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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS

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ORAL

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About Valproval 500 CR Tablet

Valproval 500 CR Tablet belongs to the group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Valproval 500 CR Tablet is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state. 
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Valproval 500 CR Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Valproval 500 CR Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 
 
You can take Valproval 500 CR Tablet with or without food. You are advised to take Valproval 500 CR Tablet for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Please do not stop taking Valproval 500 CR Tablet without consulting your doctor to avoid worsening of seizures. Contact your doctor if your child gets her first-period whilst on treatment with Valproval 500 CR Tablet . Do not take Valproval 500 CR Tablet if you are pregnant as it could cause serious congenital disabilities. If you are of child-bearing age, use effective contraception while taking Valproval 500 CR Tablet . Consult your doctor before taking Valproval 500 CR Tablet if you are breastfeeding. Do not drive or operate machinery as Valproval 500 CR Tablet may cause drowsiness and dizziness. Avoid consuming alcohol along with Valproval 500 CR Tablet as it could lead to increased dizziness and sleepiness.

Uses of Valproval 500 CR Tablet

Epilepsy, Bipolar disorder, Migraine

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not chew, or break the tablet/capsule. Syrup/Suspension/Drops: Take the prescribed dose/quantity by mouth using the measuring cup/dosing syringe; shake the pack well before each use.

Medicinal Benefits

Valproval 500 CR Tablet belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). Additionally, Valproval 500 CR Tablet is also used to treat bipolar disorder and prevent migraine headaches. Valproval 500 CR Tablet decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Valproval 500 CR Tablet is used to treat both localized (seizures which affect only a part of the brain) and generalized seizures (seizures which affect the entire brain).

Storage

Keep Valproval 500 CR Tablet out of reach and sight of children.

Drug Warnings

Do not take Valproval 500 CR Tablet if you are allergic to any of its contents; if you have liver problems, porphyria, urine-related problems (like urea cycle disorder), diabetes, immune system disorder or kidney problems. Consult your doctor immediately if you experience suicidal tendencies while taking Valproval 500 CR Tablet . Contact your doctor if your child gets her first period during the treatment with Valproval 500 CR Tablet . Do not take Valproval 500 CR Tablet if you are pregnant unless prescribed by the doctor as it is pregnancy category C medicine and can cause serious congenital disabilities. Consult your doctor before taking Valproval 500 CR Tablet if you are breastfeeding. Valproval 500 CR Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Valproval 500 CR Tablet as it could lead to increased dizziness and sleepiness. 

Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well; get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
  • Have a seizure response plan that helps those around you know what to do.
  • Prepare your living area; small changes may help in reducing the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Author Details

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FAQs

Valproval 500 CR Tablet decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizures episodes.

Valproval 500 CR Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.

Valproval 500 CR Tablet limits the transmission of nerve pain, thereby prevents migraine headache. Migraine is a neurological condition which is characterized by intense headaches.

Do not discontinue Valproval 500 CR Tablet without consulting your doctor. To treat your condition effectually, continue taking Valproval 500 CR Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Valproval 500 CR Tablet ; your doctor will reduce the dose gradually to avoid worsening of seizures.

Birth-control pills like oestrogen-containing products may affect the way Valproval 500 CR Tablet works. It is better to consult the doctor if you are using birth control pills to avoid pregnancy.

Valproval 500 CR Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.

Valproval 500 CR Tablet might cause fertility issues in both men and women. However, it can be reversible upon discontinuation of Valproval 500 CR Tablet . In rare cases, Valproval 500 CR Tablet can be a contributing factor in male infertility.

Limit caffeine intake, avoid smoking and mouthwashes containing alcohol, drink water regularly, and chew sugar-free gum/candy might prevent dry mouth.

Valproval 500 CR Tablet may change the results of liver enzymes, and urine and blood tests. Inform the person doing the tests that you are taking Valproval 500 CR Tablet .

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PHENOBARBITAL
  • PHENYTOIN
  • PRIMIDONE
  • CARBAMAZEPINE
  • TOPIRAMATE
  • ACETAZOLAMIDE
  • LAMOTRIGINE
  • FELBAMATE
  • WARFARIN
  • ZIDOVUDINE
  • LOPINAVIR
  • RITONAVIR
  • MOCLOBEMIDE
  • SELEGILINE
  • LINEZOLID
  • AMITRIPTYLINE
  • SERTRALINE
  • QUETIAPINE
  • OLANZAPINE
  • RISPERIDONE
  • NIMODIPINE
  • PROPOFOL
  • ESTROGEN
  • LEVONORGESTREL
  • MEFLOQUINE
  • CHLOROQUINE
  • CIMETIDINE
  • IMIPENEM
  • MEROPENEM
  • RIFAMPICIN
  • ERYTHROMYCIN
  • CLONAZEPAM
  • DIAZEPAM
  • CHOLESTYRAMINE

Special Advise

  • Contact your doctor if your child gets her first-period whilst on treatment with Valproval 500 CR Tablet .
  • Valproval 500 CR Tablet might affect blood and urine tests. Inform the person doing the tests that you are taking Valproval 500 CR Tablet .
  • If you are of child-bearing age, use effective contraception without interruptions during your entire treatment with Valproval 500 CR Tablet .
  • Consult your doctor immediately if you become pregnant while taking Valproval 500 CR Tablet .

Disease/Condition Glossary

Epilepsy: Epilepsy is a sudden rush of electricity in the brain. It is a disorder of the nervous system which occurs due to disturbed nerve cell activity in the brain. In epilepsy the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden bursts of electrical impulses that affect an individual's consciousness, movements or sensations. Seizures are of two types: generalized and partial seizures. Generalized seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle twitches and spasms. Stronger seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury or stroke.

Bipolar disorder: Bipolar disorder, also known as manic depression or bipolar disease, is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows. 

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