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  3. Valkem 500 Oral Solution 100 ml

Valkem 500 Oral Solution 100 ml, Pack of 1 SOLUTION
Valkem 500 Oral Solution 100 ml, Pack of 1 SOLUTION
Valkem 500 Oral Solution 100 ml, Pack of 1 SOLUTION
Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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Composition :

DIVALPROEX-500MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Valkem 500 Oral Solution

Valkem 500 Oral Solution belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Valkem 500 Oral Solution is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Valkem 500 Oral Solution contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Valkem 500 Oral Solution increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder. 

Take Valkem 500 Oral Solution with or without food. Depending on your medical condition, you are advised to take Valkem 500 Oral Solution for as long as your doctor has prescribed it for you. In some cases, you may experience certain common side-effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Valkem 500 Oral Solution without consulting your doctor to avoid worsening seizures. Do not take Valkem 500 Oral Solution if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Valkem 500 Oral Solution . Consult your doctor before taking Valkem 500 Oral Solution if you are breastfeeding. Avoid driving or operating machinery as Valkem 500 Oral Solution causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Valkem 500 Oral Solution as it could lead to increased dizziness. Care should be taken while giving Valkem 500 Oral Solution to children below two years as there is a higher risk of liver intoxication during the first 6months of treatment. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Valkem 500 Oral Solution

Epilepsy, bipolar disorder, migraine

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush it.Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.Sprinkle capsule: Swallow it as a whole with water or sprinkle the capsule contents on food and consume.

Medicinal Benefits

Valkem 500 Oral Solution belongs to a group of medicines called anticonvulsants or anti-epileptics. Valkem 500 Oral Solution is used to treat epilepsy/seizures/fits. Also, Valkem 500 Oral Solution is used to treat mood disorders and prevent migraine headaches. Valkem 500 Oral Solution decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures. Valkem 500 Oral Solution treats mood disorders by increasing the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Valkem 500 Oral Solution prevents migraine headaches by limiting the transmission of nerve pain. Valkem 500 Oral Solution is used alone or in combination to treat simple, complex partial, and complex absence seizures. Valkem 500 Oral Solution is used in combination to treat multiple seizures, such as absence seizures.

Storage

Store in a cool and dry place away from sunlight
Side effects of Valkem 500 Oral Solution 100 ml
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Drug Warnings

Do not take Valkem 500 Oral Solution if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders. Inform your doctor before taking Valkem 500 Oral Solution if you have pancreatitis, blood problems or multi-organ hypersensitivity. Consult your doctor immediately if you experience suicidal tendencies while taking Valkem 500 Oral Solution . Valkem 500 Oral Solution may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems. Please do not stop taking Valkem 500 Oral Solution without consulting your doctor to avoid worsening of seizures. Do not take Valkem 500 Oral Solution if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Valkem 500 Oral Solution . Consult your doctor before taking Valkem 500 Oral Solution if you are breastfeeding. Avoid driving or operating machinery as Valkem 500 Oral Solution causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Valkem 500 Oral Solution as it could lead to increased dizziness. Care should be taken while giving Valkem 500 Oral Solution to children below 2 years as there is a higher risk of liver intoxication during the first six months of treatment.

Drug-Drug Interactions

verifiedApollotooltip
DivalproexGlycerol phenylbutyrate
Critical
DivalproexKetamine
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Glycerol phenylbutyrate and Valkem 500 Oral Solution 100 ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Valkem 500 Oral Solution 100 ml together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexKetamine
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and Ketamine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml and Ketamine can lead to an interaction, it can be taken if advised by your doctor. If you have any symptoms such as dizziness, drowsiness, shortness of breath, or impairment in thinking and motor coordination, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
DivalproexEsketamine
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Esketamine and Valkem 500 Oral Solution 100 ml can increase the side effects of esketamine.

How to manage the interaction:
Although taking Valkem 500 Oral Solution 100 ml and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexKetoconazole
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Ketoconazole and Valkem 500 Oral Solution 100 ml may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Valkem 500 Oral Solution 100 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexLeflunomide
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Valkem 500 Oral Solution 100 ml and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DivalproexSodium oxybate
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Sodium oxybate and Valkem 500 Oral Solution 100 ml can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Valkem 500 Oral Solution 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Sodium phenylbutyrate and Valkem 500 Oral Solution 100 ml can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
DivalproexBuprenorphine
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of buprenorphine with Valkem 500 Oral Solution 100 ml may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Valkem 500 Oral Solution 100 ml can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexBexarotene
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexTeriflunomide
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.
  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.
  • Have a seizure response plan, help those around you know what to do.
  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Valkem 500 Oral Solution decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.

Valkem 500 Oral Solution helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect.

Valkem 500 Oral Solution limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.

Valkem 500 Oral Solution may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Valkem 500 Oral Solution only after consulting a doctor.

Valkem 500 Oral Solution may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.

Do not discontinue Valkem 500 Oral Solution without consulting your doctor. To treat your condition effectually, continue taking Valkem 500 Oral Solution for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Valkem 500 Oral Solution ; your doctor will gradually reduce the dose to avoid worsening seizures.

Valkem 500 Oral Solution may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Valkem 500 Oral Solution may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Valkem 500 Oral Solution .

Topiramate (anticonvulsant) should not be taken along with Valkem 500 Oral Solution as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PREGABALIN
  • TOPIRAMATE
  • PHENOBARBITAL
  • PRIMIDONE
  • PHENYTOIN
  • CARBAMAZEPINE
  • LAMOTRIGINE
  • FELBAMATE
  • ETHOSUXIMIDE
  • ZIDOVUDINE
  • DULOXETINE
  • ESCITALOPRAM
  • AMITRIPTYLINE
  • NORTRIPTYLINE
  • ARIPIPRAZOLE
  • LURASIDONE
  • QUETIAPINE
  • ALPRAZOLAM
  • RIFAMPICIN
  • WARFARIN
  • IMIPENEM
  • MEROPENEM
  • DIAZEPAM

Special Advise

  • Regular monitoring of blood count and coagulation tests are advised while taking Valkem 500 Oral Solution as it may cause thrombocytopenia (low platelet levels).
  • Valkem 500 Oral Solution may cause liver toxicity, usually during the first 6months of treatment. Children below two years are at a higher risk. Regular monitoring of liver function tests before treatment and at frequent intervals is advised.
  • Valkem 500 Oral Solution might alter thyroid function tests and urine ketone tests. Inform the person doing the tests that you are taking Valkem 500 Oral Solution .

Disease/Condition Glossary

Epilepsy: Epilepsy is a sudden rush of electricity in the brain. It is a disorder of the nervous system which occurs due to disturbed nerve cell activity in the brain. In epilepsy the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulse that affect an individual's consciousness, movements or sensations. Seizures are of two types: generalised and partial seizures. Generalised seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle twitches and spasms. Stronger seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury or stroke.

Mood disorder: It is a mental health disorder which mainly affects a person's emotional state. A mood disorder is associated with episodes of mood swings ranging from manic highs to depressive lows.

Migraine: Migraine is a neurological condition which is characterized by intense headaches. Symptoms include nausea, vomiting, and sensitivity to light and sound.

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