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  3. Valparin Oral Solution 100 ml

Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
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Valparin Oral Solution 100 ml, Pack of 1 Oral Solution
Valparin Oral Solution 100 ml, Pack of 1 Oral Solution
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Whats That

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Composition :

SODIUM VALPROATE-200MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

NPPA :

Regulated

About Valparin Oral Solution

Valparin Oral Solution belongs to the group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Valparin Oral Solution is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state. 
­ 
Valparin Oral Solution contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Valparin Oral Solution increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 
 
You can take Valparin Oral Solution with or without food. You are advised to take Valparin Oral Solution for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Please do not stop taking Valparin Oral Solution without consulting your doctor to avoid worsening of seizures. Contact your doctor if your child gets her first-period whilst on treatment with Valparin Oral Solution . Do not take Valparin Oral Solution if you are pregnant as it could cause serious congenital disabilities. If you are of child-bearing age, use effective contraception while taking Valparin Oral Solution . Consult your doctor before taking Valparin Oral Solution if you are breastfeeding. Do not drive or operate machinery as Valparin Oral Solution may cause drowsiness and dizziness. Avoid consuming alcohol along with Valparin Oral Solution as it could lead to increased dizziness and sleepiness.

Uses of Valparin Oral Solution

Epilepsy, Bipolar disorder, Migraine

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not chew, or break the tablet/capsule. Syrup/Suspension/Drops: Take the prescribed dose/quantity by mouth using the measuring cup/dosing syringe; shake the pack well before each use.

Key Benefits

Valparin Oral Solution belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). Additionally, Valparin Oral Solution is also used to treat bipolar disorder and prevent migraine headaches. Valparin Oral Solution decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Valparin Oral Solution is used to treat both localized (seizures which affect only a part of the brain) and generalized seizures (seizures which affect the entire brain).

Storage

Store in a cool and dry place away from sunlight
Side effects of Valparin Oral Solution 100 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Consume controlled amounts of salt to raise sodium levels.
  • Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
  • Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
  • Choose frozen vegetables without added butter or sauce.
  • Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
  • Avoid excessive salt intake, but allow for controlled increases as needed.
  • Monitor and manage underlying health conditions that may contribute to hyponatremia.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Brush and floss regularly twice a day with fluoride toothpaste and once a day with floss.
  • Use a soft or extra-soft toothbrush.
  • Avoid tobacco products, as smoking can worsen gum problems.
  • Use an antimicrobial mouthwash to reduce bacteria and prevent bleeding.
  • Drink green tea rich in catechin to reduce inflammation from oral bacteria.
  • Eat a balanced diet high in nutrients and low in sugar.
  • Reduce stress to minimize inflammation and gum bleeding.
  • Consult your dentist if gums bleed consistently.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.

Drug Warnings

Do not take Valparin Oral Solution if you are allergic to any of its contents; if you have liver problems, porphyria, urine-related problems (like urea cycle disorder), diabetes, immune system disorder or kidney problems. Consult your doctor immediately if you experience suicidal tendencies while taking Valparin Oral Solution . Contact your doctor if your child gets her first period during the treatment with Valparin Oral Solution . Do not take Valparin Oral Solution if you are pregnant unless prescribed by the doctor as it is pregnancy category C medicine and can cause serious congenital disabilities. Consult your doctor before taking Valparin Oral Solution if you are breastfeeding. Valparin Oral Solution may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Valparin Oral Solution as it could lead to increased dizziness and sleepiness. 

Drug-Drug Interactions

verifiedApollotooltip
Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateTeriflunomide
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Valparin Oral Solution 100 ml:
Combining Sodium phenylbutyrate and Valparin Oral Solution 100 ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Valparin Oral Solution 100 ml is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Teriflunomide and Valparin Oral Solution 100 ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Valparin Oral Solution 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Lithium with Valparin Oral Solution 100 ml can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Valparin Oral Solution 100 ml can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Valparin Oral Solution 100 ml with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Valparin Oral Solution 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Leflunomide and Valparin Oral Solution 100 ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Valparin Oral Solution 100 ml can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
The combined use of Ertapenem and Valparin Oral Solution 100 ml can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Valparin Oral Solution 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Ketamine and Valparin Oral Solution 100 ml can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Valparin Oral Solution 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Meropenam and Valparin Oral Solution 100 ml together can reduce the effect of Valparin Oral Solution 100 ml.

How to manage the interaction:
Co-administration of Meropenam and Valparin Oral Solution 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Co-administration of Vorinostat with Valparin Oral Solution 100 ml can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Valparin Oral Solution 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Valparin Oral Solution 100 ml:
Using buprenorphine together with Valparin Oral Solution 100 ml may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Valparin Oral Solution 100 ml can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well; get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
  • Have a seizure response plan that helps those around you know what to do.
  • Prepare your living area; small changes may help in reducing the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Side Effects of Valparin Oral Solution

  • Stomach pain
  • Nausea
  • Vomiting
  • Dry mouth
  • Tremors
  • Tiredness
  • Sleepiness
  • Headache
  • Weight gain
  • Hair loss

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:32 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Valparin Oral Solution decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizures episodes.

Valparin Oral Solution helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.

Valparin Oral Solution limits the transmission of nerve pain, thereby prevents migraine headache. Migraine is a neurological condition which is characterized by intense headaches.

Do not discontinue Valparin Oral Solution without consulting your doctor. To treat your condition effectually, continue taking Valparin Oral Solution for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Valparin Oral Solution ; your doctor will reduce the dose gradually to avoid worsening of seizures.

Birth-control pills like oestrogen-containing products may affect the way Valparin Oral Solution works. It is better to consult the doctor if you are using birth control pills to avoid pregnancy.

Valparin Oral Solution may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.

Valparin Oral Solution might cause fertility issues in both men and women. However, it can be reversible upon discontinuation of Valparin Oral Solution . In rare cases, Valparin Oral Solution can be a contributing factor in male infertility.

Limit caffeine intake, avoid smoking and mouthwashes containing alcohol, drink water regularly, and chew sugar-free gum/candy might prevent dry mouth.

Valparin Oral Solution may change the results of liver enzymes, and urine and blood tests. Inform the person doing the tests that you are taking Valparin Oral Solution .

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PHENOBARBITAL
  • PHENYTOIN
  • PRIMIDONE
  • CARBAMAZEPINE
  • TOPIRAMATE
  • ACETAZOLAMIDE
  • LAMOTRIGINE
  • FELBAMATE
  • WARFARIN
  • ZIDOVUDINE
  • LOPINAVIR
  • RITONAVIR
  • MOCLOBEMIDE
  • SELEGILINE
  • LINEZOLID
  • AMITRIPTYLINE
  • SERTRALINE
  • QUETIAPINE
  • OLANZAPINE
  • RISPERIDONE
  • NIMODIPINE
  • PROPOFOL
  • ESTROGEN
  • LEVONORGESTREL
  • MEFLOQUINE
  • CHLOROQUINE
  • CIMETIDINE
  • IMIPENEM
  • MEROPENEM
  • RIFAMPICIN
  • ERYTHROMYCIN
  • CLONAZEPAM
  • DIAZEPAM
  • CHOLESTYRAMINE

Special Advise

  • Contact your doctor if your child gets her first-period whilst on treatment with Valparin Oral Solution .
  • Valparin Oral Solution might affect blood and urine tests. Inform the person doing the tests that you are taking Valparin Oral Solution .
  • If you are of child-bearing age, use effective contraception without interruptions during your entire treatment with Valparin Oral Solution .
  • Consult your doctor immediately if you become pregnant while taking Valparin Oral Solution .

Disease/Condition Glossary

Epilepsy: Epilepsy is a sudden rush of electricity in the brain. It is a disorder of the nervous system which occurs due to disturbed nerve cell activity in the brain. In epilepsy the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulses that affect an individual's consciousness, movements or sensations. Seizures are of two types: generalized and partial seizures. Generalized seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle twitches and spasms. Stronger seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury or stroke.

Bipolar disorder: Bipolar disorder, also known as manic depression or bipolar disease, is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows. 

Have a query?

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Alcohol

Safe if prescribed

Avoid consumption of alcohol while taking Valparin Oral Solution as it may cause increased dizziness and sleepiness.

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Pregnancy

Consult your doctor

Valparin Oral Solution belongs to pregnancy category D. Avoid taking Valparin Oral Solution if you are pregnant as it could lead to serious birth defects.

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Breast Feeding

Consult your doctor

Valparin Oral Solution may pass into breastmilk. Consult your doctor before taking Valparin Oral Solution if you are breastfeeding.

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Driving

Safe if prescribed

Valparin Oral Solution causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Consult your doctor

Valparin Oral Solution should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Valparin Oral Solution can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

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