 mg Injection.
Tysabri 300 mg Injection is used to treat the condition but does not cure it.
This medicine is administered only once every four weeks by a trained oncologist.
Tysabri 300 mg Injection will be only given to patients who have enrolled in to TOUCH program.

Disease/Condition Glossary

Multiple sclerosis: Multiple sclerosis is a condition that affects the brain and spinal cord. The immune system attacks the protective covering of the nerves (myelin) and causes disrupted communication between the brain and body due to nerve damage. This causes symptoms such as problems with sensation, balance, vision, pain, impaired coordination, and fatigue.

Crohn’s disease: Crohn’s disease is a type of chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract, from mouth to anus. But mostly occurs in the small intestine and large intestine. The symptoms include blood in stools, stomach cramps, tiredness, diarrhoea, fever, weight loss, or loss of appetite.